Intestinal microbiota composition of children with infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and multisystem inflammatory syndrome (MIS-C)
Microbiota composition may play a role in the development, prognosis, or post-infection of COVID-19. There are studies evaluating the microbiota composition at the time of diagnosis and during the course of COVID-19, especially in adults, while studies in children are limited and no study available...
Gespeichert in:
| Veröffentlicht in: | European journal of pediatrics 2022-08, Vol.181 (8), p.3175-3191 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3191 |
|---|---|
| container_issue | 8 |
| container_start_page | 3175 |
| container_title | European journal of pediatrics |
| container_volume | 181 |
| creator | Suskun, Cansu Kilic, Omer Yilmaz Ciftdogan, Dilek Guven, Sirin Karbuz, Adem Ozkaya Parlakay, Aslinur Kara, Yalcın Kacmaz, Ebru Sahin, Aslihan Boga, Aysun Kizmaz Isancli, Didem Gulhan, Belgin Kanik-Yuksek, Saliha Kiral, Eylem Bozan, Gurkan Arslanoglu, Mehmet Ozgür Kizil, Mahmut Can Dinleyici, Meltem Us, Tercan Varis, Ahmet Kaya, Mucahit Vandenplas, Yvan Dinleyici, Ener Cagri |
| description | Microbiota composition may play a role in the development, prognosis, or post-infection of COVID-19. There are studies evaluating the microbiota composition at the time of diagnosis and during the course of COVID-19, especially in adults, while studies in children are limited and no study available in children with multisystem inflammatory syndrome in children (MIS-C). This study was planned to compare intestinal microbiota composition in children diagnosed with MIS-C and acute COVID-19 infection with healthy children. In this prospective multicenter study, 25 children diagnosed with MIS-C, 20 with COVID-19 infection, and 19 healthy children were included. Intestinal microbiota composition was evaluated by 16 s rRNA gene sequencing. We observed changes of diversity, richness, and composition of intestinal microbiota in MIS-C cases compared to COVID-19 cases and in the healthy controls. The Shannon index was higher in the MIS-C group than the healthy controls (
p
|
| doi_str_mv | 10.1007/s00431-022-04494-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9117086</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2666906784</sourcerecordid><originalsourceid>FETCH-LOGICAL-c404t-d3d94aa93452ef318896186960281fda12e5703956aa30fb4ae066d676e7e15a3</originalsourceid><addsrcrecordid>eNp9ks1uEzEUhUcIREvhBVggS2zSxYD_xmNvkKoISqQiJApsLWfmTuNqbAfbkyrvxEPWSUopXbCyrfudc23fU1WvCX5HMG7fJ4w5IzWmtMacK16rJ9Ux4YzWBLfi6YP9UfUipWtcRIrI59URaxrZ0EYcV78XPkPK1psROdvFsLQhG9QFtw7JZhs8CgPqVnbsI3h0Y_MKWT9Aty_tjwk2EAGZbsqAIqS1jSaHuEVp6_sYHBS3GLzZ2DglRNHs8uzbZT0PP2t6iozvkZvGbNM2ZXA779E498hg9mVRFKcvq2eDGRO8ultPqh-fPn6ff64vvp4v5mcXdccxz3XPesWNUYw3FAZGpFSCSKEEppIMvSEUmhYz1QhjGB6W3AAWohetgBZIY9hJ9eHgu56WDvoOfI5m1OtonYlbHYzV_1a8XemrsNGKkBZLUQxmdwYx_JrK_2pnUwfjaDyEKWkqhFBYtJIX9O0j9DpMsYxjRynJWENlWyh6oMqEUoow3F-GYL0Lgz6EQZcw6H0YtCqiNw-fcS_5M_0CsAOQSslfQfzb-z-2t-2pwuw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2698335287</pqid></control><display><type>article</type><title>Intestinal microbiota composition of children with infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and multisystem inflammatory syndrome (MIS-C)</title><source>SpringerLink_现刊</source><creator>Suskun, Cansu ; Kilic, Omer ; Yilmaz Ciftdogan, Dilek ; Guven, Sirin ; Karbuz, Adem ; Ozkaya Parlakay, Aslinur ; Kara, Yalcın ; Kacmaz, Ebru ; Sahin, Aslihan ; Boga, Aysun ; Kizmaz Isancli, Didem ; Gulhan, Belgin ; Kanik-Yuksek, Saliha ; Kiral, Eylem ; Bozan, Gurkan ; Arslanoglu, Mehmet Ozgür ; Kizil, Mahmut Can ; Dinleyici, Meltem ; Us, Tercan ; Varis, Ahmet ; Kaya, Mucahit ; Vandenplas, Yvan ; Dinleyici, Ener Cagri</creator><creatorcontrib>Suskun, Cansu ; Kilic, Omer ; Yilmaz Ciftdogan, Dilek ; Guven, Sirin ; Karbuz, Adem ; Ozkaya Parlakay, Aslinur ; Kara, Yalcın ; Kacmaz, Ebru ; Sahin, Aslihan ; Boga, Aysun ; Kizmaz Isancli, Didem ; Gulhan, Belgin ; Kanik-Yuksek, Saliha ; Kiral, Eylem ; Bozan, Gurkan ; Arslanoglu, Mehmet Ozgür ; Kizil, Mahmut Can ; Dinleyici, Meltem ; Us, Tercan ; Varis, Ahmet ; Kaya, Mucahit ; Vandenplas, Yvan ; Dinleyici, Ener Cagri</creatorcontrib><description>Microbiota composition may play a role in the development, prognosis, or post-infection of COVID-19. There are studies evaluating the microbiota composition at the time of diagnosis and during the course of COVID-19, especially in adults, while studies in children are limited and no study available in children with multisystem inflammatory syndrome in children (MIS-C). This study was planned to compare intestinal microbiota composition in children diagnosed with MIS-C and acute COVID-19 infection with healthy children. In this prospective multicenter study, 25 children diagnosed with MIS-C, 20 with COVID-19 infection, and 19 healthy children were included. Intestinal microbiota composition was evaluated by 16 s rRNA gene sequencing. We observed changes of diversity, richness, and composition of intestinal microbiota in MIS-C cases compared to COVID-19 cases and in the healthy controls. The Shannon index was higher in the MIS-C group than the healthy controls (
p
< 0.01). At phylum level, in the MIS-C group, a significantly higher relative abundance of Bacteroidetes and lower abundance of Firmicutes was found compared to the control group. Intestinal microbiota composition changed in MIS-C cases compared to COVID-19 and healthy controls, and
Faecalibacterium prausnitzii
decreased;
Bacteroides uniformis
,
Bacteroides plebeius
,
Clostridium ramosum
,
Eubacterium dolichum
,
Eggerthella lenta
,
Bacillus thermoamylovorans
,
Prevotella tannerae
, and
Bacteroides coprophilus
were dominant in children with MIS-C. At species level, we observed decreased
Faecalibacterium prausnitzii
,
and
increased
Eubacterium dolichum
,
Eggerthella lenta
, and
Bacillus thermoamylovorans in children
with MIS-C and increased
Bifidobacterium adolescentis
and
Dorea formicigenerasus
in the COVID-19 group. Our study is the first to evaluate the microbiota composition in MIS-C cases. There is a substantial change in the composition of the gut microbiota: (1) reduction of
F. prausnitzii
in children with MIS-C and COVID-19; (2) an increase of
Eggerthella lenta
which is related with autoimmunity; and (3) the predominance of
E. dolichum
is associated with metabolic dysfunctions and obesity in children with MIS-C.
Conclusions
: Alterations of the intestinal microbiota might be part of pathogenesis of predisposing factor for MIS-C. It would be beneficial to conduct more extensive studies on the cause-effect relationship of these changes in microbiota composition and their effects on long-term prognosis.
What is Known:
• Microbiota composition may play a role in the development, prognosis, or post-infection of COVID-19.
•
However, the number of studies on children is limited, and no study on multisystem inflammatory syndrome in children is currently available (MIS-C).
What is New:
• In individuals with MIS-C, the composition of the gut microbiota changed dramatically.
• Decreased Faecalibacterium prausnitzii have been observed, increased Eggerthella lenta, which was previously linked to autoimmunity, and predominance of Eubacterium dolichum which was linked to metabolic dysfunction and obesity.
Graphical abstract</description><identifier>ISSN: 1432-1076</identifier><identifier>ISSN: 0340-6199</identifier><identifier>EISSN: 1432-1076</identifier><identifier>DOI: 10.1007/s00431-022-04494-9</identifier><identifier>PMID: 35585256</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Autoimmunity ; Bacillus thermoamylovorans ; Bacteroides ; Children ; Coronaviruses ; COVID-19 ; Digestive system ; Eggerthella lenta ; Eubacterium ; Faecalibacterium prausnitzii ; Gastrointestinal tract ; Infections ; Inflammation ; Intestinal microflora ; Intestine ; Medicine ; Medicine & Public Health ; Metabolism ; Microbiota ; Multisystem inflammatory syndrome in children ; Obesity ; Original ; Original Article ; Pediatrics ; Prognosis ; rRNA ; Severe acute respiratory syndrome coronavirus 2</subject><ispartof>European journal of pediatrics, 2022-08, Vol.181 (8), p.3175-3191</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. corrected publication 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. corrected publication 2022.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022, corrected publication 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-d3d94aa93452ef318896186960281fda12e5703956aa30fb4ae066d676e7e15a3</citedby><cites>FETCH-LOGICAL-c404t-d3d94aa93452ef318896186960281fda12e5703956aa30fb4ae066d676e7e15a3</cites><orcidid>0000-0002-0339-0134</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00431-022-04494-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00431-022-04494-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35585256$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suskun, Cansu</creatorcontrib><creatorcontrib>Kilic, Omer</creatorcontrib><creatorcontrib>Yilmaz Ciftdogan, Dilek</creatorcontrib><creatorcontrib>Guven, Sirin</creatorcontrib><creatorcontrib>Karbuz, Adem</creatorcontrib><creatorcontrib>Ozkaya Parlakay, Aslinur</creatorcontrib><creatorcontrib>Kara, Yalcın</creatorcontrib><creatorcontrib>Kacmaz, Ebru</creatorcontrib><creatorcontrib>Sahin, Aslihan</creatorcontrib><creatorcontrib>Boga, Aysun</creatorcontrib><creatorcontrib>Kizmaz Isancli, Didem</creatorcontrib><creatorcontrib>Gulhan, Belgin</creatorcontrib><creatorcontrib>Kanik-Yuksek, Saliha</creatorcontrib><creatorcontrib>Kiral, Eylem</creatorcontrib><creatorcontrib>Bozan, Gurkan</creatorcontrib><creatorcontrib>Arslanoglu, Mehmet Ozgür</creatorcontrib><creatorcontrib>Kizil, Mahmut Can</creatorcontrib><creatorcontrib>Dinleyici, Meltem</creatorcontrib><creatorcontrib>Us, Tercan</creatorcontrib><creatorcontrib>Varis, Ahmet</creatorcontrib><creatorcontrib>Kaya, Mucahit</creatorcontrib><creatorcontrib>Vandenplas, Yvan</creatorcontrib><creatorcontrib>Dinleyici, Ener Cagri</creatorcontrib><title>Intestinal microbiota composition of children with infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and multisystem inflammatory syndrome (MIS-C)</title><title>European journal of pediatrics</title><addtitle>Eur J Pediatr</addtitle><addtitle>Eur J Pediatr</addtitle><description>Microbiota composition may play a role in the development, prognosis, or post-infection of COVID-19. There are studies evaluating the microbiota composition at the time of diagnosis and during the course of COVID-19, especially in adults, while studies in children are limited and no study available in children with multisystem inflammatory syndrome in children (MIS-C). This study was planned to compare intestinal microbiota composition in children diagnosed with MIS-C and acute COVID-19 infection with healthy children. In this prospective multicenter study, 25 children diagnosed with MIS-C, 20 with COVID-19 infection, and 19 healthy children were included. Intestinal microbiota composition was evaluated by 16 s rRNA gene sequencing. We observed changes of diversity, richness, and composition of intestinal microbiota in MIS-C cases compared to COVID-19 cases and in the healthy controls. The Shannon index was higher in the MIS-C group than the healthy controls (
p
< 0.01). At phylum level, in the MIS-C group, a significantly higher relative abundance of Bacteroidetes and lower abundance of Firmicutes was found compared to the control group. Intestinal microbiota composition changed in MIS-C cases compared to COVID-19 and healthy controls, and
Faecalibacterium prausnitzii
decreased;
Bacteroides uniformis
,
Bacteroides plebeius
,
Clostridium ramosum
,
Eubacterium dolichum
,
Eggerthella lenta
,
Bacillus thermoamylovorans
,
Prevotella tannerae
, and
Bacteroides coprophilus
were dominant in children with MIS-C. At species level, we observed decreased
Faecalibacterium prausnitzii
,
and
increased
Eubacterium dolichum
,
Eggerthella lenta
, and
Bacillus thermoamylovorans in children
with MIS-C and increased
Bifidobacterium adolescentis
and
Dorea formicigenerasus
in the COVID-19 group. Our study is the first to evaluate the microbiota composition in MIS-C cases. There is a substantial change in the composition of the gut microbiota: (1) reduction of
F. prausnitzii
in children with MIS-C and COVID-19; (2) an increase of
Eggerthella lenta
which is related with autoimmunity; and (3) the predominance of
E. dolichum
is associated with metabolic dysfunctions and obesity in children with MIS-C.
Conclusions
: Alterations of the intestinal microbiota might be part of pathogenesis of predisposing factor for MIS-C. It would be beneficial to conduct more extensive studies on the cause-effect relationship of these changes in microbiota composition and their effects on long-term prognosis.
What is Known:
• Microbiota composition may play a role in the development, prognosis, or post-infection of COVID-19.
•
However, the number of studies on children is limited, and no study on multisystem inflammatory syndrome in children is currently available (MIS-C).
What is New:
• In individuals with MIS-C, the composition of the gut microbiota changed dramatically.
• Decreased Faecalibacterium prausnitzii have been observed, increased Eggerthella lenta, which was previously linked to autoimmunity, and predominance of Eubacterium dolichum which was linked to metabolic dysfunction and obesity.
Graphical abstract</description><subject>Autoimmunity</subject><subject>Bacillus thermoamylovorans</subject><subject>Bacteroides</subject><subject>Children</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Digestive system</subject><subject>Eggerthella lenta</subject><subject>Eubacterium</subject><subject>Faecalibacterium prausnitzii</subject><subject>Gastrointestinal tract</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Intestinal microflora</subject><subject>Intestine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Microbiota</subject><subject>Multisystem inflammatory syndrome in children</subject><subject>Obesity</subject><subject>Original</subject><subject>Original Article</subject><subject>Pediatrics</subject><subject>Prognosis</subject><subject>rRNA</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><issn>1432-1076</issn><issn>0340-6199</issn><issn>1432-1076</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9ks1uEzEUhUcIREvhBVggS2zSxYD_xmNvkKoISqQiJApsLWfmTuNqbAfbkyrvxEPWSUopXbCyrfudc23fU1WvCX5HMG7fJ4w5IzWmtMacK16rJ9Ux4YzWBLfi6YP9UfUipWtcRIrI59URaxrZ0EYcV78XPkPK1psROdvFsLQhG9QFtw7JZhs8CgPqVnbsI3h0Y_MKWT9Aty_tjwk2EAGZbsqAIqS1jSaHuEVp6_sYHBS3GLzZ2DglRNHs8uzbZT0PP2t6iozvkZvGbNM2ZXA779E498hg9mVRFKcvq2eDGRO8ultPqh-fPn6ff64vvp4v5mcXdccxz3XPesWNUYw3FAZGpFSCSKEEppIMvSEUmhYz1QhjGB6W3AAWohetgBZIY9hJ9eHgu56WDvoOfI5m1OtonYlbHYzV_1a8XemrsNGKkBZLUQxmdwYx_JrK_2pnUwfjaDyEKWkqhFBYtJIX9O0j9DpMsYxjRynJWENlWyh6oMqEUoow3F-GYL0Lgz6EQZcw6H0YtCqiNw-fcS_5M_0CsAOQSslfQfzb-z-2t-2pwuw</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Suskun, Cansu</creator><creator>Kilic, Omer</creator><creator>Yilmaz Ciftdogan, Dilek</creator><creator>Guven, Sirin</creator><creator>Karbuz, Adem</creator><creator>Ozkaya Parlakay, Aslinur</creator><creator>Kara, Yalcın</creator><creator>Kacmaz, Ebru</creator><creator>Sahin, Aslihan</creator><creator>Boga, Aysun</creator><creator>Kizmaz Isancli, Didem</creator><creator>Gulhan, Belgin</creator><creator>Kanik-Yuksek, Saliha</creator><creator>Kiral, Eylem</creator><creator>Bozan, Gurkan</creator><creator>Arslanoglu, Mehmet Ozgür</creator><creator>Kizil, Mahmut Can</creator><creator>Dinleyici, Meltem</creator><creator>Us, Tercan</creator><creator>Varis, Ahmet</creator><creator>Kaya, Mucahit</creator><creator>Vandenplas, Yvan</creator><creator>Dinleyici, Ener Cagri</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0339-0134</orcidid></search><sort><creationdate>20220801</creationdate><title>Intestinal microbiota composition of children with infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and multisystem inflammatory syndrome (MIS-C)</title><author>Suskun, Cansu ; Kilic, Omer ; Yilmaz Ciftdogan, Dilek ; Guven, Sirin ; Karbuz, Adem ; Ozkaya Parlakay, Aslinur ; Kara, Yalcın ; Kacmaz, Ebru ; Sahin, Aslihan ; Boga, Aysun ; Kizmaz Isancli, Didem ; Gulhan, Belgin ; Kanik-Yuksek, Saliha ; Kiral, Eylem ; Bozan, Gurkan ; Arslanoglu, Mehmet Ozgür ; Kizil, Mahmut Can ; Dinleyici, Meltem ; Us, Tercan ; Varis, Ahmet ; Kaya, Mucahit ; Vandenplas, Yvan ; Dinleyici, Ener Cagri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-d3d94aa93452ef318896186960281fda12e5703956aa30fb4ae066d676e7e15a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Autoimmunity</topic><topic>Bacillus thermoamylovorans</topic><topic>Bacteroides</topic><topic>Children</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Digestive system</topic><topic>Eggerthella lenta</topic><topic>Eubacterium</topic><topic>Faecalibacterium prausnitzii</topic><topic>Gastrointestinal tract</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Intestinal microflora</topic><topic>Intestine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Microbiota</topic><topic>Multisystem inflammatory syndrome in children</topic><topic>Obesity</topic><topic>Original</topic><topic>Original Article</topic><topic>Pediatrics</topic><topic>Prognosis</topic><topic>rRNA</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suskun, Cansu</creatorcontrib><creatorcontrib>Kilic, Omer</creatorcontrib><creatorcontrib>Yilmaz Ciftdogan, Dilek</creatorcontrib><creatorcontrib>Guven, Sirin</creatorcontrib><creatorcontrib>Karbuz, Adem</creatorcontrib><creatorcontrib>Ozkaya Parlakay, Aslinur</creatorcontrib><creatorcontrib>Kara, Yalcın</creatorcontrib><creatorcontrib>Kacmaz, Ebru</creatorcontrib><creatorcontrib>Sahin, Aslihan</creatorcontrib><creatorcontrib>Boga, Aysun</creatorcontrib><creatorcontrib>Kizmaz Isancli, Didem</creatorcontrib><creatorcontrib>Gulhan, Belgin</creatorcontrib><creatorcontrib>Kanik-Yuksek, Saliha</creatorcontrib><creatorcontrib>Kiral, Eylem</creatorcontrib><creatorcontrib>Bozan, Gurkan</creatorcontrib><creatorcontrib>Arslanoglu, Mehmet Ozgür</creatorcontrib><creatorcontrib>Kizil, Mahmut Can</creatorcontrib><creatorcontrib>Dinleyici, Meltem</creatorcontrib><creatorcontrib>Us, Tercan</creatorcontrib><creatorcontrib>Varis, Ahmet</creatorcontrib><creatorcontrib>Kaya, Mucahit</creatorcontrib><creatorcontrib>Vandenplas, Yvan</creatorcontrib><creatorcontrib>Dinleyici, Ener Cagri</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database (Proquest)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Family Health Database (Proquest)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suskun, Cansu</au><au>Kilic, Omer</au><au>Yilmaz Ciftdogan, Dilek</au><au>Guven, Sirin</au><au>Karbuz, Adem</au><au>Ozkaya Parlakay, Aslinur</au><au>Kara, Yalcın</au><au>Kacmaz, Ebru</au><au>Sahin, Aslihan</au><au>Boga, Aysun</au><au>Kizmaz Isancli, Didem</au><au>Gulhan, Belgin</au><au>Kanik-Yuksek, Saliha</au><au>Kiral, Eylem</au><au>Bozan, Gurkan</au><au>Arslanoglu, Mehmet Ozgür</au><au>Kizil, Mahmut Can</au><au>Dinleyici, Meltem</au><au>Us, Tercan</au><au>Varis, Ahmet</au><au>Kaya, Mucahit</au><au>Vandenplas, Yvan</au><au>Dinleyici, Ener Cagri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intestinal microbiota composition of children with infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and multisystem inflammatory syndrome (MIS-C)</atitle><jtitle>European journal of pediatrics</jtitle><stitle>Eur J Pediatr</stitle><addtitle>Eur J Pediatr</addtitle><date>2022-08-01</date><risdate>2022</risdate><volume>181</volume><issue>8</issue><spage>3175</spage><epage>3191</epage><pages>3175-3191</pages><issn>1432-1076</issn><issn>0340-6199</issn><eissn>1432-1076</eissn><abstract>Microbiota composition may play a role in the development, prognosis, or post-infection of COVID-19. There are studies evaluating the microbiota composition at the time of diagnosis and during the course of COVID-19, especially in adults, while studies in children are limited and no study available in children with multisystem inflammatory syndrome in children (MIS-C). This study was planned to compare intestinal microbiota composition in children diagnosed with MIS-C and acute COVID-19 infection with healthy children. In this prospective multicenter study, 25 children diagnosed with MIS-C, 20 with COVID-19 infection, and 19 healthy children were included. Intestinal microbiota composition was evaluated by 16 s rRNA gene sequencing. We observed changes of diversity, richness, and composition of intestinal microbiota in MIS-C cases compared to COVID-19 cases and in the healthy controls. The Shannon index was higher in the MIS-C group than the healthy controls (
p
< 0.01). At phylum level, in the MIS-C group, a significantly higher relative abundance of Bacteroidetes and lower abundance of Firmicutes was found compared to the control group. Intestinal microbiota composition changed in MIS-C cases compared to COVID-19 and healthy controls, and
Faecalibacterium prausnitzii
decreased;
Bacteroides uniformis
,
Bacteroides plebeius
,
Clostridium ramosum
,
Eubacterium dolichum
,
Eggerthella lenta
,
Bacillus thermoamylovorans
,
Prevotella tannerae
, and
Bacteroides coprophilus
were dominant in children with MIS-C. At species level, we observed decreased
Faecalibacterium prausnitzii
,
and
increased
Eubacterium dolichum
,
Eggerthella lenta
, and
Bacillus thermoamylovorans in children
with MIS-C and increased
Bifidobacterium adolescentis
and
Dorea formicigenerasus
in the COVID-19 group. Our study is the first to evaluate the microbiota composition in MIS-C cases. There is a substantial change in the composition of the gut microbiota: (1) reduction of
F. prausnitzii
in children with MIS-C and COVID-19; (2) an increase of
Eggerthella lenta
which is related with autoimmunity; and (3) the predominance of
E. dolichum
is associated with metabolic dysfunctions and obesity in children with MIS-C.
Conclusions
: Alterations of the intestinal microbiota might be part of pathogenesis of predisposing factor for MIS-C. It would be beneficial to conduct more extensive studies on the cause-effect relationship of these changes in microbiota composition and their effects on long-term prognosis.
What is Known:
• Microbiota composition may play a role in the development, prognosis, or post-infection of COVID-19.
•
However, the number of studies on children is limited, and no study on multisystem inflammatory syndrome in children is currently available (MIS-C).
What is New:
• In individuals with MIS-C, the composition of the gut microbiota changed dramatically.
• Decreased Faecalibacterium prausnitzii have been observed, increased Eggerthella lenta, which was previously linked to autoimmunity, and predominance of Eubacterium dolichum which was linked to metabolic dysfunction and obesity.
Graphical abstract</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35585256</pmid><doi>10.1007/s00431-022-04494-9</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0002-0339-0134</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1432-1076 |
| ispartof | European journal of pediatrics, 2022-08, Vol.181 (8), p.3175-3191 |
| issn | 1432-1076 0340-6199 1432-1076 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9117086 |
| source | SpringerLink_现刊 |
| subjects | Autoimmunity Bacillus thermoamylovorans Bacteroides Children Coronaviruses COVID-19 Digestive system Eggerthella lenta Eubacterium Faecalibacterium prausnitzii Gastrointestinal tract Infections Inflammation Intestinal microflora Intestine Medicine Medicine & Public Health Metabolism Microbiota Multisystem inflammatory syndrome in children Obesity Original Original Article Pediatrics Prognosis rRNA Severe acute respiratory syndrome coronavirus 2 |
| title | Intestinal microbiota composition of children with infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and multisystem inflammatory syndrome (MIS-C) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T07%3A21%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intestinal%20microbiota%20composition%20of%20children%20with%20infection%20with%20severe%20acute%20respiratory%20syndrome%20coronavirus%202%20(SARS-CoV-2)%20and%20multisystem%20inflammatory%20syndrome%20(MIS-C)&rft.jtitle=European%20journal%20of%20pediatrics&rft.au=Suskun,%20Cansu&rft.date=2022-08-01&rft.volume=181&rft.issue=8&rft.spage=3175&rft.epage=3191&rft.pages=3175-3191&rft.issn=1432-1076&rft.eissn=1432-1076&rft_id=info:doi/10.1007/s00431-022-04494-9&rft_dat=%3Cproquest_pubme%3E2666906784%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2698335287&rft_id=info:pmid/35585256&rfr_iscdi=true |