Synthesis of trifluoromethyl-containing isoindolinones from tertiary enamides via a cascade radical addition and cyclization process

A radical trifluoromethylation reaction of tertiary enamides was investigated and trifluoromethyl-containing isoindolinones were prepared under mild conditions. Using TMSCF as a radical source, PhI(OAc) as an oxidant and KHF as an additive, tertiary enamides were converted to isoindolinones a cascad...

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Veröffentlicht in:	RSC advances 2018-01, Vol.8 (42), p.23919-23923
Hauptverfasser:	Yu, Hui, Jiao, Mingdong, Fang, Xiaowei, Xuan, Pengfei
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Organic chemistry
Online-Zugang:	Volltext
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