HIV‐induced neuroinflammation inhibits oligodendrocyte maturation via glutamate‐dependent activation of the PERK arm of the integrated stress response

Despite combined antiretroviral therapy (cART), HIV‐associated neurocognitive disorder (HAND) affects 30–50% of HIV‐positive patients. Importantly, persistent white matter pathologies, specifically corpus callosum thinning and disruption of white matter microstructures observed in patients with HAND...

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Veröffentlicht in:	Glia 2021-09, Vol.69 (9), p.2252-2271
Hauptverfasser:	Roth, Lindsay M., Akay‐Espinoza, Cagla, Grinspan, Judith B., Jordan‐Sciutto, Kelly L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiretroviral agents Antiretroviral therapy Cell Differentiation Cells, Cultured Cognition Cognitive ability Corpus callosum Glial stem cells glutamate Glutamic Acid - metabolism Glutamic acid receptors Glutamic acid receptors (ionotropic) Hand HIV HIV Infections - pathology Human immunodeficiency virus Humans Infections Inflammation integrated stress response Kainic acid Macrophages Maturation Monocytes myelin neuroinflammation Neuroinflammatory Diseases Oligodendrocyte Precursor Cells - metabolism oligodendrocytes Oligodendroglia - metabolism Patients PERK Rats Receptors Signal transduction Signaling Substantia alba α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
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