Development and Characterization of PEGylated Fatty Acid- Block -Poly(ε-caprolactone) Novel Block Copolymers and Their Self-Assembled Nanostructures for Ocular Delivery of Cyclosporine A

Low aqueous solubility and membrane permeability of some drugs are considered major limitations for their use in clinical practice. Polymeric micelles are one of the potential nano-drug delivery systems that were found to ameliorate the low aqueous solubility of hydrophobic drugs. The main objective...

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Veröffentlicht in:	Polymers 2022-04, Vol.14 (9), p.1635
Hauptverfasser:	Binkhathlan, Ziyad, Alomrani, Abdullah H, Hoxha, Olsi, Ali, Raisuddin, Kalam, Mohd Abul, Alshamsan, Aws
Format:	Artikel
Sprache:	eng
Schlagworte:	Block copolymers Bulk polymerization Chemical synthesis Chromatography Copolymers Drug delivery systems Ethylene glycol Fatty acids Image transmission In vivo methods and tests Irritation Micelles Molecular weight NMR Nuclear magnetic resonance Particle size Pharmaceutical industry Photon correlation spectroscopy Polycaprolactone Polydispersity Polyethylene glycol Polymerization Polymers Potassium Ring opening Self-assembly Software Solubility Spectrum analysis Sustained release Transplants & implants
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