An Exaggerated Monocyte-Derived Cytokine Response to Candida Hyphae in Patients With Recurrent Vulvovaginal Candidiasis

Abstract Background Recurrent vulvovaginal candidiasis (RVVC) affects up to 8% of women. The immunopathogenesis is poorly understood but it has been suggested that RVVC might be due to dysregulated innate immune response. The aim of this study was to compare cytokine profiles in stimulated primary m...

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Veröffentlicht in:	The Journal of infectious diseases 2022-05, Vol.225 (10), p.1796-1806
Hauptverfasser:	Rosati, Diletta, Bruno, Mariolina, Jaeger, Martin, Kullberg, Bart-Jan, van de Veerdonk, Frank, Netea, Mihai G, ten Oever, Jaap
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Antigens Candida Candidiasis Cytokines Enzyme-linked immunosorbent assay Helper cells Hyphae IL-1β Immune response Immunopathogenesis Innate immunity Interleukin 1 receptor antagonist Interleukin 1 receptors Interleukin 10 Interleukin 6 Leukocytes (mononuclear) Lymphocytes T Major and Brief Reports Monocytes Pathogens Tumor necrosis factor-TNF Tumor necrosis factor-α
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