GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases

Colorectal cancer (CRC) remains the third cause of cancer-related mortality in Western countries, metastases are the main cause of death. CRC treatment remains limited by systemic toxicity and chemotherapy resistance. Therefore, nanoparticle-mediated delivery of cytotoxic agents selectively to cance...

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Veröffentlicht in:	Drug delivery 2022-12, Vol.29 (1), p.1384-1397
Hauptverfasser:	Sala, Rita, Rioja-Blanco, Elisa, Serna, Naroa, Sánchez-García, Laura, Álamo, Patricia, Alba-Castellón, Lorena, Casanova, Isolda, López-Pousa, Antonio, Unzueta, Ugutz, Céspedes, María Virtudes, Vázquez, Esther, Villaverde, Antonio, Mangues, Ramon
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis Colorectal cancer Colorectal Neoplasms - drug therapy CXCR4 Cytotoxicity Drug Delivery Systems GSDMD Humans Metastasis Nanoparticles Neoplasm Metastasis - prevention & control PE24 exotoxin Phosphate-Binding Proteins - metabolism Pore Forming Cytotoxic Proteins - metabolism Pyroptosis Receptors, CXCR4 - metabolism Receptors, CXCR4 - therapeutic use Signal Transduction Stem cells targeted nanoparticle
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