Extracellular vesicles mediate cellular interactions in renal diseases—Novel views of intercellular communications in the kidney
The kidney is a complicated and important internal organ receiving approximately 20% of the cardiac output and mediates numerous pathophysiologic actions. These include selectively filtering macromolecules of the blood, exquisite reclaimation of electrolyctes, urine concentration via an elegant osmo...
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| Veröffentlicht in: | Journal of cellular physiology 2021-08, Vol.236 (8), p.5482-5494 |
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| description | The kidney is a complicated and important internal organ receiving approximately 20% of the cardiac output and mediates numerous pathophysiologic actions. These include selectively filtering macromolecules of the blood, exquisite reclaimation of electrolyctes, urine concentration via an elegant osmotic mechanism, and excretion of an acid load. In addition, the renal tubules carry out secretory functions and produce hormones and cytokines. The kidney receives innervation and hormonal regulation. Therefore, dysfunction of the kidney leads to retention of metabolic waste products, and/or significant proteinuria and hematuria. In the past several decades, the role of extracellular vesicles (EVs) in intercellular communications, and the uptake of EVs by recipient cells through phagocytosis and endocytosis have been elucidated. The new knowledge on EVs expands over the classical mechanisms of cellular interaction, and may change our way of thinking of renal pathophysiology in the subcellular scale. Based on some ultrastructural discoveries in the kidney, this review will focus on the role of EVs in intercellular communications, their internalization by recipient cells, and their relationship to renal pathology.
Graphical
In the past several decades, the role of extracellular vesicles (EV) in intercellular communications, and the uptake of EVs by recipient cells through phagocytosis and endocytosis have been elucidated. The new knowledge on EVs expands over the classical mechanisms of cellular interaction, and may change our way of thinking of renal pathophysiology in the subcellular scale. Based on some ultrastructural discoveries in the kidney, this review will focus on the role of EVs in intercellular communications, their internalization by recipient cells, and their relationship to renal pathology. |
| doi_str_mv | 10.1002/jcp.30268 |
| format | Article |
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Graphical
In the past several decades, the role of extracellular vesicles (EV) in intercellular communications, and the uptake of EVs by recipient cells through phagocytosis and endocytosis have been elucidated. The new knowledge on EVs expands over the classical mechanisms of cellular interaction, and may change our way of thinking of renal pathophysiology in the subcellular scale. Based on some ultrastructural discoveries in the kidney, this review will focus on the role of EVs in intercellular communications, their internalization by recipient cells, and their relationship to renal pathology.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.30268</identifier><identifier>PMID: 33432614</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>and renal disease ; Apoptosis ; Cardiac output ; Cell Communication - physiology ; Communications ; Cytokines ; Cytokines - metabolism ; Electrolytic cells ; Endocytosis ; excetracellular vesicles ; exsomes ; Extracellular vesicles ; Extracellular Vesicles - metabolism ; Hematuria ; Hormones ; Humans ; Innervation ; Internalization ; Kidney - metabolism ; Kidney - pathology ; Kidney diseases ; Kidney Diseases - metabolism ; Kidney Diseases - pathology ; Kidney Tubules - metabolism ; Kidney Tubules - pathology ; Kidneys ; Macromolecules ; Metabolic wastes ; microvesicles ; Phagocytosis ; Proteinuria ; Renal tubules ; Vesicles</subject><ispartof>Journal of cellular physiology, 2021-08, Vol.236 (8), p.5482-5494</ispartof><rights>2021 Wiley Periodicals LLC</rights><rights>2021 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4438-ff7a4f540c25ae73d5f7e2ecd6ad000d023be289d543243217b414b8176b76d73</citedby><cites>FETCH-LOGICAL-c4438-ff7a4f540c25ae73d5f7e2ecd6ad000d023be289d543243217b414b8176b76d73</cites><orcidid>0000-0001-8827-2024</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.30268$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.30268$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33432614$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Ping L.</creatorcontrib><creatorcontrib>Liu, Ming‐Lin</creatorcontrib><title>Extracellular vesicles mediate cellular interactions in renal diseases—Novel views of intercellular communications in the kidney</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>The kidney is a complicated and important internal organ receiving approximately 20% of the cardiac output and mediates numerous pathophysiologic actions. These include selectively filtering macromolecules of the blood, exquisite reclaimation of electrolyctes, urine concentration via an elegant osmotic mechanism, and excretion of an acid load. In addition, the renal tubules carry out secretory functions and produce hormones and cytokines. The kidney receives innervation and hormonal regulation. Therefore, dysfunction of the kidney leads to retention of metabolic waste products, and/or significant proteinuria and hematuria. In the past several decades, the role of extracellular vesicles (EVs) in intercellular communications, and the uptake of EVs by recipient cells through phagocytosis and endocytosis have been elucidated. The new knowledge on EVs expands over the classical mechanisms of cellular interaction, and may change our way of thinking of renal pathophysiology in the subcellular scale. Based on some ultrastructural discoveries in the kidney, this review will focus on the role of EVs in intercellular communications, their internalization by recipient cells, and their relationship to renal pathology.
Graphical
In the past several decades, the role of extracellular vesicles (EV) in intercellular communications, and the uptake of EVs by recipient cells through phagocytosis and endocytosis have been elucidated. The new knowledge on EVs expands over the classical mechanisms of cellular interaction, and may change our way of thinking of renal pathophysiology in the subcellular scale. Based on some ultrastructural discoveries in the kidney, this review will focus on the role of EVs in intercellular communications, their internalization by recipient cells, and their relationship to renal pathology.</description><subject>and renal disease</subject><subject>Apoptosis</subject><subject>Cardiac output</subject><subject>Cell Communication - physiology</subject><subject>Communications</subject><subject>Cytokines</subject><subject>Cytokines - metabolism</subject><subject>Electrolytic cells</subject><subject>Endocytosis</subject><subject>excetracellular vesicles</subject><subject>exsomes</subject><subject>Extracellular vesicles</subject><subject>Extracellular Vesicles - metabolism</subject><subject>Hematuria</subject><subject>Hormones</subject><subject>Humans</subject><subject>Innervation</subject><subject>Internalization</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>Kidney diseases</subject><subject>Kidney Diseases - metabolism</subject><subject>Kidney Diseases - pathology</subject><subject>Kidney Tubules - metabolism</subject><subject>Kidney Tubules - pathology</subject><subject>Kidneys</subject><subject>Macromolecules</subject><subject>Metabolic wastes</subject><subject>microvesicles</subject><subject>Phagocytosis</subject><subject>Proteinuria</subject><subject>Renal tubules</subject><subject>Vesicles</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAUhS0EotPCghdAkdjAIq3_YicbpGpU_lQBC1hbjn1DPTjxYCdTZlfxDDwhT4KHlAiQkCxdWfe7R_fcg9Ajgk8JxvRsY7anDFNR30ErghtZclHRu2iVe6RsKk6O0HFKG4xx0zB2Hx0xxhkVhK_Qt4uvY9QGvJ-8jsUOkjMeUtGDdXqEYum4YYQMji4MKX-KCIP2hXUJdIL04-b727ADX-wcXKcidDO_TJvQ99PgjF7mxysoPjs7wP4Butdpn-DhbT1BH19cfFi_Ki_fvXy9Pr8sDeesLrtOat5VHBtaaZDMVp0ECsYKbbMziylrgdaNrbK3_IhsOeFtTaRopbCSnaDns-52arM9A0N27tU2ul7HvQraqb87g7tSn8JONQTLfMUs8PRWIIYvE6RR9S4dLOoBwpQU5VJSUQmOM_rkH3QTppgvlqmKyroWFTts9GymTAwpReiWZQhWh2RVTlb9Sjazj__cfiF_R5mBsxm4dh72_1dSb9bvZ8mf57CxuA</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Zhang, Ping L.</creator><creator>Liu, Ming‐Lin</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8827-2024</orcidid></search><sort><creationdate>202108</creationdate><title>Extracellular vesicles mediate cellular interactions in renal diseases—Novel views of intercellular communications in the kidney</title><author>Zhang, Ping L. ; Liu, Ming‐Lin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4438-ff7a4f540c25ae73d5f7e2ecd6ad000d023be289d543243217b414b8176b76d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>and renal disease</topic><topic>Apoptosis</topic><topic>Cardiac output</topic><topic>Cell Communication - physiology</topic><topic>Communications</topic><topic>Cytokines</topic><topic>Cytokines - metabolism</topic><topic>Electrolytic cells</topic><topic>Endocytosis</topic><topic>excetracellular vesicles</topic><topic>exsomes</topic><topic>Extracellular vesicles</topic><topic>Extracellular Vesicles - metabolism</topic><topic>Hematuria</topic><topic>Hormones</topic><topic>Humans</topic><topic>Innervation</topic><topic>Internalization</topic><topic>Kidney - metabolism</topic><topic>Kidney - pathology</topic><topic>Kidney diseases</topic><topic>Kidney Diseases - metabolism</topic><topic>Kidney Diseases - pathology</topic><topic>Kidney Tubules - metabolism</topic><topic>Kidney Tubules - pathology</topic><topic>Kidneys</topic><topic>Macromolecules</topic><topic>Metabolic wastes</topic><topic>microvesicles</topic><topic>Phagocytosis</topic><topic>Proteinuria</topic><topic>Renal tubules</topic><topic>Vesicles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Ping L.</creatorcontrib><creatorcontrib>Liu, Ming‐Lin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Ping L.</au><au>Liu, Ming‐Lin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extracellular vesicles mediate cellular interactions in renal diseases—Novel views of intercellular communications in the kidney</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J Cell Physiol</addtitle><date>2021-08</date><risdate>2021</risdate><volume>236</volume><issue>8</issue><spage>5482</spage><epage>5494</epage><pages>5482-5494</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><abstract>The kidney is a complicated and important internal organ receiving approximately 20% of the cardiac output and mediates numerous pathophysiologic actions. These include selectively filtering macromolecules of the blood, exquisite reclaimation of electrolyctes, urine concentration via an elegant osmotic mechanism, and excretion of an acid load. In addition, the renal tubules carry out secretory functions and produce hormones and cytokines. The kidney receives innervation and hormonal regulation. Therefore, dysfunction of the kidney leads to retention of metabolic waste products, and/or significant proteinuria and hematuria. In the past several decades, the role of extracellular vesicles (EVs) in intercellular communications, and the uptake of EVs by recipient cells through phagocytosis and endocytosis have been elucidated. The new knowledge on EVs expands over the classical mechanisms of cellular interaction, and may change our way of thinking of renal pathophysiology in the subcellular scale. Based on some ultrastructural discoveries in the kidney, this review will focus on the role of EVs in intercellular communications, their internalization by recipient cells, and their relationship to renal pathology.
Graphical
In the past several decades, the role of extracellular vesicles (EV) in intercellular communications, and the uptake of EVs by recipient cells through phagocytosis and endocytosis have been elucidated. The new knowledge on EVs expands over the classical mechanisms of cellular interaction, and may change our way of thinking of renal pathophysiology in the subcellular scale. Based on some ultrastructural discoveries in the kidney, this review will focus on the role of EVs in intercellular communications, their internalization by recipient cells, and their relationship to renal pathology.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33432614</pmid><doi>10.1002/jcp.30268</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-8827-2024</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | and renal disease Apoptosis Cardiac output Cell Communication - physiology Communications Cytokines Cytokines - metabolism Electrolytic cells Endocytosis excetracellular vesicles exsomes Extracellular vesicles Extracellular Vesicles - metabolism Hematuria Hormones Humans Innervation Internalization Kidney - metabolism Kidney - pathology Kidney diseases Kidney Diseases - metabolism Kidney Diseases - pathology Kidney Tubules - metabolism Kidney Tubules - pathology Kidneys Macromolecules Metabolic wastes microvesicles Phagocytosis Proteinuria Renal tubules Vesicles |
| title | Extracellular vesicles mediate cellular interactions in renal diseases—Novel views of intercellular communications in the kidney |
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