Novel insights into the SLC7A11-mediated ferroptosis signaling pathways in preeclampsia patients: identifying pannexin 1 and toll-like receptor 4 as innovative prospective diagnostic biomarkers

Purpose Ferroptosis is associated with oxidative stress (OS) and is caused by iron-dependent lipid-peroxidative damage, but its role in PE is unclear. The aim of this study is to determine whether pannexin 1 (Panx1) and toll-like receptor 4 (TLR4) are key regulators of ferroptosis in PE. Methods The...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of assisted reproduction and genetics 2022-05, Vol.39 (5), p.1115-1124
Hauptverfasser:	El-Khalik, Sarah Ragab Abd, Ibrahim, Rowida Raafat, Ghafar, Muhammad Tarek Abdel, Shatat, Doaa, El-Deeb, Omnia Safwat
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating transcription factor 3 Amino Acid Transport System y+ - genetics Amino Acid Transport System y+ - metabolism Apoptosis Biomarkers Biomarkers - metabolism Blood pressure Connexins - genetics Connexins - metabolism Cytokines Female Ferroptosis Ferroptosis - genetics Gene expression Glutathione peroxidase Gynecology Heme Heme oxygenase (decyclizing) Human Genetics Humans Iron Ischemia Lipids Medicine Medicine & Public Health Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Obstetrics Oxidative stress Oxygenase Pathogenesis Placenta Placenta - metabolism Polymerase chain reaction Pre-eclampsia Pre-Eclampsia - diagnosis Pre-Eclampsia - genetics Pre-Eclampsia - metabolism Preeclampsia Pregnancy Prospective Studies Proteins Reproductive Medicine Reproductive Physiology and Disease Sample size Signal Transduction Steroids TLR4 protein Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Toll-like receptors Transcription factors Urine Womens health
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!