Complete Response Induced by Concurrent Chemoradiotherapy in a Patient with NUT Carcinoma
An 18-year-old man presented with sudden vision loss in his left eye. Magnetic resonance imaging revealed a tumor that had invaded the left optic nerve, originating from the left posterior ethmoid sinus. Immunohistochemical analyses identified positive staining for NUT protein in the nuclei of tumor...
Gespeichert in:
| Veröffentlicht in: | Internal Medicine 2022/04/15, Vol.61(8), pp.1299-1304 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1304 |
|---|---|
| container_issue | 8 |
| container_start_page | 1299 |
| container_title | Internal Medicine |
| container_volume | 61 |
| creator | Muramatsu, Joji Takada, Kohichi Sugita, Shintaro Tsuchiya, Takaaki Yamamoto, Keisuke Takagi, Masaru Murase, Kazuyuki Ameda, Saki Arihara, Yohei Miyanishi, Koji Sakata, Koh-Ichi Kato, Junji |
| description | An 18-year-old man presented with sudden vision loss in his left eye. Magnetic resonance imaging revealed a tumor that had invaded the left optic nerve, originating from the left posterior ethmoid sinus. Immunohistochemical analyses identified positive staining for NUT protein in the nuclei of tumor cells. We diagnosed locally advanced NUT carcinoma (NC) and initiated concurrent chemoradiotherapy (CCRT), consisting of chemotherapy with vincristine, doxorubicin, and cyclophosphamide, alternating with ifosphamide and etoposide, plus radiation therapy. The patient achieved a complete response. CCRT can be a useful treatment option for adolescent and young-adult patients with locally advanced unresectable NC. |
| doi_str_mv | 10.2169/internalmedicine.7741-21 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9107965</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2580026750</sourcerecordid><originalsourceid>FETCH-LOGICAL-c609t-e6660ab9bd19ebf5c99d314cd0148cb3ea114cf57df361f386a0b425f75e436f3</originalsourceid><addsrcrecordid>eNplkUFr3DAQhUVpabZJ_0IR9NKLU8myZetSKCZNAiEpITn0JGR5HGuxJVeSW_bfV2a3S5tcRoj3zdNoHkKYkvOccvHZ2AjeqnGCzmhj4byqCprl9BXaUFaIrMpZ-RptiKB1lqdygt6FsCWE1ZXI36ITVnBa1jnZoB-Nm-YRIuB7CLOzAfC17RYNHW53uHFWL96DjbgZYHJedcbFAbyad9hYrPB3Fc0q_zZxwLePD7hRPk3kJnWG3vRqDPD-cJ6ix28XD81VdnN3ed18vck0JyJmwDknqhVtRwW0famF6BgtdEdoUeuWgaLp1pdV1zNOe1ZzRdoiL_uqhILxnp2iL3vfeWnTPnSaxqtRzt5Myu-kU0b-r1gzyCf3SwpKKsHLZPDpYODdzwVClJMJGsZRWXBLkHlZE5LzqiQJ_fgM3bplDSJRPC1UcFqvVL2ntHcheOiPw1Ai1_zk8_zkml-SUuuHfz9zbPwbWAJu98A2RPUER0D5aPQIL505lfVaDi8cQT0oL8GyPxmGun8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2658296180</pqid></control><display><type>article</type><title>Complete Response Induced by Concurrent Chemoradiotherapy in a Patient with NUT Carcinoma</title><source>J-STAGE Free</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Muramatsu, Joji ; Takada, Kohichi ; Sugita, Shintaro ; Tsuchiya, Takaaki ; Yamamoto, Keisuke ; Takagi, Masaru ; Murase, Kazuyuki ; Ameda, Saki ; Arihara, Yohei ; Miyanishi, Koji ; Sakata, Koh-Ichi ; Kato, Junji</creator><creatorcontrib>Muramatsu, Joji ; Takada, Kohichi ; Sugita, Shintaro ; Tsuchiya, Takaaki ; Yamamoto, Keisuke ; Takagi, Masaru ; Murase, Kazuyuki ; Ameda, Saki ; Arihara, Yohei ; Miyanishi, Koji ; Sakata, Koh-Ichi ; Kato, Junji</creatorcontrib><description>An 18-year-old man presented with sudden vision loss in his left eye. Magnetic resonance imaging revealed a tumor that had invaded the left optic nerve, originating from the left posterior ethmoid sinus. Immunohistochemical analyses identified positive staining for NUT protein in the nuclei of tumor cells. We diagnosed locally advanced NUT carcinoma (NC) and initiated concurrent chemoradiotherapy (CCRT), consisting of chemotherapy with vincristine, doxorubicin, and cyclophosphamide, alternating with ifosphamide and etoposide, plus radiation therapy. The patient achieved a complete response. CCRT can be a useful treatment option for adolescent and young-adult patients with locally advanced unresectable NC.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.7741-21</identifier><identifier>PMID: 34615820</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Case Report ; Chemoradiotherapy ; Chemotherapy ; concurrent chemoradiotherapy ; Cyclophosphamide ; Doxorubicin ; Etoposide ; Internal medicine ; Magnetic resonance imaging ; NUT carcinoma ; Optic nerve ; Patients ; Radiation therapy ; Tumor cells ; VDC-IE regimen ; Vincristine</subject><ispartof>Internal Medicine, 2022/04/15, Vol.61(8), pp.1299-1304</ispartof><rights>2022 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2022</rights><rights>Copyright © 2022 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c609t-e6660ab9bd19ebf5c99d314cd0148cb3ea114cf57df361f386a0b425f75e436f3</citedby><cites>FETCH-LOGICAL-c609t-e6660ab9bd19ebf5c99d314cd0148cb3ea114cf57df361f386a0b425f75e436f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107965/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107965/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1877,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34615820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muramatsu, Joji</creatorcontrib><creatorcontrib>Takada, Kohichi</creatorcontrib><creatorcontrib>Sugita, Shintaro</creatorcontrib><creatorcontrib>Tsuchiya, Takaaki</creatorcontrib><creatorcontrib>Yamamoto, Keisuke</creatorcontrib><creatorcontrib>Takagi, Masaru</creatorcontrib><creatorcontrib>Murase, Kazuyuki</creatorcontrib><creatorcontrib>Ameda, Saki</creatorcontrib><creatorcontrib>Arihara, Yohei</creatorcontrib><creatorcontrib>Miyanishi, Koji</creatorcontrib><creatorcontrib>Sakata, Koh-Ichi</creatorcontrib><creatorcontrib>Kato, Junji</creatorcontrib><title>Complete Response Induced by Concurrent Chemoradiotherapy in a Patient with NUT Carcinoma</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>An 18-year-old man presented with sudden vision loss in his left eye. Magnetic resonance imaging revealed a tumor that had invaded the left optic nerve, originating from the left posterior ethmoid sinus. Immunohistochemical analyses identified positive staining for NUT protein in the nuclei of tumor cells. We diagnosed locally advanced NUT carcinoma (NC) and initiated concurrent chemoradiotherapy (CCRT), consisting of chemotherapy with vincristine, doxorubicin, and cyclophosphamide, alternating with ifosphamide and etoposide, plus radiation therapy. The patient achieved a complete response. CCRT can be a useful treatment option for adolescent and young-adult patients with locally advanced unresectable NC.</description><subject>Case Report</subject><subject>Chemoradiotherapy</subject><subject>Chemotherapy</subject><subject>concurrent chemoradiotherapy</subject><subject>Cyclophosphamide</subject><subject>Doxorubicin</subject><subject>Etoposide</subject><subject>Internal medicine</subject><subject>Magnetic resonance imaging</subject><subject>NUT carcinoma</subject><subject>Optic nerve</subject><subject>Patients</subject><subject>Radiation therapy</subject><subject>Tumor cells</subject><subject>VDC-IE regimen</subject><subject>Vincristine</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNplkUFr3DAQhUVpabZJ_0IR9NKLU8myZetSKCZNAiEpITn0JGR5HGuxJVeSW_bfV2a3S5tcRoj3zdNoHkKYkvOccvHZ2AjeqnGCzmhj4byqCprl9BXaUFaIrMpZ-RptiKB1lqdygt6FsCWE1ZXI36ITVnBa1jnZoB-Nm-YRIuB7CLOzAfC17RYNHW53uHFWL96DjbgZYHJedcbFAbyad9hYrPB3Fc0q_zZxwLePD7hRPk3kJnWG3vRqDPD-cJ6ix28XD81VdnN3ed18vck0JyJmwDknqhVtRwW0famF6BgtdEdoUeuWgaLp1pdV1zNOe1ZzRdoiL_uqhILxnp2iL3vfeWnTPnSaxqtRzt5Myu-kU0b-r1gzyCf3SwpKKsHLZPDpYODdzwVClJMJGsZRWXBLkHlZE5LzqiQJ_fgM3bplDSJRPC1UcFqvVL2ntHcheOiPw1Ai1_zk8_zkml-SUuuHfz9zbPwbWAJu98A2RPUER0D5aPQIL505lfVaDi8cQT0oL8GyPxmGun8</recordid><startdate>20220415</startdate><enddate>20220415</enddate><creator>Muramatsu, Joji</creator><creator>Takada, Kohichi</creator><creator>Sugita, Shintaro</creator><creator>Tsuchiya, Takaaki</creator><creator>Yamamoto, Keisuke</creator><creator>Takagi, Masaru</creator><creator>Murase, Kazuyuki</creator><creator>Ameda, Saki</creator><creator>Arihara, Yohei</creator><creator>Miyanishi, Koji</creator><creator>Sakata, Koh-Ichi</creator><creator>Kato, Junji</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220415</creationdate><title>Complete Response Induced by Concurrent Chemoradiotherapy in a Patient with NUT Carcinoma</title><author>Muramatsu, Joji ; Takada, Kohichi ; Sugita, Shintaro ; Tsuchiya, Takaaki ; Yamamoto, Keisuke ; Takagi, Masaru ; Murase, Kazuyuki ; Ameda, Saki ; Arihara, Yohei ; Miyanishi, Koji ; Sakata, Koh-Ichi ; Kato, Junji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c609t-e6660ab9bd19ebf5c99d314cd0148cb3ea114cf57df361f386a0b425f75e436f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Case Report</topic><topic>Chemoradiotherapy</topic><topic>Chemotherapy</topic><topic>concurrent chemoradiotherapy</topic><topic>Cyclophosphamide</topic><topic>Doxorubicin</topic><topic>Etoposide</topic><topic>Internal medicine</topic><topic>Magnetic resonance imaging</topic><topic>NUT carcinoma</topic><topic>Optic nerve</topic><topic>Patients</topic><topic>Radiation therapy</topic><topic>Tumor cells</topic><topic>VDC-IE regimen</topic><topic>Vincristine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muramatsu, Joji</creatorcontrib><creatorcontrib>Takada, Kohichi</creatorcontrib><creatorcontrib>Sugita, Shintaro</creatorcontrib><creatorcontrib>Tsuchiya, Takaaki</creatorcontrib><creatorcontrib>Yamamoto, Keisuke</creatorcontrib><creatorcontrib>Takagi, Masaru</creatorcontrib><creatorcontrib>Murase, Kazuyuki</creatorcontrib><creatorcontrib>Ameda, Saki</creatorcontrib><creatorcontrib>Arihara, Yohei</creatorcontrib><creatorcontrib>Miyanishi, Koji</creatorcontrib><creatorcontrib>Sakata, Koh-Ichi</creatorcontrib><creatorcontrib>Kato, Junji</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muramatsu, Joji</au><au>Takada, Kohichi</au><au>Sugita, Shintaro</au><au>Tsuchiya, Takaaki</au><au>Yamamoto, Keisuke</au><au>Takagi, Masaru</au><au>Murase, Kazuyuki</au><au>Ameda, Saki</au><au>Arihara, Yohei</au><au>Miyanishi, Koji</au><au>Sakata, Koh-Ichi</au><au>Kato, Junji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Complete Response Induced by Concurrent Chemoradiotherapy in a Patient with NUT Carcinoma</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2022-04-15</date><risdate>2022</risdate><volume>61</volume><issue>8</issue><spage>1299</spage><epage>1304</epage><pages>1299-1304</pages><artnum>7741-21</artnum><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>An 18-year-old man presented with sudden vision loss in his left eye. Magnetic resonance imaging revealed a tumor that had invaded the left optic nerve, originating from the left posterior ethmoid sinus. Immunohistochemical analyses identified positive staining for NUT protein in the nuclei of tumor cells. We diagnosed locally advanced NUT carcinoma (NC) and initiated concurrent chemoradiotherapy (CCRT), consisting of chemotherapy with vincristine, doxorubicin, and cyclophosphamide, alternating with ifosphamide and etoposide, plus radiation therapy. The patient achieved a complete response. CCRT can be a useful treatment option for adolescent and young-adult patients with locally advanced unresectable NC.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>34615820</pmid><doi>10.2169/internalmedicine.7741-21</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0918-2918 |
| ispartof | Internal Medicine, 2022/04/15, Vol.61(8), pp.1299-1304 |
| issn | 0918-2918 1349-7235 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9107965 |
| source | J-STAGE Free; PubMed Central; PubMed Central Open Access |
| subjects | Case Report Chemoradiotherapy Chemotherapy concurrent chemoradiotherapy Cyclophosphamide Doxorubicin Etoposide Internal medicine Magnetic resonance imaging NUT carcinoma Optic nerve Patients Radiation therapy Tumor cells VDC-IE regimen Vincristine |
| title | Complete Response Induced by Concurrent Chemoradiotherapy in a Patient with NUT Carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T08%3A55%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Complete%20Response%20Induced%20by%20Concurrent%20Chemoradiotherapy%20in%20a%20Patient%20with%20NUT%20Carcinoma&rft.jtitle=Internal%20Medicine&rft.au=Muramatsu,%20Joji&rft.date=2022-04-15&rft.volume=61&rft.issue=8&rft.spage=1299&rft.epage=1304&rft.pages=1299-1304&rft.artnum=7741-21&rft.issn=0918-2918&rft.eissn=1349-7235&rft_id=info:doi/10.2169/internalmedicine.7741-21&rft_dat=%3Cproquest_pubme%3E2580026750%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2658296180&rft_id=info:pmid/34615820&rfr_iscdi=true |