Assessing the Causal Role of Sleep Traits on Glycated Hemoglobin: A Mendelian Randomization Study

To examine the effects of sleep traits on glycated hemoglobin (HbA1c). This study triangulated evidence across multivariable regression (MVR) and one- (1SMR) and two-sample Mendelian randomization (2SMR) including sensitivity analyses on the effects of five self-reported sleep traits (i.e., insomnia...

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Veröffentlicht in:	Diabetes care 2022-04, Vol.45 (4), p.772-781
Hauptverfasser:	Liu, Junxi, Richmond, Rebecca C, Bowden, Jack, Barry, Ciarrah, Dashti, Hassan S, Daghlas, Iyas, Lane, Jacqueline M, Jones, Samuel E, Wood, Andrew R, Frayling, Timothy M, Wright, Alison K, Carr, Matthew J, Anderson, Simon G, Emsley, Richard A, Ray, David W, Weedon, Michael N, Saxena, Richa, Lawlor, Deborah A, Rutter, Martin K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 Epidemiology/Health Services Research Female Females Genome-Wide Association Study Genomes Glycated Hemoglobin - analysis Glycated Hemoglobin - genetics Hemoglobin Humans Hyperglycemia Insomnia Insulin Male Mendelian Randomization Analysis Middle Aged Randomization Research design Sensitivity analysis Sleep Sleep - genetics Sleep and wakefulness Sleep deprivation Sleep disorders Sleep Initiation and Maintenance Disorders - genetics Sleepiness
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