Effect of C-Reactive Protein-to-Albumin Ratio on Prognosis in Gastric Cancer Patients
The ratio of c-reactive protein-to-albumin (CRP/Alb) is a biochemical marker of systemic inflammatory response and has been associated with poor survival in cancer. The purpose of this study was to investigate the effect of CRP/Alb ratios on prognosis in gastric cancers. This study included a retros...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2022-04, Vol.14 (4), p.e23972-e23972 |
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| creator | Alkurt, Ertugrul G Durak, Dogukan Turhan, Veysel Barış Sahiner, Ibrahim Tayfun |
| description | The ratio of c-reactive protein-to-albumin (CRP/Alb) is a biochemical marker of systemic inflammatory response and has been associated with poor survival in cancer. The purpose of this study was to investigate the effect of CRP/Alb ratios on prognosis in gastric cancers.
This study included a retrospective review of a total of 147 patients with locally advanced gastric cancer. Mean platelet volume (MPV) was analyzed statistically to find a prognostic relationship between monocyte/lymphocyte ratio, platelet distribution volume (PDW), MPV/platelet, c-reactive protein/albumin ratio (CAR), and gastric cancer. Patients were staged according to the American Joint Cancer Committee (AJCC) Staging Guidelines.
The CRP/Alb ratio was independently associated with overall survival (OS) in patients with gastric cancer (GC). The CAR was above 0.25 in 52.7% (77) of the patients and below 0.25 in 47.3% (69) of the patients. Patients under 0.25 had statistically longer survival rates.
A high preoperative CAR value could predict poor prognosis in locally advanced gastric patients. The same predictive value was not observed in other hematological parameters. This simple and cost-effective ratio can be used as a clinically accessible biomarker to assist clinicians in determining future treatment plans. |
| doi_str_mv | 10.7759/cureus.23972 |
| format | Article |
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This study included a retrospective review of a total of 147 patients with locally advanced gastric cancer. Mean platelet volume (MPV) was analyzed statistically to find a prognostic relationship between monocyte/lymphocyte ratio, platelet distribution volume (PDW), MPV/platelet, c-reactive protein/albumin ratio (CAR), and gastric cancer. Patients were staged according to the American Joint Cancer Committee (AJCC) Staging Guidelines.
The CRP/Alb ratio was independently associated with overall survival (OS) in patients with gastric cancer (GC). The CAR was above 0.25 in 52.7% (77) of the patients and below 0.25 in 47.3% (69) of the patients. Patients under 0.25 had statistically longer survival rates.
A high preoperative CAR value could predict poor prognosis in locally advanced gastric patients. The same predictive value was not observed in other hematological parameters. This simple and cost-effective ratio can be used as a clinically accessible biomarker to assist clinicians in determining future treatment plans.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.23972</identifier><identifier>PMID: 35547460</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Antigens ; Biomarkers ; Blood platelets ; Colorectal cancer ; Cytokines ; Gastric cancer ; Gastroenterology ; General Surgery ; Hematology ; Lymphatic system ; Lymphocytes ; Medical prognosis ; Oncology ; Ovarian cancer ; Patients ; Proteins ; Surgery ; Survival analysis ; Tumors</subject><ispartof>Curēus (Palo Alto, CA), 2022-04, Vol.14 (4), p.e23972-e23972</ispartof><rights>Copyright © 2022, Alkurt et al.</rights><rights>Copyright © 2022, Alkurt et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2022, Alkurt et al. 2022 Alkurt et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-38121c500ac3b0b1d7c65513343d4c5eeafcca6348a5472d87cb930cf5f5a54e3</citedby><cites>FETCH-LOGICAL-c342t-38121c500ac3b0b1d7c65513343d4c5eeafcca6348a5472d87cb930cf5f5a54e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090126/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090126/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35547460$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alkurt, Ertugrul G</creatorcontrib><creatorcontrib>Durak, Dogukan</creatorcontrib><creatorcontrib>Turhan, Veysel Barış</creatorcontrib><creatorcontrib>Sahiner, Ibrahim Tayfun</creatorcontrib><title>Effect of C-Reactive Protein-to-Albumin Ratio on Prognosis in Gastric Cancer Patients</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>The ratio of c-reactive protein-to-albumin (CRP/Alb) is a biochemical marker of systemic inflammatory response and has been associated with poor survival in cancer. The purpose of this study was to investigate the effect of CRP/Alb ratios on prognosis in gastric cancers.
This study included a retrospective review of a total of 147 patients with locally advanced gastric cancer. Mean platelet volume (MPV) was analyzed statistically to find a prognostic relationship between monocyte/lymphocyte ratio, platelet distribution volume (PDW), MPV/platelet, c-reactive protein/albumin ratio (CAR), and gastric cancer. Patients were staged according to the American Joint Cancer Committee (AJCC) Staging Guidelines.
The CRP/Alb ratio was independently associated with overall survival (OS) in patients with gastric cancer (GC). The CAR was above 0.25 in 52.7% (77) of the patients and below 0.25 in 47.3% (69) of the patients. Patients under 0.25 had statistically longer survival rates.
A high preoperative CAR value could predict poor prognosis in locally advanced gastric patients. The same predictive value was not observed in other hematological parameters. This simple and cost-effective ratio can be used as a clinically accessible biomarker to assist clinicians in determining future treatment plans.</description><subject>Antigens</subject><subject>Biomarkers</subject><subject>Blood platelets</subject><subject>Colorectal cancer</subject><subject>Cytokines</subject><subject>Gastric cancer</subject><subject>Gastroenterology</subject><subject>General Surgery</subject><subject>Hematology</subject><subject>Lymphatic system</subject><subject>Lymphocytes</subject><subject>Medical prognosis</subject><subject>Oncology</subject><subject>Ovarian cancer</subject><subject>Patients</subject><subject>Proteins</subject><subject>Surgery</subject><subject>Survival analysis</subject><subject>Tumors</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkc1LxDAQxYMoKurNsxS8eLCa77QXQRa_QHARPYd0NtVIN9EkXfC_N-uqqKcZZn68ecNDaJ_gE6VEewpjtGM6oaxVdA1tUyKbuiENX__Vb6G9lF4wxgQrihXeRFtMCK64xNvo8aLvLeQq9NWkvrcGslvYahpDts7XOdTnQzfOna_uTXahCn65e_IhuVSV6ZVJOTqoJsaDjdW0QNbntIs2ejMku_dVd9Dj5cXD5Lq-vbu6mZzf1sA4zTVrCCUgMDbAOtyRmQIpBGGMsxkHYa3pAYxkvDHFL501CrqWYehFL8rEsh10ttJ9Hbu5nUG5Hc2gX6Obm_iug3H678a7Z_0UFrrFLSZUFoGjL4EY3kabsp67BHYYjLdhTJpKyVXLKaMFPfyHvoQx-vJeoRRppGRYFOp4RUEMKUXb_5ghWC8j06vI9GdkBT_4_cAP_B0Q-wCJ8JLY</recordid><startdate>20220409</startdate><enddate>20220409</enddate><creator>Alkurt, Ertugrul G</creator><creator>Durak, Dogukan</creator><creator>Turhan, Veysel Barış</creator><creator>Sahiner, Ibrahim Tayfun</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220409</creationdate><title>Effect of C-Reactive Protein-to-Albumin Ratio on Prognosis in Gastric Cancer Patients</title><author>Alkurt, Ertugrul G ; Durak, Dogukan ; Turhan, Veysel Barış ; Sahiner, Ibrahim Tayfun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-38121c500ac3b0b1d7c65513343d4c5eeafcca6348a5472d87cb930cf5f5a54e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antigens</topic><topic>Biomarkers</topic><topic>Blood platelets</topic><topic>Colorectal cancer</topic><topic>Cytokines</topic><topic>Gastric cancer</topic><topic>Gastroenterology</topic><topic>General Surgery</topic><topic>Hematology</topic><topic>Lymphatic system</topic><topic>Lymphocytes</topic><topic>Medical prognosis</topic><topic>Oncology</topic><topic>Ovarian cancer</topic><topic>Patients</topic><topic>Proteins</topic><topic>Surgery</topic><topic>Survival analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alkurt, Ertugrul G</creatorcontrib><creatorcontrib>Durak, Dogukan</creatorcontrib><creatorcontrib>Turhan, Veysel Barış</creatorcontrib><creatorcontrib>Sahiner, Ibrahim Tayfun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alkurt, Ertugrul G</au><au>Durak, Dogukan</au><au>Turhan, Veysel Barış</au><au>Sahiner, Ibrahim Tayfun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of C-Reactive Protein-to-Albumin Ratio on Prognosis in Gastric Cancer Patients</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2022-04-09</date><risdate>2022</risdate><volume>14</volume><issue>4</issue><spage>e23972</spage><epage>e23972</epage><pages>e23972-e23972</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>The ratio of c-reactive protein-to-albumin (CRP/Alb) is a biochemical marker of systemic inflammatory response and has been associated with poor survival in cancer. The purpose of this study was to investigate the effect of CRP/Alb ratios on prognosis in gastric cancers.
This study included a retrospective review of a total of 147 patients with locally advanced gastric cancer. Mean platelet volume (MPV) was analyzed statistically to find a prognostic relationship between monocyte/lymphocyte ratio, platelet distribution volume (PDW), MPV/platelet, c-reactive protein/albumin ratio (CAR), and gastric cancer. Patients were staged according to the American Joint Cancer Committee (AJCC) Staging Guidelines.
The CRP/Alb ratio was independently associated with overall survival (OS) in patients with gastric cancer (GC). The CAR was above 0.25 in 52.7% (77) of the patients and below 0.25 in 47.3% (69) of the patients. Patients under 0.25 had statistically longer survival rates.
A high preoperative CAR value could predict poor prognosis in locally advanced gastric patients. The same predictive value was not observed in other hematological parameters. This simple and cost-effective ratio can be used as a clinically accessible biomarker to assist clinicians in determining future treatment plans.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>35547460</pmid><doi>10.7759/cureus.23972</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Antigens Biomarkers Blood platelets Colorectal cancer Cytokines Gastric cancer Gastroenterology General Surgery Hematology Lymphatic system Lymphocytes Medical prognosis Oncology Ovarian cancer Patients Proteins Surgery Survival analysis Tumors |
| title | Effect of C-Reactive Protein-to-Albumin Ratio on Prognosis in Gastric Cancer Patients |
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