Characterization of Glycosaminoglycan Disaccharide Composition in Astrocyte Primary Cultures and the Cortex of Neonatal Rats

Astrocytes are major producers of the extracellular matrix (ECM), which is involved in the plasticity of the developing brain. In utero alcohol exposure alters neuronal plasticity. Glycosaminoglycans (GAGs) are a family of polysaccharides present in the extracellular space; chondroitin sulfate (CS)-...

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Veröffentlicht in:	Neurochemical research 2021-03, Vol.46 (3), p.595-610
Hauptverfasser:	Zhang, Xiaolu, Hashimoto, Joel G., Han, Xiaorui, Zhang, Fuming, Linhardt, Robert J., Guizzetti, Marina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Astrocytes Astrocytes - chemistry Astrocytes - drug effects Astrocytes - metabolism Biochemistry Biomedical and Life Sciences Biomedicine Biosynthesis Brain Brevican - metabolism Cell Biology Cerebral Cortex - chemistry Cerebral Cortex - drug effects Cerebral Cortex - metabolism Chondroitin sulfate Chondroitin Sulfates - analysis Chondroitin Sulfates - metabolism Core protein Cortex Disaccharides Disaccharides - analysis Disaccharides - metabolism Ethanol Ethanol - pharmacology Extracellular matrix Female Gene expression Glycosaminoglycans Glycosaminoglycans - analysis Glycosaminoglycans - metabolism Heparan sulfate Heparitin Sulfate - analysis Heparitin Sulfate - metabolism Hyaluronic acid Hyaluronic Acid - analysis Hyaluronic Acid - metabolism Intrauterine exposure Neonates Neurocan Neurocan - metabolism Neurochemistry Neurology Neuroplasticity Neurosciences Original Paper Polysaccharides Pregnancy Proteins Proteoglycans Rats Rats, Sprague-Dawley Saccharides Sulfates
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