Imaging Mass Spectrometry Reveals Alterations in N-Linked Glycosylation That Are Associated With Histopathological Changes in Nonalcoholic Steatohepatitis in Mouse and Human

Nonalcoholic steatohepatitis (NASH) is the progressive form of nonalcoholic fatty liver disease (NAFLD) and is characterized by inflammation, hepatocyte injury, and fibrosis. Further, NASH is a risk factor for cirrhosis and hepatocellular carcinoma. Previous research demonstrated that serum N-glycan...

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Veröffentlicht in:	Molecular & cellular proteomics 2022-05, Vol.21 (5), p.100225, Article 100225
Hauptverfasser:	Ochoa-Rios, Shaaron, O'Connor, Ian P., Kent, Lindsey N., Clouse, Julian M., Hadjiyannis, Yannis, Koivisto, Christopher, Pecot, Thierry, Angel, Peggi M., Drake, Richard R., Leone, Gustavo, Mehta, Anand S., Rockey, Don C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diet, Western Disease Models, Animal fibrosis fucosylation Glycosylation Humans Inflammation - metabolism Liver - metabolism Liver Cirrhosis - genetics Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver Neoplasms - metabolism Mass Spectrometry Mice N-glycosylation NAFLD NASH Non-alcoholic Fatty Liver Disease - metabolism steatosis
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