Correlations between histological characterizations and methylation statuses of tumour suppressor genes in Wilms' tumours

Wilms' tumour is a solid tumour that frequently occurs in children. Genetic changes in WT1 and epigenetic aberrations that affect imprinted control region 1 in WT2 loci are implicated in its aetiology. Moreover, tumour suppressor genes are frequently silenced by methylation in this tumour. In t...

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Veröffentlicht in:	International journal of experimental pathology 2022-06, Vol.103 (3), p.121-128
Hauptverfasser:	Lai, Yen‐Chein, Lu, Meng‐Yao, Wang, Wen‐Chung, Hou, Tai‐Cheng, Kuo, Chen‐Yun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous polyposis coli BRCA1 protein Child Disease management DNA Methylation Epigenetics Gene silencing Genes Genes, Tumor Suppressor Humans Kidney Neoplasms - genetics Kidney Neoplasms - pathology Methylation methylation detection MLH1 protein molecular pathology multiplex ligation‐dependent probe amplification nephroblastoma Original Promoter Regions, Genetic Solid tumors Tumor suppressor genes Tumor Suppressor Proteins Tumorigenesis Tumors tumour suppressor gene Wilms Tumor - genetics Wilms Tumor - pathology Wilms' tumour
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