ATP spreads inflammation to other limbs through crosstalk between sensory neurons and interneurons
Neural circuits between lesions are one mechanism through which local inflammation spreads to remote positions. Here, we show the inflammatory signal on one side of the joint is spread to the other side via sensory neuron-interneuron crosstalk, with ATP at the core. Surgical ablation or pharmacologi...
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| Veröffentlicht in: | The Journal of experimental medicine 2022-06, Vol.219 (6) |
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| creator | Hasebe, Rie Murakami, Kaoru Harada, Masaya Halaka, Nada Nakagawa, Hiroshi Kawano, Fuminori Ohira, Yoshinobu Kawamoto, Tadafumi Yull, Fiona E Blackwell, Timothy S Nio-Kobayashi, Junko Iwanaga, Toshihiko Watanabe, Masahiko Watanabe, Nobuhiro Hotta, Harumi Yamashita, Toshihide Kamimura, Daisuke Tanaka, Yuki Murakami, Masaaki |
| description | Neural circuits between lesions are one mechanism through which local inflammation spreads to remote positions. Here, we show the inflammatory signal on one side of the joint is spread to the other side via sensory neuron-interneuron crosstalk, with ATP at the core. Surgical ablation or pharmacological inhibition of this neural pathway prevented inflammation development on the other side. Mechanistic analysis showed that ATP serves as both a neurotransmitter and an inflammation enhancer, thus acting as an intermediary between the local inflammation and neural pathway that induces inflammation on the other side. These results suggest blockade of this neural pathway, which is named the remote inflammation gateway reflex, may have therapeutic value for inflammatory diseases, particularly those, such as rheumatoid arthritis, in which inflammation spreads to remote positions. |
| doi_str_mv | 10.1084/jem.20212019 |
| format | Article |
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Here, we show the inflammatory signal on one side of the joint is spread to the other side via sensory neuron-interneuron crosstalk, with ATP at the core. Surgical ablation or pharmacological inhibition of this neural pathway prevented inflammation development on the other side. Mechanistic analysis showed that ATP serves as both a neurotransmitter and an inflammation enhancer, thus acting as an intermediary between the local inflammation and neural pathway that induces inflammation on the other side. 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Here, we show the inflammatory signal on one side of the joint is spread to the other side via sensory neuron-interneuron crosstalk, with ATP at the core. Surgical ablation or pharmacological inhibition of this neural pathway prevented inflammation development on the other side. Mechanistic analysis showed that ATP serves as both a neurotransmitter and an inflammation enhancer, thus acting as an intermediary between the local inflammation and neural pathway that induces inflammation on the other side. 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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Brief Definitive Report Innate Immunity and Inflammation Neuroscience |
| title | ATP spreads inflammation to other limbs through crosstalk between sensory neurons and interneurons |
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