Maternal characteristics and pregnancy outcomes of hospitalized pregnant women with SARS‐CoV‐2 infection in South Africa: An International Network of Obstetric Survey Systems‐based cohort study
Objective To describe risk factors and outcomes of pregnant women infected with SARS‐CoV‐2 admitted to South African healthcare facilities. Methods A population‐based cohort study was conducted utilizing an amended International Obstetric Surveillance System protocol. Data on pregnant women with SAR...
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| Veröffentlicht in: | International journal of gynecology and obstetrics 2021-12, Vol.155 (3), p.455-465 |
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| creator | Budhram, Samantha Vannevel, Valerie Botha, Tanita Chauke, Lawrence Bhoora, Shastra Balie, Gaynor M. Odell, Natalie Lombaard, Hennie Wise, Amy Georgiou, Chrysanthi Ngxola, Nondumiso Wynne, Emma Mbewu, Unati Mabenge, Mfundo Phinzi, Sibusiso Gubu‐Ntaba, Nontsikelelo Goldman, Gareth Tunkyi, Kay Prithipal, Sudhir Naidoo, Keshree Venkatachalam, Santhi Moodley, Terence Mould, Sean Hlabisa, Mzuvele Govender, Logie Maistry, Charlene Habineza, John P. Israel, Priya Foolchand, Serantha Tsibiyane, Nomandla V. Panday, Mala Soma‐Pillay, Priya Adam, Sumaiya Molokoane, Felicia Mojela, Matthew S. Rensburg, Elizabeth J. Mashamba, Tshililo Matjila, Mushi Fawcus, Sue Osman, Ayesha Venter, Mareli Petro, Gregory Fakier, Ahminah Langenegger, Eduard Cluver, Catherine A. Bekker, Adrie Waard, Liesl Stewart, Chantal Ngene, Nnabuike C. Lunda, Ongombe N.Cebekhulu, Sylvia Moodley, Siva Koranteng‐Peprah, Mama‐Asu Ati, Emmanuel M. C. Maswime, Salome Yates, Laura M. |
| description | Objective
To describe risk factors and outcomes of pregnant women infected with SARS‐CoV‐2 admitted to South African healthcare facilities.
Methods
A population‐based cohort study was conducted utilizing an amended International Obstetric Surveillance System protocol. Data on pregnant women with SARS‐CoV‐2 infection, hospitalized between April 14, 2020, and November 24, 2020, were analyzed.
Results
A total of 36 hospitals submitted data on 673 infected hospitalized pregnant women; 217 (32.2%) were admitted for COVID‐19 illness and 456 for other indications. There were 39 deaths with a case fatality rate of 6.3%: 32 (14.7%) deaths occurred in women admitted for COVID‐19 illness compared to 7 (1.8%) in women admitted for other indications. Of the women, 106 (15.9%) required critical care. Maternal tuberculosis, but not HIV co‐infection or other co‐morbidities, was associated with admission for COVID‐19 illness. Rates of cesarean delivery did not differ significantly between women admitted for COVID‐19 and those admitted for other indications. There were 179 (35.4%) preterm births, 25 (4.7%) stillbirths, 12 (2.3%) neonatal deaths, and 162 (30.8%) neonatal admissions. Neonatal outcomes did not differ significantly from those of infected women admitted for other indications.
Conclusion
The maternal mortality rate was high among women admitted with SARS‐CoV‐2 infection and higher in women admitted primarily for COVID‐19 illness with tuberculosis being the only co‐morbidity associated with admission.
Synopsis
A multicenter, observational study describing the risk factors and pregnancy outcomes of women admitted with SARS‐CoV‐2 infection in South Africa, a low‐ and middle‐income country. |
| doi_str_mv | 10.1002/ijgo.13917 |
| format | Article |
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To describe risk factors and outcomes of pregnant women infected with SARS‐CoV‐2 admitted to South African healthcare facilities.
Methods
A population‐based cohort study was conducted utilizing an amended International Obstetric Surveillance System protocol. Data on pregnant women with SARS‐CoV‐2 infection, hospitalized between April 14, 2020, and November 24, 2020, were analyzed.
Results
A total of 36 hospitals submitted data on 673 infected hospitalized pregnant women; 217 (32.2%) were admitted for COVID‐19 illness and 456 for other indications. There were 39 deaths with a case fatality rate of 6.3%: 32 (14.7%) deaths occurred in women admitted for COVID‐19 illness compared to 7 (1.8%) in women admitted for other indications. Of the women, 106 (15.9%) required critical care. Maternal tuberculosis, but not HIV co‐infection or other co‐morbidities, was associated with admission for COVID‐19 illness. Rates of cesarean delivery did not differ significantly between women admitted for COVID‐19 and those admitted for other indications. There were 179 (35.4%) preterm births, 25 (4.7%) stillbirths, 12 (2.3%) neonatal deaths, and 162 (30.8%) neonatal admissions. Neonatal outcomes did not differ significantly from those of infected women admitted for other indications.
Conclusion
The maternal mortality rate was high among women admitted with SARS‐CoV‐2 infection and higher in women admitted primarily for COVID‐19 illness with tuberculosis being the only co‐morbidity associated with admission.
Synopsis
A multicenter, observational study describing the risk factors and pregnancy outcomes of women admitted with SARS‐CoV‐2 infection in South Africa, a low‐ and middle‐income country.</description><identifier>ISSN: 0020-7292</identifier><identifier>EISSN: 1879-3479</identifier><identifier>DOI: 10.1002/ijgo.13917</identifier><identifier>PMID: 34499750</identifier><language>eng</language><publisher>United States: John Wiley and Sons Inc</publisher><subject>Clinical ; Cohort Studies ; COVID-19 ; Female ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; low‐ and middle‐income country ; perinatal ; Pregnancy ; Pregnancy Complications, Infectious - epidemiology ; Pregnancy Outcome - epidemiology ; Pregnant Women ; Premature Birth ; SARS-CoV-2 ; South Africa - epidemiology</subject><ispartof>International journal of gynecology and obstetrics, 2021-12, Vol.155 (3), p.455-465</ispartof><rights>2021 International Federation of Gynecology and Obstetrics.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4207-c4a32ac4672926de62661cba49ba05649af79aed87c3479ba329e43fbf09e1c3</citedby><cites>FETCH-LOGICAL-c4207-c4a32ac4672926de62661cba49ba05649af79aed87c3479ba329e43fbf09e1c3</cites><orcidid>0000-0002-5747-1714</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijgo.13917$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijgo.13917$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34499750$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Budhram, Samantha</creatorcontrib><creatorcontrib>Vannevel, Valerie</creatorcontrib><creatorcontrib>Botha, Tanita</creatorcontrib><creatorcontrib>Chauke, Lawrence</creatorcontrib><creatorcontrib>Bhoora, Shastra</creatorcontrib><creatorcontrib>Balie, Gaynor M.</creatorcontrib><creatorcontrib>Odell, Natalie</creatorcontrib><creatorcontrib>Lombaard, Hennie</creatorcontrib><creatorcontrib>Wise, Amy</creatorcontrib><creatorcontrib>Georgiou, Chrysanthi</creatorcontrib><creatorcontrib>Ngxola, Nondumiso</creatorcontrib><creatorcontrib>Wynne, Emma</creatorcontrib><creatorcontrib>Mbewu, Unati</creatorcontrib><creatorcontrib>Mabenge, Mfundo</creatorcontrib><creatorcontrib>Phinzi, Sibusiso</creatorcontrib><creatorcontrib>Gubu‐Ntaba, Nontsikelelo</creatorcontrib><creatorcontrib>Goldman, Gareth</creatorcontrib><creatorcontrib>Tunkyi, Kay</creatorcontrib><creatorcontrib>Prithipal, Sudhir</creatorcontrib><creatorcontrib>Naidoo, Keshree</creatorcontrib><creatorcontrib>Venkatachalam, Santhi</creatorcontrib><creatorcontrib>Moodley, Terence</creatorcontrib><creatorcontrib>Mould, Sean</creatorcontrib><creatorcontrib>Hlabisa, Mzuvele</creatorcontrib><creatorcontrib>Govender, Logie</creatorcontrib><creatorcontrib>Maistry, Charlene</creatorcontrib><creatorcontrib>Habineza, John P.</creatorcontrib><creatorcontrib>Israel, Priya</creatorcontrib><creatorcontrib>Foolchand, Serantha</creatorcontrib><creatorcontrib>Tsibiyane, Nomandla V.</creatorcontrib><creatorcontrib>Panday, Mala</creatorcontrib><creatorcontrib>Soma‐Pillay, Priya</creatorcontrib><creatorcontrib>Adam, Sumaiya</creatorcontrib><creatorcontrib>Molokoane, Felicia</creatorcontrib><creatorcontrib>Mojela, Matthew S.</creatorcontrib><creatorcontrib>Rensburg, Elizabeth J.</creatorcontrib><creatorcontrib>Mashamba, Tshililo</creatorcontrib><creatorcontrib>Matjila, Mushi</creatorcontrib><creatorcontrib>Fawcus, Sue</creatorcontrib><creatorcontrib>Osman, Ayesha</creatorcontrib><creatorcontrib>Venter, Mareli</creatorcontrib><creatorcontrib>Petro, Gregory</creatorcontrib><creatorcontrib>Fakier, Ahminah</creatorcontrib><creatorcontrib>Langenegger, Eduard</creatorcontrib><creatorcontrib>Cluver, Catherine A.</creatorcontrib><creatorcontrib>Bekker, Adrie</creatorcontrib><creatorcontrib>Waard, Liesl</creatorcontrib><creatorcontrib>Stewart, Chantal</creatorcontrib><creatorcontrib>Ngene, Nnabuike C.</creatorcontrib><creatorcontrib>Lunda, Ongombe</creatorcontrib><creatorcontrib>N.Cebekhulu, Sylvia</creatorcontrib><creatorcontrib>Moodley, Siva</creatorcontrib><creatorcontrib>Koranteng‐Peprah, Mama‐Asu</creatorcontrib><creatorcontrib>Ati, Emmanuel M. C.</creatorcontrib><creatorcontrib>Maswime, Salome</creatorcontrib><creatorcontrib>Yates, Laura M.</creatorcontrib><title>Maternal characteristics and pregnancy outcomes of hospitalized pregnant women with SARS‐CoV‐2 infection in South Africa: An International Network of Obstetric Survey Systems‐based cohort study</title><title>International journal of gynecology and obstetrics</title><addtitle>Int J Gynaecol Obstet</addtitle><description>Objective
To describe risk factors and outcomes of pregnant women infected with SARS‐CoV‐2 admitted to South African healthcare facilities.
Methods
A population‐based cohort study was conducted utilizing an amended International Obstetric Surveillance System protocol. Data on pregnant women with SARS‐CoV‐2 infection, hospitalized between April 14, 2020, and November 24, 2020, were analyzed.
Results
A total of 36 hospitals submitted data on 673 infected hospitalized pregnant women; 217 (32.2%) were admitted for COVID‐19 illness and 456 for other indications. There were 39 deaths with a case fatality rate of 6.3%: 32 (14.7%) deaths occurred in women admitted for COVID‐19 illness compared to 7 (1.8%) in women admitted for other indications. Of the women, 106 (15.9%) required critical care. Maternal tuberculosis, but not HIV co‐infection or other co‐morbidities, was associated with admission for COVID‐19 illness. Rates of cesarean delivery did not differ significantly between women admitted for COVID‐19 and those admitted for other indications. There were 179 (35.4%) preterm births, 25 (4.7%) stillbirths, 12 (2.3%) neonatal deaths, and 162 (30.8%) neonatal admissions. Neonatal outcomes did not differ significantly from those of infected women admitted for other indications.
Conclusion
The maternal mortality rate was high among women admitted with SARS‐CoV‐2 infection and higher in women admitted primarily for COVID‐19 illness with tuberculosis being the only co‐morbidity associated with admission.
Synopsis
A multicenter, observational study describing the risk factors and pregnancy outcomes of women admitted with SARS‐CoV‐2 infection in South Africa, a low‐ and middle‐income country.</description><subject>Clinical</subject><subject>Cohort Studies</subject><subject>COVID-19</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infectious Disease Transmission, Vertical</subject><subject>low‐ and middle‐income country</subject><subject>perinatal</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - epidemiology</subject><subject>Pregnancy Outcome - epidemiology</subject><subject>Pregnant Women</subject><subject>Premature Birth</subject><subject>SARS-CoV-2</subject><subject>South Africa - epidemiology</subject><issn>0020-7292</issn><issn>1879-3479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS0EotPChgdAXiKkKXaSiWMWSKMRlEGFkUjF1nKcm4lLYg-201G64hF4K96DJ8HplBFs2Fz_nE_nXt2D0DNKzikhySt9vbXnNOWUPUAzWjA-TzPGH6JZFMmcJTw5QafeXxNCKKP0MTpJs4xztiAz9POjDOCM7LBqpZMqPrQPWnksTY13DrZGGjViOwRle_DYNri1fqeD7PQtHJGA91E2eK9Di8vl5_LX9x8r-yXWBGvTgAramnjDZXRq8bJxWsnXeGnw2twNMOlxik8Q9tZ9ndpsKh8gRA6Xg7uBEZdj_Oh99Kykj62Vba0L2IehHp-gR43sPDy9P8_Q1bu3V6v388vNxXq1vJyrLCEsVpkmUmX5tJW8hjzJc6oqmfFKkkWecdkwLqEumJp2WEWaQ5Y2VUM4UJWeoTcH291Q9VArMMHJTuyc7qUbhZVa_KsY3YqtvRGcFCxf8Gjw4t7A2W8D-CB67RV0nTRgBy-SBaM8KYqkiOjLA6qc9d5Bc2xDiZiCF1Pw4i74CD__e7Aj-ifpCNADsNcdjP-xEusPF5uD6W_1EcJx</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Budhram, Samantha</creator><creator>Vannevel, Valerie</creator><creator>Botha, Tanita</creator><creator>Chauke, Lawrence</creator><creator>Bhoora, Shastra</creator><creator>Balie, Gaynor M.</creator><creator>Odell, Natalie</creator><creator>Lombaard, Hennie</creator><creator>Wise, Amy</creator><creator>Georgiou, Chrysanthi</creator><creator>Ngxola, Nondumiso</creator><creator>Wynne, Emma</creator><creator>Mbewu, Unati</creator><creator>Mabenge, Mfundo</creator><creator>Phinzi, Sibusiso</creator><creator>Gubu‐Ntaba, Nontsikelelo</creator><creator>Goldman, Gareth</creator><creator>Tunkyi, Kay</creator><creator>Prithipal, Sudhir</creator><creator>Naidoo, Keshree</creator><creator>Venkatachalam, Santhi</creator><creator>Moodley, Terence</creator><creator>Mould, Sean</creator><creator>Hlabisa, Mzuvele</creator><creator>Govender, Logie</creator><creator>Maistry, Charlene</creator><creator>Habineza, John P.</creator><creator>Israel, Priya</creator><creator>Foolchand, Serantha</creator><creator>Tsibiyane, Nomandla V.</creator><creator>Panday, Mala</creator><creator>Soma‐Pillay, Priya</creator><creator>Adam, Sumaiya</creator><creator>Molokoane, Felicia</creator><creator>Mojela, Matthew S.</creator><creator>Rensburg, Elizabeth J.</creator><creator>Mashamba, Tshililo</creator><creator>Matjila, Mushi</creator><creator>Fawcus, Sue</creator><creator>Osman, Ayesha</creator><creator>Venter, Mareli</creator><creator>Petro, Gregory</creator><creator>Fakier, Ahminah</creator><creator>Langenegger, Eduard</creator><creator>Cluver, Catherine A.</creator><creator>Bekker, Adrie</creator><creator>Waard, Liesl</creator><creator>Stewart, Chantal</creator><creator>Ngene, Nnabuike C.</creator><creator>Lunda, Ongombe</creator><creator>N.Cebekhulu, Sylvia</creator><creator>Moodley, Siva</creator><creator>Koranteng‐Peprah, Mama‐Asu</creator><creator>Ati, Emmanuel M. C.</creator><creator>Maswime, Salome</creator><creator>Yates, Laura M.</creator><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5747-1714</orcidid></search><sort><creationdate>202112</creationdate><title>Maternal characteristics and pregnancy outcomes of hospitalized pregnant women with SARS‐CoV‐2 infection in South Africa: An International Network of Obstetric Survey Systems‐based cohort study</title><author>Budhram, Samantha ; Vannevel, Valerie ; Botha, Tanita ; Chauke, Lawrence ; Bhoora, Shastra ; Balie, Gaynor M. ; Odell, Natalie ; Lombaard, Hennie ; Wise, Amy ; Georgiou, Chrysanthi ; Ngxola, Nondumiso ; Wynne, Emma ; Mbewu, Unati ; Mabenge, Mfundo ; Phinzi, Sibusiso ; Gubu‐Ntaba, Nontsikelelo ; Goldman, Gareth ; Tunkyi, Kay ; Prithipal, Sudhir ; Naidoo, Keshree ; Venkatachalam, Santhi ; Moodley, Terence ; Mould, Sean ; Hlabisa, Mzuvele ; Govender, Logie ; Maistry, Charlene ; Habineza, John P. ; Israel, Priya ; Foolchand, Serantha ; Tsibiyane, Nomandla V. ; Panday, Mala ; Soma‐Pillay, Priya ; Adam, Sumaiya ; Molokoane, Felicia ; Mojela, Matthew S. ; Rensburg, Elizabeth J. ; Mashamba, Tshililo ; Matjila, Mushi ; Fawcus, Sue ; Osman, Ayesha ; Venter, Mareli ; Petro, Gregory ; Fakier, Ahminah ; Langenegger, Eduard ; Cluver, Catherine A. ; Bekker, Adrie ; Waard, Liesl ; Stewart, Chantal ; Ngene, Nnabuike C. ; Lunda, Ongombe ; N.Cebekhulu, Sylvia ; Moodley, Siva ; Koranteng‐Peprah, Mama‐Asu ; Ati, Emmanuel M. C. ; Maswime, Salome ; Yates, Laura M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4207-c4a32ac4672926de62661cba49ba05649af79aed87c3479ba329e43fbf09e1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Clinical</topic><topic>Cohort Studies</topic><topic>COVID-19</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infectious Disease Transmission, Vertical</topic><topic>low‐ and middle‐income country</topic><topic>perinatal</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - epidemiology</topic><topic>Pregnancy Outcome - epidemiology</topic><topic>Pregnant Women</topic><topic>Premature Birth</topic><topic>SARS-CoV-2</topic><topic>South Africa - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Budhram, Samantha</creatorcontrib><creatorcontrib>Vannevel, Valerie</creatorcontrib><creatorcontrib>Botha, Tanita</creatorcontrib><creatorcontrib>Chauke, Lawrence</creatorcontrib><creatorcontrib>Bhoora, Shastra</creatorcontrib><creatorcontrib>Balie, Gaynor M.</creatorcontrib><creatorcontrib>Odell, Natalie</creatorcontrib><creatorcontrib>Lombaard, Hennie</creatorcontrib><creatorcontrib>Wise, Amy</creatorcontrib><creatorcontrib>Georgiou, Chrysanthi</creatorcontrib><creatorcontrib>Ngxola, Nondumiso</creatorcontrib><creatorcontrib>Wynne, Emma</creatorcontrib><creatorcontrib>Mbewu, Unati</creatorcontrib><creatorcontrib>Mabenge, Mfundo</creatorcontrib><creatorcontrib>Phinzi, Sibusiso</creatorcontrib><creatorcontrib>Gubu‐Ntaba, Nontsikelelo</creatorcontrib><creatorcontrib>Goldman, Gareth</creatorcontrib><creatorcontrib>Tunkyi, Kay</creatorcontrib><creatorcontrib>Prithipal, Sudhir</creatorcontrib><creatorcontrib>Naidoo, Keshree</creatorcontrib><creatorcontrib>Venkatachalam, Santhi</creatorcontrib><creatorcontrib>Moodley, Terence</creatorcontrib><creatorcontrib>Mould, Sean</creatorcontrib><creatorcontrib>Hlabisa, Mzuvele</creatorcontrib><creatorcontrib>Govender, Logie</creatorcontrib><creatorcontrib>Maistry, Charlene</creatorcontrib><creatorcontrib>Habineza, John P.</creatorcontrib><creatorcontrib>Israel, Priya</creatorcontrib><creatorcontrib>Foolchand, Serantha</creatorcontrib><creatorcontrib>Tsibiyane, Nomandla V.</creatorcontrib><creatorcontrib>Panday, Mala</creatorcontrib><creatorcontrib>Soma‐Pillay, Priya</creatorcontrib><creatorcontrib>Adam, Sumaiya</creatorcontrib><creatorcontrib>Molokoane, Felicia</creatorcontrib><creatorcontrib>Mojela, Matthew S.</creatorcontrib><creatorcontrib>Rensburg, Elizabeth J.</creatorcontrib><creatorcontrib>Mashamba, Tshililo</creatorcontrib><creatorcontrib>Matjila, Mushi</creatorcontrib><creatorcontrib>Fawcus, Sue</creatorcontrib><creatorcontrib>Osman, Ayesha</creatorcontrib><creatorcontrib>Venter, Mareli</creatorcontrib><creatorcontrib>Petro, Gregory</creatorcontrib><creatorcontrib>Fakier, Ahminah</creatorcontrib><creatorcontrib>Langenegger, Eduard</creatorcontrib><creatorcontrib>Cluver, Catherine A.</creatorcontrib><creatorcontrib>Bekker, Adrie</creatorcontrib><creatorcontrib>Waard, Liesl</creatorcontrib><creatorcontrib>Stewart, Chantal</creatorcontrib><creatorcontrib>Ngene, Nnabuike C.</creatorcontrib><creatorcontrib>Lunda, Ongombe</creatorcontrib><creatorcontrib>N.Cebekhulu, Sylvia</creatorcontrib><creatorcontrib>Moodley, Siva</creatorcontrib><creatorcontrib>Koranteng‐Peprah, Mama‐Asu</creatorcontrib><creatorcontrib>Ati, Emmanuel M. C.</creatorcontrib><creatorcontrib>Maswime, Salome</creatorcontrib><creatorcontrib>Yates, Laura M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Budhram, Samantha</au><au>Vannevel, Valerie</au><au>Botha, Tanita</au><au>Chauke, Lawrence</au><au>Bhoora, Shastra</au><au>Balie, Gaynor M.</au><au>Odell, Natalie</au><au>Lombaard, Hennie</au><au>Wise, Amy</au><au>Georgiou, Chrysanthi</au><au>Ngxola, Nondumiso</au><au>Wynne, Emma</au><au>Mbewu, Unati</au><au>Mabenge, Mfundo</au><au>Phinzi, Sibusiso</au><au>Gubu‐Ntaba, Nontsikelelo</au><au>Goldman, Gareth</au><au>Tunkyi, Kay</au><au>Prithipal, Sudhir</au><au>Naidoo, Keshree</au><au>Venkatachalam, Santhi</au><au>Moodley, Terence</au><au>Mould, Sean</au><au>Hlabisa, Mzuvele</au><au>Govender, Logie</au><au>Maistry, Charlene</au><au>Habineza, John P.</au><au>Israel, Priya</au><au>Foolchand, Serantha</au><au>Tsibiyane, Nomandla V.</au><au>Panday, Mala</au><au>Soma‐Pillay, Priya</au><au>Adam, Sumaiya</au><au>Molokoane, Felicia</au><au>Mojela, Matthew S.</au><au>Rensburg, Elizabeth J.</au><au>Mashamba, Tshililo</au><au>Matjila, Mushi</au><au>Fawcus, Sue</au><au>Osman, Ayesha</au><au>Venter, Mareli</au><au>Petro, Gregory</au><au>Fakier, Ahminah</au><au>Langenegger, Eduard</au><au>Cluver, Catherine A.</au><au>Bekker, Adrie</au><au>Waard, Liesl</au><au>Stewart, Chantal</au><au>Ngene, Nnabuike C.</au><au>Lunda, Ongombe</au><au>N.Cebekhulu, Sylvia</au><au>Moodley, Siva</au><au>Koranteng‐Peprah, Mama‐Asu</au><au>Ati, Emmanuel M. C.</au><au>Maswime, Salome</au><au>Yates, Laura M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal characteristics and pregnancy outcomes of hospitalized pregnant women with SARS‐CoV‐2 infection in South Africa: An International Network of Obstetric Survey Systems‐based cohort study</atitle><jtitle>International journal of gynecology and obstetrics</jtitle><addtitle>Int J Gynaecol Obstet</addtitle><date>2021-12</date><risdate>2021</risdate><volume>155</volume><issue>3</issue><spage>455</spage><epage>465</epage><pages>455-465</pages><issn>0020-7292</issn><eissn>1879-3479</eissn><abstract>Objective
To describe risk factors and outcomes of pregnant women infected with SARS‐CoV‐2 admitted to South African healthcare facilities.
Methods
A population‐based cohort study was conducted utilizing an amended International Obstetric Surveillance System protocol. Data on pregnant women with SARS‐CoV‐2 infection, hospitalized between April 14, 2020, and November 24, 2020, were analyzed.
Results
A total of 36 hospitals submitted data on 673 infected hospitalized pregnant women; 217 (32.2%) were admitted for COVID‐19 illness and 456 for other indications. There were 39 deaths with a case fatality rate of 6.3%: 32 (14.7%) deaths occurred in women admitted for COVID‐19 illness compared to 7 (1.8%) in women admitted for other indications. Of the women, 106 (15.9%) required critical care. Maternal tuberculosis, but not HIV co‐infection or other co‐morbidities, was associated with admission for COVID‐19 illness. Rates of cesarean delivery did not differ significantly between women admitted for COVID‐19 and those admitted for other indications. There were 179 (35.4%) preterm births, 25 (4.7%) stillbirths, 12 (2.3%) neonatal deaths, and 162 (30.8%) neonatal admissions. Neonatal outcomes did not differ significantly from those of infected women admitted for other indications.
Conclusion
The maternal mortality rate was high among women admitted with SARS‐CoV‐2 infection and higher in women admitted primarily for COVID‐19 illness with tuberculosis being the only co‐morbidity associated with admission.
Synopsis
A multicenter, observational study describing the risk factors and pregnancy outcomes of women admitted with SARS‐CoV‐2 infection in South Africa, a low‐ and middle‐income country.</abstract><cop>United States</cop><pub>John Wiley and Sons Inc</pub><pmid>34499750</pmid><doi>10.1002/ijgo.13917</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-5747-1714</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-7292 |
| ispartof | International journal of gynecology and obstetrics, 2021-12, Vol.155 (3), p.455-465 |
| issn | 0020-7292 1879-3479 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9087659 |
| source | MEDLINE; Wiley Journals |
| subjects | Clinical Cohort Studies COVID-19 Female Humans Infant, Newborn Infectious Disease Transmission, Vertical low‐ and middle‐income country perinatal Pregnancy Pregnancy Complications, Infectious - epidemiology Pregnancy Outcome - epidemiology Pregnant Women Premature Birth SARS-CoV-2 South Africa - epidemiology |
| title | Maternal characteristics and pregnancy outcomes of hospitalized pregnant women with SARS‐CoV‐2 infection in South Africa: An International Network of Obstetric Survey Systems‐based cohort study |
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