UVB-Induced Secretion of IL-1β Promotes Melanogenesis by Upregulating TYR/TRP-1 Expression In Vitro

Purpose. Ultraviolet radiation (UVR) is one of the exogenous stimuli increasing melanogenesis. UV light, especially UVB, is also a potent inducer of epidermal cytokine release. This study is aimed at determining the underlying mechanisms by which UVB-induced cytokines in keratinocytes regulate melan...

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Veröffentlicht in:	BioMed research international 2022, Vol.2022 (1), p.8230646-8230646
Hauptverfasser:	Yang, Chun-Yan, Guo, Yanni, Wu, Wen-Juan, Man, Mao-Qiang, Tu, Ying, He, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal welfare Animals Antibiotics Cell growth Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Cytokines Dihydroxyphenylalanine Gene expression Hyperpigmentation IL-1β In vitro methods and tests Inflammation Interferon Type I Interleukin 1 Interleukin 10 Interleukin 17 Interleukin 6 Interleukin-1beta - metabolism Irradiation Keratinocytes Keratinocytes - metabolism Laboratory animals Levodopa Lysis Melanin Melanins Melanocytes Melanocytes - metabolism Melanoma Melanoma - metabolism Mice Mice, Inbred C57BL Microphthalmia-associated transcription factor Monophenol Monooxygenase - genetics Monophenol Monooxygenase - metabolism Oxidation Pregnancy Proteins Production methods Proteins Reagents RNA, Messenger - genetics siRNA Skin cancer Sodium hydroxide Stem Cell Factor Stem cells Tumor necrosis factor-α Tyrosinase Tyrosine Tyrosine - metabolism Ultraviolet radiation Ultraviolet Rays - adverse effects
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