A new sensitive UPLC-MS/MS method for the determination of cucurbitacin B in rat plasma: application to an absolute bioavailability study

Cucurbitacin B (CuB) is a highly oxygenated tetracyclic triterpene, and a Biopharmaceutics Classification System (BCS) class IV drug used for the treatment of persistent hepatitis, chronic hepatitis, and primary liver cancer. Nevertheless, CuB has low solubility and low permeability, and is present...

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Veröffentlicht in:	RSC advances 2018-01, Vol.8 (54), p.30978-30985
Hauptverfasser:	Xiao, Ya, Zhao, Qiang, Wu, Qian, Chang, Jinhua, Xue, Hefei, Liu, Cuizhe, Liu, Xigang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetonitrile Bioavailability Chemistry chronic hepatitis drug formulations drugs estrone Ethyl acetate Flow velocity Formic acid Hepatitis humans Ionization Ions Linearity Liquid chromatography liquid-liquid extraction Liver liver neoplasms Low concentrations Mass spectrometry monitoring permeability pharmacokinetics Pharmacology Rats solubility tandem mass spectrometry triterpenoids ultra-performance liquid chromatography
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