Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model

Streptococcus pneumoniae is the primary cause of community-acquired bacterial pneumonia with rates of penicillin and multidrug-resistance exceeding 80% and 40%, respectively. The innate immune response generates a variety of antimicrobial agents to control infection, including zinc stress. Here, we...

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Veröffentlicht in:	Cell reports (Cambridge) 2022-01, Vol.38 (2), p.110202-110202, Article 110202
Hauptverfasser:	Brazel, Erin B., Tan, Aimee, Neville, Stephanie L., Iverson, Amy R., Udagedara, Saumya R., Cunningham, Bliss A., Sikanyika, Mwilye, De Oliveira, David M.P., Keller, Bernhard, Bohlmann, Lisa, El-Deeb, Ibrahim M., Ganio, Katherine, Eijkelkamp, Bart A., McEwan, Alastair G., von Itzstein, Mark, Maher, Megan J., Walker, Mark J., Rosch, Jason W., McDevitt, Christopher A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ampicillin - pharmacology Ampicillin Resistance - genetics Ampicillin Resistance - physiology Animals Anti-Bacterial Agents - pharmacology antibiotics antimicrobial resistance bacterial pathogen Clioquinol - analogs & derivatives Clioquinol - pharmacology Disease Models, Animal Female Homeostasis ionophore Mice Mice, Inbred BALB C Microbial Sensitivity Tests multidrug resistance PBT2 Pneumonia Streptococcus pneumoniae Streptococcus pneumoniae - metabolism zinc Zinc - metabolism zinc intoxication
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