Association between cytokine concentration kinetics and prolonged fever in febrile neutropenic children with bacteremia
Introduction: Although prolonged fever in patients with neutropenic fever (NF) during empirical antibiotic therapy could be caused by dysregulated immune responses, its association with cytokine concentrations has rarely been investigated. This study determined the kinetics of cytokine concentration...
Gespeichert in:
| Veröffentlicht in: | International journal of immunopathology and pharmacology 2022, Vol.36, p.3946320221095015-3946320221095015 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3946320221095015 |
|---|---|
| container_issue | |
| container_start_page | 3946320221095015 |
| container_title | International journal of immunopathology and pharmacology |
| container_volume | 36 |
| creator | Kim, Seong Koo Han, Seung Beom Kang, Jin Han |
| description | Introduction: Although prolonged fever in patients with neutropenic fever (NF) during empirical antibiotic therapy could be caused by dysregulated immune responses, its association with cytokine concentrations has rarely been investigated. This study determined the kinetics of cytokine concentrations in pediatric patients with NF and bacteremia and evaluated the impact of cytokine concentration kinetics on prolonged fever. Methods: Concentrations of 13 cytokines were measured on the initial day of NF (Day 1) and 3 days (Day 4) and 7 days (Day 8) later in 10 patients with NF with bacteremia, and their kinetics was determined. The results for each cytokine concentration on each sampling day were compared for patients with fever that lasted ⩾3 days and those with fever that lasted |
| doi_str_mv | 10.1177/03946320221095015 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9121457</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_03946320221095015</sage_id><sourcerecordid>2758071371</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3335-e3350006caea66e2a10dc7d0023dea8abb9cca196277d39b4e55d1e0885836a13</originalsourceid><addsrcrecordid>eNp1UU1r3DAUFKUlWdL8gFyKoJdenOrDkuxLIYS0CQRyac9Clt7uKvVKW0nOkn9fGafpF7lIQjNv3gyD0Bkl55Qq9ZHwvpWcEcYo6QWh4hVaMSK6RvGufY1WM97MhGN0mvM9IYQS3oqOHqFjLoQSrBcrdLjIOVpvio8BD1AOAAHbxxK_-wDYxmAhlLTA81fxNmMTHN6nOMawAYfX8AAJ-1AfQ_Ij4ABTSXEPwVtst350qWoefNniwdgCCXbevEVv1mbMcPp0n6Bvn6--Xl43t3dfbi4vbhvLORcN1KM6l9aAkRKYocRZ5Qhh3IHpzDD01hraS6aU4_3QghCOAuk60XFpKD9Bnxbd_TTswC1pRr1PfmfSo47G67-R4Ld6Ex90TxlthaoCH54EUvwxQS5657OFcTQB4pQ1k1JQyqTglfr-H-p9nFKo8TRToiOKcjU7ogvLpphzgvWzGUr03Kz-r9k68-7PFM8Tv3qshPOFkM0Gfq99WfEnoyOtyQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2758071371</pqid></control><display><type>article</type><title>Association between cytokine concentration kinetics and prolonged fever in febrile neutropenic children with bacteremia</title><source>Sage Journals GOLD Open Access 2024</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Kim, Seong Koo ; Han, Seung Beom ; Kang, Jin Han</creator><creatorcontrib>Kim, Seong Koo ; Han, Seung Beom ; Kang, Jin Han</creatorcontrib><description>Introduction: Although prolonged fever in patients with neutropenic fever (NF) during empirical antibiotic therapy could be caused by dysregulated immune responses, its association with cytokine concentrations has rarely been investigated. This study determined the kinetics of cytokine concentrations in pediatric patients with NF and bacteremia and evaluated the impact of cytokine concentration kinetics on prolonged fever. Methods: Concentrations of 13 cytokines were measured on the initial day of NF (Day 1) and 3 days (Day 4) and 7 days (Day 8) later in 10 patients with NF with bacteremia, and their kinetics was determined. The results for each cytokine concentration on each sampling day were compared for patients with fever that lasted ⩾3 days and those with fever that lasted <3 days. Results: Interleukin (IL)-6 (p < .001) and IL-10 (p = .001) concentrations were significantly higher on Day 1 than on Days 4 and 8. However, the increased IL-6 (p = 1.000) and IL-10 (p = 1.000) concentrations on Day 1 were not associated with prolonged fever (⩾3 days). For other cytokines, the concentrations measured on Days 1, 4, and 8 were similar regardless of fever duration. Conclusion: Prolonged fever in patients with NF and bacteremia was not associated with a prolonged increase in a specific cytokine concentration.</description><identifier>ISSN: 0394-6320</identifier><identifier>EISSN: 2058-7384</identifier><identifier>DOI: 10.1177/03946320221095015</identifier><identifier>PMID: 35575295</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Bacteremia ; Cytokines ; Fever ; Immune response ; Interleukin 10 ; Interleukin 6 ; Letter to the Editor ; Neutropenia ; Pediatrics</subject><ispartof>International journal of immunopathology and pharmacology, 2022, Vol.36, p.3946320221095015-3946320221095015</ispartof><rights>The Author(s) 2022</rights><rights>The Author(s) 2022. This work is licensed under the Creative Commons Attribution – Non-Commercial License https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2022 2022 SAGE Publications Ltd unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3335-e3350006caea66e2a10dc7d0023dea8abb9cca196277d39b4e55d1e0885836a13</cites><orcidid>0000-0002-1299-2137</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121457/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121457/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,21966,27853,27923,27924,27925,44945,45333,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35575295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Seong Koo</creatorcontrib><creatorcontrib>Han, Seung Beom</creatorcontrib><creatorcontrib>Kang, Jin Han</creatorcontrib><title>Association between cytokine concentration kinetics and prolonged fever in febrile neutropenic children with bacteremia</title><title>International journal of immunopathology and pharmacology</title><addtitle>Int J Immunopathol Pharmacol</addtitle><description>Introduction: Although prolonged fever in patients with neutropenic fever (NF) during empirical antibiotic therapy could be caused by dysregulated immune responses, its association with cytokine concentrations has rarely been investigated. This study determined the kinetics of cytokine concentrations in pediatric patients with NF and bacteremia and evaluated the impact of cytokine concentration kinetics on prolonged fever. Methods: Concentrations of 13 cytokines were measured on the initial day of NF (Day 1) and 3 days (Day 4) and 7 days (Day 8) later in 10 patients with NF with bacteremia, and their kinetics was determined. The results for each cytokine concentration on each sampling day were compared for patients with fever that lasted ⩾3 days and those with fever that lasted <3 days. Results: Interleukin (IL)-6 (p < .001) and IL-10 (p = .001) concentrations were significantly higher on Day 1 than on Days 4 and 8. However, the increased IL-6 (p = 1.000) and IL-10 (p = 1.000) concentrations on Day 1 were not associated with prolonged fever (⩾3 days). For other cytokines, the concentrations measured on Days 1, 4, and 8 were similar regardless of fever duration. Conclusion: Prolonged fever in patients with NF and bacteremia was not associated with a prolonged increase in a specific cytokine concentration.</description><subject>Bacteremia</subject><subject>Cytokines</subject><subject>Fever</subject><subject>Immune response</subject><subject>Interleukin 10</subject><subject>Interleukin 6</subject><subject>Letter to the Editor</subject><subject>Neutropenia</subject><subject>Pediatrics</subject><issn>0394-6320</issn><issn>2058-7384</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1UU1r3DAUFKUlWdL8gFyKoJdenOrDkuxLIYS0CQRyac9Clt7uKvVKW0nOkn9fGafpF7lIQjNv3gyD0Bkl55Qq9ZHwvpWcEcYo6QWh4hVaMSK6RvGufY1WM97MhGN0mvM9IYQS3oqOHqFjLoQSrBcrdLjIOVpvio8BD1AOAAHbxxK_-wDYxmAhlLTA81fxNmMTHN6nOMawAYfX8AAJ-1AfQ_Ij4ABTSXEPwVtst350qWoefNniwdgCCXbevEVv1mbMcPp0n6Bvn6--Xl43t3dfbi4vbhvLORcN1KM6l9aAkRKYocRZ5Qhh3IHpzDD01hraS6aU4_3QghCOAuk60XFpKD9Bnxbd_TTswC1pRr1PfmfSo47G67-R4Ld6Ex90TxlthaoCH54EUvwxQS5657OFcTQB4pQ1k1JQyqTglfr-H-p9nFKo8TRToiOKcjU7ogvLpphzgvWzGUr03Kz-r9k68-7PFM8Tv3qshPOFkM0Gfq99WfEnoyOtyQ</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Kim, Seong Koo</creator><creator>Han, Seung Beom</creator><creator>Kang, Jin Han</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>AFRWT</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1299-2137</orcidid></search><sort><creationdate>2022</creationdate><title>Association between cytokine concentration kinetics and prolonged fever in febrile neutropenic children with bacteremia</title><author>Kim, Seong Koo ; Han, Seung Beom ; Kang, Jin Han</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3335-e3350006caea66e2a10dc7d0023dea8abb9cca196277d39b4e55d1e0885836a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Bacteremia</topic><topic>Cytokines</topic><topic>Fever</topic><topic>Immune response</topic><topic>Interleukin 10</topic><topic>Interleukin 6</topic><topic>Letter to the Editor</topic><topic>Neutropenia</topic><topic>Pediatrics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Seong Koo</creatorcontrib><creatorcontrib>Han, Seung Beom</creatorcontrib><creatorcontrib>Kang, Jin Han</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of immunopathology and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Seong Koo</au><au>Han, Seung Beom</au><au>Kang, Jin Han</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between cytokine concentration kinetics and prolonged fever in febrile neutropenic children with bacteremia</atitle><jtitle>International journal of immunopathology and pharmacology</jtitle><addtitle>Int J Immunopathol Pharmacol</addtitle><date>2022</date><risdate>2022</risdate><volume>36</volume><spage>3946320221095015</spage><epage>3946320221095015</epage><pages>3946320221095015-3946320221095015</pages><issn>0394-6320</issn><eissn>2058-7384</eissn><abstract>Introduction: Although prolonged fever in patients with neutropenic fever (NF) during empirical antibiotic therapy could be caused by dysregulated immune responses, its association with cytokine concentrations has rarely been investigated. This study determined the kinetics of cytokine concentrations in pediatric patients with NF and bacteremia and evaluated the impact of cytokine concentration kinetics on prolonged fever. Methods: Concentrations of 13 cytokines were measured on the initial day of NF (Day 1) and 3 days (Day 4) and 7 days (Day 8) later in 10 patients with NF with bacteremia, and their kinetics was determined. The results for each cytokine concentration on each sampling day were compared for patients with fever that lasted ⩾3 days and those with fever that lasted <3 days. Results: Interleukin (IL)-6 (p < .001) and IL-10 (p = .001) concentrations were significantly higher on Day 1 than on Days 4 and 8. However, the increased IL-6 (p = 1.000) and IL-10 (p = 1.000) concentrations on Day 1 were not associated with prolonged fever (⩾3 days). For other cytokines, the concentrations measured on Days 1, 4, and 8 were similar regardless of fever duration. Conclusion: Prolonged fever in patients with NF and bacteremia was not associated with a prolonged increase in a specific cytokine concentration.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>35575295</pmid><doi>10.1177/03946320221095015</doi><orcidid>https://orcid.org/0000-0002-1299-2137</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0394-6320 |
| ispartof | International journal of immunopathology and pharmacology, 2022, Vol.36, p.3946320221095015-3946320221095015 |
| issn | 0394-6320 2058-7384 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9121457 |
| source | Sage Journals GOLD Open Access 2024; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Bacteremia Cytokines Fever Immune response Interleukin 10 Interleukin 6 Letter to the Editor Neutropenia Pediatrics |
| title | Association between cytokine concentration kinetics and prolonged fever in febrile neutropenic children with bacteremia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T15%3A49%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20cytokine%20concentration%20kinetics%20and%20prolonged%20fever%20in%20febrile%20neutropenic%20children%20with%20bacteremia&rft.jtitle=International%20journal%20of%20immunopathology%20and%20pharmacology&rft.au=Kim,%20Seong%20Koo&rft.date=2022&rft.volume=36&rft.spage=3946320221095015&rft.epage=3946320221095015&rft.pages=3946320221095015-3946320221095015&rft.issn=0394-6320&rft.eissn=2058-7384&rft_id=info:doi/10.1177/03946320221095015&rft_dat=%3Cproquest_pubme%3E2758071371%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2758071371&rft_id=info:pmid/35575295&rft_sage_id=10.1177_03946320221095015&rfr_iscdi=true |