Lipotoxicity as the Leading Cause of Non-Alcoholic Steatohepatitis
The emerging issues nowadays are non-alcoholic fatty liver disease (NAFLD) and its advanced stage non-alcoholic steatohepatitis (NASH), which further can be a predisposing factor for chronic liver complications, such as cirrhosis and/or development of hepatocellular carcinoma (HCC). Liver lipotoxici...
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| Veröffentlicht in: | International journal of molecular sciences 2022-05, Vol.23 (9), p.5146 |
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| container_title | International journal of molecular sciences |
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| creator | Branković, Marija Jovanović, Igor Dukić, Marija Radonjić, Tijana Oprić, Svetlana Klašnja, Slobodan Zdravković, Marija |
| description | The emerging issues nowadays are non-alcoholic fatty liver disease (NAFLD) and its advanced stage non-alcoholic steatohepatitis (NASH), which further can be a predisposing factor for chronic liver complications, such as cirrhosis and/or development of hepatocellular carcinoma (HCC). Liver lipotoxicity can influence the accumulation of reactive oxygen species (ROS), so oxidative stress is also crucial for the progression of NASH. Moreover, NASH is in strong connection with metabolic disorders, and supporting evidence shows that insulin resistance (IR) is in a close relation to NAFLD, as it is involved in the progression to NASH and further progression to hepatic fibrosis. The major issue is that, at the moment, NASH treatment is based on lifestyle changes only due to the fact that no approved therapeutic options are available. The development of new therapeutic strategies should be conducted towards the potential NAFLD and NASH treatment by the modulation of IR but also by dietary antioxidants. As it seems, NASH is going to be the leading indication for liver transplantation as a consequence of increased disease prevalence and the lack of approved treatment; thus, an effective solution is needed as soon as possible. |
| doi_str_mv | 10.3390/ijms23095146 |
| format | Article |
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Liver lipotoxicity can influence the accumulation of reactive oxygen species (ROS), so oxidative stress is also crucial for the progression of NASH. Moreover, NASH is in strong connection with metabolic disorders, and supporting evidence shows that insulin resistance (IR) is in a close relation to NAFLD, as it is involved in the progression to NASH and further progression to hepatic fibrosis. The major issue is that, at the moment, NASH treatment is based on lifestyle changes only due to the fact that no approved therapeutic options are available. The development of new therapeutic strategies should be conducted towards the potential NAFLD and NASH treatment by the modulation of IR but also by dietary antioxidants. 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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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Liver lipotoxicity can influence the accumulation of reactive oxygen species (ROS), so oxidative stress is also crucial for the progression of NASH. Moreover, NASH is in strong connection with metabolic disorders, and supporting evidence shows that insulin resistance (IR) is in a close relation to NAFLD, as it is involved in the progression to NASH and further progression to hepatic fibrosis. The major issue is that, at the moment, NASH treatment is based on lifestyle changes only due to the fact that no approved therapeutic options are available. The development of new therapeutic strategies should be conducted towards the potential NAFLD and NASH treatment by the modulation of IR but also by dietary antioxidants. As it seems, NASH is going to be the leading indication for liver transplantation as a consequence of increased disease prevalence and the lack of approved treatment; thus, an effective solution is needed as soon as possible.</description><subject>Abdomen</subject><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Autophagy</subject><subject>Body fat</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Cholesterol</subject><subject>Cirrhosis</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Disease</subject><subject>Disease Progression</subject><subject>Fatty acids</subject><subject>Fatty liver</subject><subject>Fibrosis</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Inflammation</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>Lipids</subject><subject>Liver</subject><subject>Liver - metabolism</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Branković, Marija</au><au>Jovanović, Igor</au><au>Dukić, Marija</au><au>Radonjić, Tijana</au><au>Oprić, Svetlana</au><au>Klašnja, Slobodan</au><au>Zdravković, Marija</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipotoxicity as the Leading Cause of Non-Alcoholic Steatohepatitis</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2022-05-05</date><risdate>2022</risdate><volume>23</volume><issue>9</issue><spage>5146</spage><pages>5146-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>The emerging issues nowadays are non-alcoholic fatty liver disease (NAFLD) and its advanced stage non-alcoholic steatohepatitis (NASH), which further can be a predisposing factor for chronic liver complications, such as cirrhosis and/or development of hepatocellular carcinoma (HCC). Liver lipotoxicity can influence the accumulation of reactive oxygen species (ROS), so oxidative stress is also crucial for the progression of NASH. Moreover, NASH is in strong connection with metabolic disorders, and supporting evidence shows that insulin resistance (IR) is in a close relation to NAFLD, as it is involved in the progression to NASH and further progression to hepatic fibrosis. The major issue is that, at the moment, NASH treatment is based on lifestyle changes only due to the fact that no approved therapeutic options are available. The development of new therapeutic strategies should be conducted towards the potential NAFLD and NASH treatment by the modulation of IR but also by dietary antioxidants. 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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Abdomen Antioxidants Apoptosis Autophagy Body fat Carcinoma, Hepatocellular - metabolism Cholesterol Cirrhosis Cytokines Diabetes Disease Disease Progression Fatty acids Fatty liver Fibrosis Hepatocellular carcinoma Humans Hypotheses Inflammation Insulin Insulin Resistance Lipids Liver Liver - metabolism Liver cancer Liver cirrhosis Liver Cirrhosis - pathology Liver diseases Liver Neoplasms - metabolism Metabolic disorders Metabolic syndrome Metabolites Non-alcoholic Fatty Liver Disease - metabolism Oxidative stress Pathogenesis Reactive oxygen species Review Transplantation Triglycerides Tumor necrosis factor-TNF Weight control |
| title | Lipotoxicity as the Leading Cause of Non-Alcoholic Steatohepatitis |
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