Sex differences in M2 polarization, chemokine and IL-4 receptors in monocytes and macrophages from asthmatics

[Display omitted] •Monocytes and macrophages are in part responsible for sex differences in asthma.•Greater expression of γC and CX3CR1 on monocytes from asthmatic women than men.•Higher IL-4-induced M2 gene expression in macrophages from asthmatic women than men.•Reduced SOCS1 in lung macrophages f...

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Veröffentlicht in:	Cellular immunology 2021-02, Vol.360, p.104252-104252, Article 104252
Hauptverfasser:	Becerra-Díaz, Mireya, Lerner, Andrew D., Yu, Diana H., Thiboutot, Jeffrey P., Liu, Mark C., Yarmus, Lonny B., Bose, Sonali, Heller, Nicola M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergic lung inflammation Alveolar macrophages Asthma Asthma - immunology Asthma - metabolism Asthma - physiopathology Cell Polarity - physiology Cell recruitment Chemokine Chemokines - metabolism Female Gene Expression - genetics Hormones Humans IL-4 Interleukin-4 - immunology Lung - pathology Macrophage Activation - immunology Macrophages - immunology Macrophages - metabolism Male Middle Aged Monocytes Monocytes - immunology Monocytes - metabolism Phenotype Receptors, Chemokine - metabolism Receptors, Interleukin-4 - immunology Receptors, Interleukin-4 - metabolism Sex differences Sex Factors Signal Transduction
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