'Channeling' therapeutic discovery for epileptic encephalopathy through iPSC technologies

Induced pluripotent stem cell (iPSC) and gene editing technologies have revolutionized the field of in vitro disease modeling, granting us access to disease-pertinent human cells of the central nervous system. These technologies are particularly well suited for the study of diseases with strong mono...

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Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 2022-05, Vol.43 (5), p.392-405
Hauptverfasser:	Simkin, Dina, Ambrosi, Christina, Marshall, Kelly A, Williams, Luis A, Eisenberg, Jordyn, Gharib, Mennat, Dempsey, Graham T, George, Jr, Alfred L, McManus, Owen B, Kiskinis, Evangelos
Format:	Artikel
Sprache:	eng
Schlagworte:	Channelopathies Child Epilepsy - genetics Epilepsy - therapy Humans Induced Pluripotent Stem Cells Mutation Neurons
Online-Zugang:	Volltext
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