Optical and Material Characteristics of MoS2/Cu2O Sensor for Detection of Lung Cancer Cell Types in Hydroplegia
In this study, n-type MoS2 monolayer flakes are grown through chemical vapor deposition (CVD), and a p-type Cu2O thin film is grown via electrochemical deposition. The crystal structure of the grown MoS2 flakes is analyzed through transmission electron microscopy. The monolayer structure of the MoS2...
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| Veröffentlicht in: | International journal of molecular sciences 2022-05, Vol.23 (9), p.4745 |
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| creator | Mukundan, Arvind Feng, Shih-Wei Weng, Yu-Hsin Tsao, Yu-Ming Artemkina, Sofya B. Fedorov, Vladimir E. Lin, Yen-Sheng Huang, Yu-Cheng Wang, Hsiang-Chen |
| description | In this study, n-type MoS2 monolayer flakes are grown through chemical vapor deposition (CVD), and a p-type Cu2O thin film is grown via electrochemical deposition. The crystal structure of the grown MoS2 flakes is analyzed through transmission electron microscopy. The monolayer structure of the MoS2 flakes is verified with Raman spectroscopy, multiphoton excitation microscopy, atomic force microscopy, and photoluminescence (PL) measurements. After the preliminary processing of the grown MoS2 flakes, the sample is then transferred onto a Cu2O thin film to complete a p-n heterogeneous structure. Data are confirmed via scanning electron microscopy, SHG, and Raman mapping measurements. The luminous energy gap between the two materials is examined through PL measurements. Results reveal that the thickness of the single-layer MoS2 film is 0.7 nm. PL mapping shows a micro signal generated at the 627 nm wavelength, which belongs to the B2 excitons of MoS2 and tends to increase gradually when it approaches 670 nm. Finally, the biosensor is used to detect lung cancer cell types in hydroplegia significantly reducing the current busy procedures and longer waiting time for detection. The results suggest that the fabricated sensor is highly sensitive to the change in the photocurrent with the number of each cell, the linear regression of the three cell types is as high as 99%. By measuring the slope of the photocurrent, we can identify the type of cells and the number of cells. |
| doi_str_mv | 10.3390/ijms23094745 |
| format | Article |
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The crystal structure of the grown MoS2 flakes is analyzed through transmission electron microscopy. The monolayer structure of the MoS2 flakes is verified with Raman spectroscopy, multiphoton excitation microscopy, atomic force microscopy, and photoluminescence (PL) measurements. After the preliminary processing of the grown MoS2 flakes, the sample is then transferred onto a Cu2O thin film to complete a p-n heterogeneous structure. Data are confirmed via scanning electron microscopy, SHG, and Raman mapping measurements. The luminous energy gap between the two materials is examined through PL measurements. Results reveal that the thickness of the single-layer MoS2 film is 0.7 nm. PL mapping shows a micro signal generated at the 627 nm wavelength, which belongs to the B2 excitons of MoS2 and tends to increase gradually when it approaches 670 nm. Finally, the biosensor is used to detect lung cancer cell types in hydroplegia significantly reducing the current busy procedures and longer waiting time for detection. The results suggest that the fabricated sensor is highly sensitive to the change in the photocurrent with the number of each cell, the linear regression of the three cell types is as high as 99%. By measuring the slope of the photocurrent, we can identify the type of cells and the number of cells.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms23094745</identifier><identifier>PMID: 35563136</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Atomic force microscopy ; Biosensors ; Caustic soda ; Chemical vapor deposition ; Copper oxides ; Crystal growth ; Crystal structure ; Electrodes ; Electrolytes ; Electron microscopy ; Energy ; Excitation spectra ; Excitons ; Flakes ; Glass substrates ; Graphene ; Graphite ; Heterogeneous structure ; Lung cancer ; Mapping ; Measurement techniques ; Microscopy ; Molybdenum ; Monolayers ; Nanoparticles ; Photoelectric effect ; Photoelectric emission ; Photoluminescence ; Photons ; Plating ; Raman spectroscopy ; Scanning electron microscopy ; Sensors ; Sodium ; Solid lubricants ; Solvents ; Thickness ; Thin films ; Transmission electron microscopy</subject><ispartof>International journal of molecular sciences, 2022-05, Vol.23 (9), p.4745</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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Finally, the biosensor is used to detect lung cancer cell types in hydroplegia significantly reducing the current busy procedures and longer waiting time for detection. The results suggest that the fabricated sensor is highly sensitive to the change in the photocurrent with the number of each cell, the linear regression of the three cell types is as high as 99%. 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The crystal structure of the grown MoS2 flakes is analyzed through transmission electron microscopy. The monolayer structure of the MoS2 flakes is verified with Raman spectroscopy, multiphoton excitation microscopy, atomic force microscopy, and photoluminescence (PL) measurements. After the preliminary processing of the grown MoS2 flakes, the sample is then transferred onto a Cu2O thin film to complete a p-n heterogeneous structure. Data are confirmed via scanning electron microscopy, SHG, and Raman mapping measurements. The luminous energy gap between the two materials is examined through PL measurements. Results reveal that the thickness of the single-layer MoS2 film is 0.7 nm. PL mapping shows a micro signal generated at the 627 nm wavelength, which belongs to the B2 excitons of MoS2 and tends to increase gradually when it approaches 670 nm. Finally, the biosensor is used to detect lung cancer cell types in hydroplegia significantly reducing the current busy procedures and longer waiting time for detection. The results suggest that the fabricated sensor is highly sensitive to the change in the photocurrent with the number of each cell, the linear regression of the three cell types is as high as 99%. By measuring the slope of the photocurrent, we can identify the type of cells and the number of cells.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>35563136</pmid><doi>10.3390/ijms23094745</doi><orcidid>https://orcid.org/0000-0002-7741-3722</orcidid><orcidid>https://orcid.org/0000-0003-4107-2062</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Atomic force microscopy Biosensors Caustic soda Chemical vapor deposition Copper oxides Crystal growth Crystal structure Electrodes Electrolytes Electron microscopy Energy Excitation spectra Excitons Flakes Glass substrates Graphene Graphite Heterogeneous structure Lung cancer Mapping Measurement techniques Microscopy Molybdenum Monolayers Nanoparticles Photoelectric effect Photoelectric emission Photoluminescence Photons Plating Raman spectroscopy Scanning electron microscopy Sensors Sodium Solid lubricants Solvents Thickness Thin films Transmission electron microscopy |
| title | Optical and Material Characteristics of MoS2/Cu2O Sensor for Detection of Lung Cancer Cell Types in Hydroplegia |
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