Nutritional Interventions in Pancreatic Cancer: A Systematic Review
(1) Background: Pancreatic cancer (PaCa) is directly related to malnutrition, cachexia and weight loss. Nutritional interventions (NI) are used in addition to standard therapy. The aim of this systematic review is to provide an overview of the types of NI and their effects. (2) Methods: We included...
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| Veröffentlicht in: | Cancers 2022-04, Vol.14 (9), p.2212 |
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| creator | Emanuel, Aline Krampitz, Julia Rosenberger, Friederike Kind, Sabine Rötzer, Ingeborg |
| description | (1) Background: Pancreatic cancer (PaCa) is directly related to malnutrition, cachexia and weight loss. Nutritional interventions (NI) are used in addition to standard therapy. The aim of this systematic review is to provide an overview of the types of NI and their effects. (2) Methods: We included RCTs with at least one intervention group receiving an NI and compared them with a control group with no NI, placebo or alternative treatment on cachexia, malnutrition or weight loss in patients with PaCa. Any available literature until 12 August 2021 was searched in the Pubmed and Cochrane databases. RCTs were sorted according to NI (parenteral nutrition, enteral nutrition, dietary supplements and mixed or special forms). (3) Results: Finally, 26 studies with a total of 2720 patients were included. The potential for bias was mostly moderate to high. Parenteral nutrition is associated with a higher incidence of complications. Enteral nutrition is associated with shorter length of stay in hospital, lower rate and development of complications, positive effects on cytokine rates and lower weight loss. Dietary supplements enriched with omega-3 fatty acids lead to higher body weight and lean body mass. (4) Conclusions: Enteral nutrition and dietary supplements with omega-3 fatty acids should be preferred in nutritional therapy of PaCa patients. |
| doi_str_mv | 10.3390/cancers14092212 |
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Nutritional interventions (NI) are used in addition to standard therapy. The aim of this systematic review is to provide an overview of the types of NI and their effects. (2) Methods: We included RCTs with at least one intervention group receiving an NI and compared them with a control group with no NI, placebo or alternative treatment on cachexia, malnutrition or weight loss in patients with PaCa. Any available literature until 12 August 2021 was searched in the Pubmed and Cochrane databases. RCTs were sorted according to NI (parenteral nutrition, enteral nutrition, dietary supplements and mixed or special forms). (3) Results: Finally, 26 studies with a total of 2720 patients were included. The potential for bias was mostly moderate to high. Parenteral nutrition is associated with a higher incidence of complications. Enteral nutrition is associated with shorter length of stay in hospital, lower rate and development of complications, positive effects on cytokine rates and lower weight loss. Dietary supplements enriched with omega-3 fatty acids lead to higher body weight and lean body mass. (4) Conclusions: Enteral nutrition and dietary supplements with omega-3 fatty acids should be preferred in nutritional therapy of PaCa patients.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers14092212</identifier><identifier>PMID: 35565341</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Anemia ; Anorexia ; Biochemistry ; Body mass ; Body mass index ; Body weight ; Body weight loss ; Cachexia ; Collaboration ; Counseling ; Cytokines ; Diet ; Dietary supplements ; Disease ; Enteral nutrition ; Fatty acids ; Immunology ; Intervention ; Lean body mass ; Length of stay ; Malnutrition ; Medical prognosis ; Mortality ; Muscle strength ; Nutrition research ; Nutrition therapy ; Nutritional status ; Pancreatic cancer ; Parenteral nutrition ; Patients ; Systematic Review</subject><ispartof>Cancers, 2022-04, Vol.14 (9), p.2212</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-8e0e8fc2ac0f3b0f5010973f34bc6c075fe5eb1d1a64f6de220807a101ee2e0e3</citedby><cites>FETCH-LOGICAL-c475t-8e0e8fc2ac0f3b0f5010973f34bc6c075fe5eb1d1a64f6de220807a101ee2e0e3</cites><orcidid>0000-0003-4928-4799 ; 0000-0002-4147-2958</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101959/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101959/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35565341$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Emanuel, Aline</creatorcontrib><creatorcontrib>Krampitz, Julia</creatorcontrib><creatorcontrib>Rosenberger, Friederike</creatorcontrib><creatorcontrib>Kind, Sabine</creatorcontrib><creatorcontrib>Rötzer, Ingeborg</creatorcontrib><title>Nutritional Interventions in Pancreatic Cancer: A Systematic Review</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>(1) Background: Pancreatic cancer (PaCa) is directly related to malnutrition, cachexia and weight loss. Nutritional interventions (NI) are used in addition to standard therapy. The aim of this systematic review is to provide an overview of the types of NI and their effects. (2) Methods: We included RCTs with at least one intervention group receiving an NI and compared them with a control group with no NI, placebo or alternative treatment on cachexia, malnutrition or weight loss in patients with PaCa. Any available literature until 12 August 2021 was searched in the Pubmed and Cochrane databases. RCTs were sorted according to NI (parenteral nutrition, enteral nutrition, dietary supplements and mixed or special forms). (3) Results: Finally, 26 studies with a total of 2720 patients were included. The potential for bias was mostly moderate to high. Parenteral nutrition is associated with a higher incidence of complications. Enteral nutrition is associated with shorter length of stay in hospital, lower rate and development of complications, positive effects on cytokine rates and lower weight loss. Dietary supplements enriched with omega-3 fatty acids lead to higher body weight and lean body mass. (4) Conclusions: Enteral nutrition and dietary supplements with omega-3 fatty acids should be preferred in nutritional therapy of PaCa patients.</description><subject>Anemia</subject><subject>Anorexia</subject><subject>Biochemistry</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body weight</subject><subject>Body weight loss</subject><subject>Cachexia</subject><subject>Collaboration</subject><subject>Counseling</subject><subject>Cytokines</subject><subject>Diet</subject><subject>Dietary supplements</subject><subject>Disease</subject><subject>Enteral nutrition</subject><subject>Fatty acids</subject><subject>Immunology</subject><subject>Intervention</subject><subject>Lean body mass</subject><subject>Length of stay</subject><subject>Malnutrition</subject><subject>Medical prognosis</subject><subject>Mortality</subject><subject>Muscle strength</subject><subject>Nutrition research</subject><subject>Nutrition therapy</subject><subject>Nutritional status</subject><subject>Pancreatic cancer</subject><subject>Parenteral nutrition</subject><subject>Patients</subject><subject>Systematic Review</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkUlPwzAQhS0EolXpmRuKxIVL6diOnYQDEqpYKlWAWM6W607AVZqAnRT13-MuVKW-jJdv3sz4EXJK4ZLzDPpGlwadpzFkjFF2QNoMEtaTMosPd_Yt0vV-CmFxThOZHJMWF0IKHtM2GTw2tbO1rUpdRMOyRjfHcnn0kS2j51DBoa6tiQarYlfRTfS68DXOVpcvOLf4c0KOcl147G5ih7zf3b4NHnqjp_vh4GbUM3Ei6l6KgGlumDaQ8zHkAihkCc95PDbSQCJyFDimE6plnMsJMgYpJJoCRWQhl3fI9Vr3qxnPcGJCo04X6svZmXYLVWmr_r-U9lN9VHOVBY1MZEHgYiPgqu8Gfa1m1hssCl1i1XjFpIxTgDThAT3fQ6dV48InrSiWCZnGLFD9NWVc5b3DfNsMBbX0SO15FDLOdmfY8n-O8F-5I46c</recordid><startdate>20220428</startdate><enddate>20220428</enddate><creator>Emanuel, Aline</creator><creator>Krampitz, Julia</creator><creator>Rosenberger, Friederike</creator><creator>Kind, Sabine</creator><creator>Rötzer, Ingeborg</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4928-4799</orcidid><orcidid>https://orcid.org/0000-0002-4147-2958</orcidid></search><sort><creationdate>20220428</creationdate><title>Nutritional Interventions in Pancreatic Cancer: A Systematic Review</title><author>Emanuel, Aline ; Krampitz, Julia ; Rosenberger, Friederike ; Kind, Sabine ; Rötzer, Ingeborg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-8e0e8fc2ac0f3b0f5010973f34bc6c075fe5eb1d1a64f6de220807a101ee2e0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anemia</topic><topic>Anorexia</topic><topic>Biochemistry</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body weight</topic><topic>Body weight loss</topic><topic>Cachexia</topic><topic>Collaboration</topic><topic>Counseling</topic><topic>Cytokines</topic><topic>Diet</topic><topic>Dietary supplements</topic><topic>Disease</topic><topic>Enteral nutrition</topic><topic>Fatty acids</topic><topic>Immunology</topic><topic>Intervention</topic><topic>Lean body mass</topic><topic>Length of stay</topic><topic>Malnutrition</topic><topic>Medical prognosis</topic><topic>Mortality</topic><topic>Muscle strength</topic><topic>Nutrition research</topic><topic>Nutrition therapy</topic><topic>Nutritional status</topic><topic>Pancreatic cancer</topic><topic>Parenteral nutrition</topic><topic>Patients</topic><topic>Systematic Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Emanuel, Aline</creatorcontrib><creatorcontrib>Krampitz, Julia</creatorcontrib><creatorcontrib>Rosenberger, Friederike</creatorcontrib><creatorcontrib>Kind, Sabine</creatorcontrib><creatorcontrib>Rötzer, Ingeborg</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Emanuel, Aline</au><au>Krampitz, Julia</au><au>Rosenberger, Friederike</au><au>Kind, Sabine</au><au>Rötzer, Ingeborg</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nutritional Interventions in Pancreatic Cancer: A Systematic Review</atitle><jtitle>Cancers</jtitle><addtitle>Cancers (Basel)</addtitle><date>2022-04-28</date><risdate>2022</risdate><volume>14</volume><issue>9</issue><spage>2212</spage><pages>2212-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>(1) Background: Pancreatic cancer (PaCa) is directly related to malnutrition, cachexia and weight loss. Nutritional interventions (NI) are used in addition to standard therapy. The aim of this systematic review is to provide an overview of the types of NI and their effects. (2) Methods: We included RCTs with at least one intervention group receiving an NI and compared them with a control group with no NI, placebo or alternative treatment on cachexia, malnutrition or weight loss in patients with PaCa. Any available literature until 12 August 2021 was searched in the Pubmed and Cochrane databases. RCTs were sorted according to NI (parenteral nutrition, enteral nutrition, dietary supplements and mixed or special forms). (3) Results: Finally, 26 studies with a total of 2720 patients were included. The potential for bias was mostly moderate to high. Parenteral nutrition is associated with a higher incidence of complications. Enteral nutrition is associated with shorter length of stay in hospital, lower rate and development of complications, positive effects on cytokine rates and lower weight loss. Dietary supplements enriched with omega-3 fatty acids lead to higher body weight and lean body mass. (4) Conclusions: Enteral nutrition and dietary supplements with omega-3 fatty acids should be preferred in nutritional therapy of PaCa patients.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35565341</pmid><doi>10.3390/cancers14092212</doi><orcidid>https://orcid.org/0000-0003-4928-4799</orcidid><orcidid>https://orcid.org/0000-0002-4147-2958</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Anemia Anorexia Biochemistry Body mass Body mass index Body weight Body weight loss Cachexia Collaboration Counseling Cytokines Diet Dietary supplements Disease Enteral nutrition Fatty acids Immunology Intervention Lean body mass Length of stay Malnutrition Medical prognosis Mortality Muscle strength Nutrition research Nutrition therapy Nutritional status Pancreatic cancer Parenteral nutrition Patients Systematic Review |
| title | Nutritional Interventions in Pancreatic Cancer: A Systematic Review |
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