A pandemic center’s experience of managing pregnant women with COVID‐19 infection in Turkey: A prospective cohort study
Objective To evaluate the course and effect of coronavirus disease 2019 (COVID‐19) on pregnant women followed up in a Turkish institution. Methods A prospective, single tertiary pandemic center cohort study was conducted on pregnant women with confirmed or suspected severe acute respiratory syndrome...
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| Veröffentlicht in: | International journal of gynecology and obstetrics 2020-10, Vol.151 (1), p.74-82 |
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| creator | Sahin, Dilek Tanacan, Atakan Erol, Seyit A. Anuk, Ali T. Eyi, Elif G.Y. Ozgu‐ Erdinc, A. Seval Yucel, Aykan Keskin, Huseyin L. Tayman, Cüneyt Unlu, Serpil Kirca, Fisun Dinc, Bedia San, Ishak Parpucu, Ü. Murat Surel, Aziz A. Moraloglu, Ozlem T. |
| description | Objective
To evaluate the course and effect of coronavirus disease 2019 (COVID‐19) on pregnant women followed up in a Turkish institution.
Methods
A prospective, single tertiary pandemic center cohort study was conducted on pregnant women with confirmed or suspected severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. Positive diagnosis was made on a real‐time polymerase chain reaction (RT‐PCR) assay of a nasopharyngeal and oropharyngeal specimen. Demographic features, clinical characteristics, and maternal and perinatal outcomes were evaluated.
Results
SARS‐CoV‐2 was suspected in 100 pregnant women. Of them, 29 had the diagnosis confirmed by RT‐PCR. Eight of the remaining 71 cases had clinical findings highly suspicious for COVID‐19. Ten (34.5%) of the confirmed cases had co‐morbidities. Cough (58.6%) and myalgia (51.7%) were the leading symptoms. COVID‐19 therapy was given to 10 (34.5%) patients. There were no admissions to the intensive care unit. Pregnancy complications were present in 7 (24.1%) patients. Half of the births (5/10) were cesarean deliveries. None of the neonates were positive for SARS‐CoV‐2. Samples of breastmilk were also negative for the virus. Three neonates were admitted to the neonatal intensive care unit.
Conclusion
The clinical course of COVID 19 during pregnancy appears to be mild in the present study.
RT‐PCR positivity and clinical findings should be considered when managing COVID‐19 during pregnancy. Cases managed by a multidisciplinary team are associated with favorable outcomes. |
| doi_str_mv | 10.1002/ijgo.13318 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9087688</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2424990822</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4208-42ca9abe37610ade96aef299b3f998ee7f091b6c3e997fadde307058f49fe82e3</originalsourceid><addsrcrecordid>eNp9kc1u1DAURi0EokNhwwMgLxFSin9CbLNAqgZaBlWaTWFreZzrjEtiBzvpMGLTR-i2r9cnaYYpFWxY-Urf0bm--hB6SckRJYS99RdNPKKcU_kIzagUquClUI_RbApJIZhiB-hZzheEECoofYoOOKsk4yWboV_HuDehhs5bbCEMkG6vbjKGnz0kD8ECjg53JpjGhwb3CZpgwoA3sYOAN35Y4_ny2-Lj7dU1VdgHB3bwMUwTPh_Td9i-x9OCFHO_Cy4B27iOacB5GOvtc_TEmTbDi_v3EH09-XQ-_1ycLU8X8-OzwpaMyKJk1iizAi4qSkwNqjLgmFIr7pSSAMIRRVeV5aCUcKaugRNB3klXKgeSAT9EH_beflx1UO_OTKbVffKdSVsdjdf_JsGvdRMvtSJSVFJOgtf3ghR_jJAH3flsoW1NgDhmzUpWqglmbELf7FE7HZ0TuIc1lOhdW3rXlv7d1gS_-vtjD-ifeiaA7oGNb2H7H5VefDld7qV3w6mknA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2424990822</pqid></control><display><type>article</type><title>A pandemic center’s experience of managing pregnant women with COVID‐19 infection in Turkey: A prospective cohort study</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Sahin, Dilek ; Tanacan, Atakan ; Erol, Seyit A. ; Anuk, Ali T. ; Eyi, Elif G.Y. ; Ozgu‐ Erdinc, A. Seval ; Yucel, Aykan ; Keskin, Huseyin L. ; Tayman, Cüneyt ; Unlu, Serpil ; Kirca, Fisun ; Dinc, Bedia ; San, Ishak ; Parpucu, Ü. Murat ; Surel, Aziz A. ; Moraloglu, Ozlem T.</creator><creatorcontrib>Sahin, Dilek ; Tanacan, Atakan ; Erol, Seyit A. ; Anuk, Ali T. ; Eyi, Elif G.Y. ; Ozgu‐ Erdinc, A. Seval ; Yucel, Aykan ; Keskin, Huseyin L. ; Tayman, Cüneyt ; Unlu, Serpil ; Kirca, Fisun ; Dinc, Bedia ; San, Ishak ; Parpucu, Ü. Murat ; Surel, Aziz A. ; Moraloglu, Ozlem T.</creatorcontrib><description>Objective
To evaluate the course and effect of coronavirus disease 2019 (COVID‐19) on pregnant women followed up in a Turkish institution.
Methods
A prospective, single tertiary pandemic center cohort study was conducted on pregnant women with confirmed or suspected severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. Positive diagnosis was made on a real‐time polymerase chain reaction (RT‐PCR) assay of a nasopharyngeal and oropharyngeal specimen. Demographic features, clinical characteristics, and maternal and perinatal outcomes were evaluated.
Results
SARS‐CoV‐2 was suspected in 100 pregnant women. Of them, 29 had the diagnosis confirmed by RT‐PCR. Eight of the remaining 71 cases had clinical findings highly suspicious for COVID‐19. Ten (34.5%) of the confirmed cases had co‐morbidities. Cough (58.6%) and myalgia (51.7%) were the leading symptoms. COVID‐19 therapy was given to 10 (34.5%) patients. There were no admissions to the intensive care unit. Pregnancy complications were present in 7 (24.1%) patients. Half of the births (5/10) were cesarean deliveries. None of the neonates were positive for SARS‐CoV‐2. Samples of breastmilk were also negative for the virus. Three neonates were admitted to the neonatal intensive care unit.
Conclusion
The clinical course of COVID 19 during pregnancy appears to be mild in the present study.
RT‐PCR positivity and clinical findings should be considered when managing COVID‐19 during pregnancy. Cases managed by a multidisciplinary team are associated with favorable outcomes.</description><identifier>ISSN: 0020-7292</identifier><identifier>ISSN: 1879-3479</identifier><identifier>EISSN: 1879-3479</identifier><identifier>DOI: 10.1002/ijgo.13318</identifier><identifier>PMID: 32682342</identifier><language>eng</language><publisher>United States: John Wiley and Sons Inc</publisher><subject>Adult ; Cesarean Section ; Clinical ; Cohort Studies ; COVID-19 - complications ; COVID-19 - diagnosis ; COVID-19 - therapy ; COVID‐19 ; Female ; Humans ; Infant, Newborn ; Maternal outcome ; Neonatal outcomes ; Obstetric outcomes ; Pandemics - statistics & numerical data ; Pregnancy ; Pregnancy Complications, Infectious - diagnosis ; Pregnancy Complications, Infectious - therapy ; Prospective Studies ; SARS-CoV-2 - isolation & purification ; SARS‐CoV‐2 ; Turkey</subject><ispartof>International journal of gynecology and obstetrics, 2020-10, Vol.151 (1), p.74-82</ispartof><rights>2020 International Federation of Gynecology and Obstetrics</rights><rights>2020 International Federation of Gynecology and Obstetrics.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4208-42ca9abe37610ade96aef299b3f998ee7f091b6c3e997fadde307058f49fe82e3</citedby><cites>FETCH-LOGICAL-c4208-42ca9abe37610ade96aef299b3f998ee7f091b6c3e997fadde307058f49fe82e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijgo.13318$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijgo.13318$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32682342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sahin, Dilek</creatorcontrib><creatorcontrib>Tanacan, Atakan</creatorcontrib><creatorcontrib>Erol, Seyit A.</creatorcontrib><creatorcontrib>Anuk, Ali T.</creatorcontrib><creatorcontrib>Eyi, Elif G.Y.</creatorcontrib><creatorcontrib>Ozgu‐ Erdinc, A. Seval</creatorcontrib><creatorcontrib>Yucel, Aykan</creatorcontrib><creatorcontrib>Keskin, Huseyin L.</creatorcontrib><creatorcontrib>Tayman, Cüneyt</creatorcontrib><creatorcontrib>Unlu, Serpil</creatorcontrib><creatorcontrib>Kirca, Fisun</creatorcontrib><creatorcontrib>Dinc, Bedia</creatorcontrib><creatorcontrib>San, Ishak</creatorcontrib><creatorcontrib>Parpucu, Ü. Murat</creatorcontrib><creatorcontrib>Surel, Aziz A.</creatorcontrib><creatorcontrib>Moraloglu, Ozlem T.</creatorcontrib><title>A pandemic center’s experience of managing pregnant women with COVID‐19 infection in Turkey: A prospective cohort study</title><title>International journal of gynecology and obstetrics</title><addtitle>Int J Gynaecol Obstet</addtitle><description>Objective
To evaluate the course and effect of coronavirus disease 2019 (COVID‐19) on pregnant women followed up in a Turkish institution.
Methods
A prospective, single tertiary pandemic center cohort study was conducted on pregnant women with confirmed or suspected severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. Positive diagnosis was made on a real‐time polymerase chain reaction (RT‐PCR) assay of a nasopharyngeal and oropharyngeal specimen. Demographic features, clinical characteristics, and maternal and perinatal outcomes were evaluated.
Results
SARS‐CoV‐2 was suspected in 100 pregnant women. Of them, 29 had the diagnosis confirmed by RT‐PCR. Eight of the remaining 71 cases had clinical findings highly suspicious for COVID‐19. Ten (34.5%) of the confirmed cases had co‐morbidities. Cough (58.6%) and myalgia (51.7%) were the leading symptoms. COVID‐19 therapy was given to 10 (34.5%) patients. There were no admissions to the intensive care unit. Pregnancy complications were present in 7 (24.1%) patients. Half of the births (5/10) were cesarean deliveries. None of the neonates were positive for SARS‐CoV‐2. Samples of breastmilk were also negative for the virus. Three neonates were admitted to the neonatal intensive care unit.
Conclusion
The clinical course of COVID 19 during pregnancy appears to be mild in the present study.
RT‐PCR positivity and clinical findings should be considered when managing COVID‐19 during pregnancy. Cases managed by a multidisciplinary team are associated with favorable outcomes.</description><subject>Adult</subject><subject>Cesarean Section</subject><subject>Clinical</subject><subject>Cohort Studies</subject><subject>COVID-19 - complications</subject><subject>COVID-19 - diagnosis</subject><subject>COVID-19 - therapy</subject><subject>COVID‐19</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Maternal outcome</subject><subject>Neonatal outcomes</subject><subject>Obstetric outcomes</subject><subject>Pandemics - statistics & numerical data</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - diagnosis</subject><subject>Pregnancy Complications, Infectious - therapy</subject><subject>Prospective Studies</subject><subject>SARS-CoV-2 - isolation & purification</subject><subject>SARS‐CoV‐2</subject><subject>Turkey</subject><issn>0020-7292</issn><issn>1879-3479</issn><issn>1879-3479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAURi0EokNhwwMgLxFSin9CbLNAqgZaBlWaTWFreZzrjEtiBzvpMGLTR-i2r9cnaYYpFWxY-Urf0bm--hB6SckRJYS99RdNPKKcU_kIzagUquClUI_RbApJIZhiB-hZzheEECoofYoOOKsk4yWboV_HuDehhs5bbCEMkG6vbjKGnz0kD8ECjg53JpjGhwb3CZpgwoA3sYOAN35Y4_ny2-Lj7dU1VdgHB3bwMUwTPh_Td9i-x9OCFHO_Cy4B27iOacB5GOvtc_TEmTbDi_v3EH09-XQ-_1ycLU8X8-OzwpaMyKJk1iizAi4qSkwNqjLgmFIr7pSSAMIRRVeV5aCUcKaugRNB3klXKgeSAT9EH_beflx1UO_OTKbVffKdSVsdjdf_JsGvdRMvtSJSVFJOgtf3ghR_jJAH3flsoW1NgDhmzUpWqglmbELf7FE7HZ0TuIc1lOhdW3rXlv7d1gS_-vtjD-ifeiaA7oGNb2H7H5VefDld7qV3w6mknA</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Sahin, Dilek</creator><creator>Tanacan, Atakan</creator><creator>Erol, Seyit A.</creator><creator>Anuk, Ali T.</creator><creator>Eyi, Elif G.Y.</creator><creator>Ozgu‐ Erdinc, A. Seval</creator><creator>Yucel, Aykan</creator><creator>Keskin, Huseyin L.</creator><creator>Tayman, Cüneyt</creator><creator>Unlu, Serpil</creator><creator>Kirca, Fisun</creator><creator>Dinc, Bedia</creator><creator>San, Ishak</creator><creator>Parpucu, Ü. Murat</creator><creator>Surel, Aziz A.</creator><creator>Moraloglu, Ozlem T.</creator><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202010</creationdate><title>A pandemic center’s experience of managing pregnant women with COVID‐19 infection in Turkey: A prospective cohort study</title><author>Sahin, Dilek ; Tanacan, Atakan ; Erol, Seyit A. ; Anuk, Ali T. ; Eyi, Elif G.Y. ; Ozgu‐ Erdinc, A. Seval ; Yucel, Aykan ; Keskin, Huseyin L. ; Tayman, Cüneyt ; Unlu, Serpil ; Kirca, Fisun ; Dinc, Bedia ; San, Ishak ; Parpucu, Ü. Murat ; Surel, Aziz A. ; Moraloglu, Ozlem T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4208-42ca9abe37610ade96aef299b3f998ee7f091b6c3e997fadde307058f49fe82e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Cesarean Section</topic><topic>Clinical</topic><topic>Cohort Studies</topic><topic>COVID-19 - complications</topic><topic>COVID-19 - diagnosis</topic><topic>COVID-19 - therapy</topic><topic>COVID‐19</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Maternal outcome</topic><topic>Neonatal outcomes</topic><topic>Obstetric outcomes</topic><topic>Pandemics - statistics & numerical data</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - diagnosis</topic><topic>Pregnancy Complications, Infectious - therapy</topic><topic>Prospective Studies</topic><topic>SARS-CoV-2 - isolation & purification</topic><topic>SARS‐CoV‐2</topic><topic>Turkey</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sahin, Dilek</creatorcontrib><creatorcontrib>Tanacan, Atakan</creatorcontrib><creatorcontrib>Erol, Seyit A.</creatorcontrib><creatorcontrib>Anuk, Ali T.</creatorcontrib><creatorcontrib>Eyi, Elif G.Y.</creatorcontrib><creatorcontrib>Ozgu‐ Erdinc, A. Seval</creatorcontrib><creatorcontrib>Yucel, Aykan</creatorcontrib><creatorcontrib>Keskin, Huseyin L.</creatorcontrib><creatorcontrib>Tayman, Cüneyt</creatorcontrib><creatorcontrib>Unlu, Serpil</creatorcontrib><creatorcontrib>Kirca, Fisun</creatorcontrib><creatorcontrib>Dinc, Bedia</creatorcontrib><creatorcontrib>San, Ishak</creatorcontrib><creatorcontrib>Parpucu, Ü. Murat</creatorcontrib><creatorcontrib>Surel, Aziz A.</creatorcontrib><creatorcontrib>Moraloglu, Ozlem T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sahin, Dilek</au><au>Tanacan, Atakan</au><au>Erol, Seyit A.</au><au>Anuk, Ali T.</au><au>Eyi, Elif G.Y.</au><au>Ozgu‐ Erdinc, A. Seval</au><au>Yucel, Aykan</au><au>Keskin, Huseyin L.</au><au>Tayman, Cüneyt</au><au>Unlu, Serpil</au><au>Kirca, Fisun</au><au>Dinc, Bedia</au><au>San, Ishak</au><au>Parpucu, Ü. Murat</au><au>Surel, Aziz A.</au><au>Moraloglu, Ozlem T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A pandemic center’s experience of managing pregnant women with COVID‐19 infection in Turkey: A prospective cohort study</atitle><jtitle>International journal of gynecology and obstetrics</jtitle><addtitle>Int J Gynaecol Obstet</addtitle><date>2020-10</date><risdate>2020</risdate><volume>151</volume><issue>1</issue><spage>74</spage><epage>82</epage><pages>74-82</pages><issn>0020-7292</issn><issn>1879-3479</issn><eissn>1879-3479</eissn><abstract>Objective
To evaluate the course and effect of coronavirus disease 2019 (COVID‐19) on pregnant women followed up in a Turkish institution.
Methods
A prospective, single tertiary pandemic center cohort study was conducted on pregnant women with confirmed or suspected severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. Positive diagnosis was made on a real‐time polymerase chain reaction (RT‐PCR) assay of a nasopharyngeal and oropharyngeal specimen. Demographic features, clinical characteristics, and maternal and perinatal outcomes were evaluated.
Results
SARS‐CoV‐2 was suspected in 100 pregnant women. Of them, 29 had the diagnosis confirmed by RT‐PCR. Eight of the remaining 71 cases had clinical findings highly suspicious for COVID‐19. Ten (34.5%) of the confirmed cases had co‐morbidities. Cough (58.6%) and myalgia (51.7%) were the leading symptoms. COVID‐19 therapy was given to 10 (34.5%) patients. There were no admissions to the intensive care unit. Pregnancy complications were present in 7 (24.1%) patients. Half of the births (5/10) were cesarean deliveries. None of the neonates were positive for SARS‐CoV‐2. Samples of breastmilk were also negative for the virus. Three neonates were admitted to the neonatal intensive care unit.
Conclusion
The clinical course of COVID 19 during pregnancy appears to be mild in the present study.
RT‐PCR positivity and clinical findings should be considered when managing COVID‐19 during pregnancy. Cases managed by a multidisciplinary team are associated with favorable outcomes.</abstract><cop>United States</cop><pub>John Wiley and Sons Inc</pub><pmid>32682342</pmid><doi>10.1002/ijgo.13318</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0020-7292 |
| ispartof | International journal of gynecology and obstetrics, 2020-10, Vol.151 (1), p.74-82 |
| issn | 0020-7292 1879-3479 1879-3479 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult Cesarean Section Clinical Cohort Studies COVID-19 - complications COVID-19 - diagnosis COVID-19 - therapy COVID‐19 Female Humans Infant, Newborn Maternal outcome Neonatal outcomes Obstetric outcomes Pandemics - statistics & numerical data Pregnancy Pregnancy Complications, Infectious - diagnosis Pregnancy Complications, Infectious - therapy Prospective Studies SARS-CoV-2 - isolation & purification SARS‐CoV‐2 Turkey |
| title | A pandemic center’s experience of managing pregnant women with COVID‐19 infection in Turkey: A prospective cohort study |
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