Intraligand Excited States Turn a Ruthenium Oligothiophene Complex into a Light-Triggered Ubertoxin with Anticancer Effects in Extreme Hypoxia

Ru­(II) complexes that undergo photosubstitution reactions from triplet metal-centered (3MC) excited states are of interest in photochemotherapy (PCT) due to their potential to produce cytotoxic effects in hypoxia. Dual-action systems that incorporate this stoichiometric mode to complement the oxyge...

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Veröffentlicht in:	Journal of the American Chemical Society 2022-05, Vol.144 (18), p.8317-8336
Hauptverfasser:	Roque III, John A., Cole, Houston D., Barrett, Patrick C., Lifshits, Liubov M., Hodges, Rachel O., Kim, Susy, Deep, Gagan, Francés-Monerris, Antonio, Alberto, Marta E., Cameron, Colin G., McFarland, Sherri A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Humans Hypoxia Phenanthrolines Photochemotherapy Photosensitizing Agents - pharmacology Ruthenium - pharmacology
Online-Zugang:	Volltext
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