Targeting Circulating lncRNA ENST00000538705.1 Relieves Acute Coronary Syndrome via Modulating ALOX15

Objective. Acute coronary syndrome (ACS) is the most dangerous and deadly form of coronary heart disease. Herein, we aimed to explore ACS-specific circulating lncRNAs and their regulatory mechanisms. Methods. This study collected serum samples from ACS patients and healthy controls for microarray an...

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Veröffentlicht in:	Disease markers 2022, Vol.2022, p.8208471-24
Hauptverfasser:	Chen, Hao, Huang, Shiwei, Guan, Fanlu, Han, Sisi, Ye, Fanhao, Li, Xun, You, Liyi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute coronary syndromes Animal models Blood Cardiovascular disease Cardiovascular diseases Cholecystokinin Coronary artery Coronary artery disease Coronary vessels Damage Endothelial cells Enzymes Gene expression Genomes Heart attacks Heart diseases Heart failure High density lipoprotein Low density lipoprotein Medical imaging mRNA Myocardial infarction Non-coding RNA Patients Proteins Regulatory mechanisms (biology) siRNA Software Transcription factors Wound healing
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Beschreibung
Zusammenfassung:	Objective. Acute coronary syndrome (ACS) is the most dangerous and deadly form of coronary heart disease. Herein, we aimed to explore ACS-specific circulating lncRNAs and their regulatory mechanisms. Methods. This study collected serum samples from ACS patients and healthy controls for microarray analysis. Dysregulated circulating lncRNAs and mRNAs were determined with log2fold−change>1 and p
ISSN:	0278-0240 1875-8630
DOI:	10.1155/2022/8208471