Neuroprotective Effect of Carnosine Is Mediated by Insulin-Degrading Enzyme

Neuroprotective Effect of Carnosine Is Mediated by Insulin-Degrading Enzyme

l-Carnosine is an endogenous dipeptide that has high potential for therapeutic purposes, being an antioxidant with metal chelating, anti-aggregating, anti-inflammatory, and neuroprotective properties. Despite its potential therapeutic values, the biomolecular mechanisms involved in neuroprotection a...

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Veröffentlicht in:ACS chemical neuroscience 2022-05, Vol.13 (10), p.1588-1593
Hauptverfasser: Distefano, Alessia, Caruso, Giuseppe, Oliveri, Valentina, Bellia, Francesco, Sbardella, Diego, Zingale, Gabriele Antonio, Caraci, Filippo, Grasso, Giuseppe
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container_end_page 1593
container_issue 10
container_start_page 1588
container_title ACS chemical neuroscience
container_volume 13
creator Distefano, Alessia
Caruso, Giuseppe
Oliveri, Valentina
Bellia, Francesco
Sbardella, Diego
Zingale, Gabriele Antonio
Caraci, Filippo
Grasso, Giuseppe
description l-Carnosine is an endogenous dipeptide that has high potential for therapeutic purposes, being an antioxidant with metal chelating, anti-aggregating, anti-inflammatory, and neuroprotective properties. Despite its potential therapeutic values, the biomolecular mechanisms involved in neuroprotection are not fully understood. Here, we demonstrate, at chemical and biochemical levels, that insulin-degrading enzyme plays a pivotal role in carnosine neuroprotection.
doi_str_mv 10.1021/acschemneuro.2c00201
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title Neuroprotective Effect of Carnosine Is Mediated by Insulin-Degrading Enzyme
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