Structural basis for tRNA methylthiolation by the radical SAM enzyme MiaB

Numerous post-transcriptional modifications of transfer RNAs have vital roles in translation. The 2-methylthio- N 6 -isopentenyladenosine (ms 2 i 6 A) modification occurs at position 37 (A37) in transfer RNAs that contain adenine in position 36 of the anticodon, and serves to promote efficient A:U c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature (London) 2021-09, Vol.597 (7877), p.566-570
Hauptverfasser:	Esakova, Olga A., Grove, Tyler L., Yennawar, Neela H., Arcinas, Arthur J., Wang, Bo, Krebs, Carsten, Almo, Steven C., Booker, Squire J.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/49/1141 631/535/1266 82/80 82/83 Adenine Adenosine Adenosine - analogs & derivatives Adenosine - metabolism Adenosylmethionine Bacteroides - enzymology Binding Sites Biocatalysis Clusters Cyclin-dependent kinases Enzymes Genetic aspects Humanities and Social Sciences Hydrogen Isopentenyladenosine - metabolism Methyltransferases - chemistry Methyltransferases - metabolism Models, Molecular multidisciplinary Oxygen Physiological aspects Post-transcription Protein Domains Proteins Radicals RNA - metabolism RNA, Transfer - chemistry RNA, Transfer - metabolism RNA-Binding Proteins - chemistry RNA-Binding Proteins - metabolism S-Adenosylmethionine - metabolism Science Science (multidisciplinary) Structure Substrate Specificity Substrates Sulfhydryl Compounds - metabolism Sulfur Sulfurtransferases - chemistry Sulfurtransferases - metabolism Transfer RNA tRNA
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!