Loss of function of renal Glut2 reverses hyperglycaemia and normalises body weight in mouse models of diabetes and obesity

Aims/hypothesis Renal GLUT2 is increased in diabetes, thereby enhancing glucose reabsorption and worsening hyperglycaemia. Here, we determined whether loss of Glut2 (also known as Slc2a2 ) specifically in the kidneys would reverse hyperglycaemia and normalise body weight in mouse models of diabetes...

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Veröffentlicht in:	Diabetologia 2022-06, Vol.65 (6), p.1032-1047
Hauptverfasser:	de Souza Cordeiro, Leticia Maria, Bainbridge, Lauren, Devisetty, Nagavardhini, McDougal, David H., Peters, Dorien J. M., Chhabra, Kavaljit H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Blood glucose Blood Glucose - metabolism Body weight Diabetes Diabetes mellitus (insulin dependent) Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - metabolism Disease Models, Animal Female Glucose Glucose - metabolism Glucose tolerance Glucose transporter Glucose Transporter Type 2 Glycosuria - metabolism Homeostasis Human Physiology Humans Hyperglycemia Hyperglycemia - metabolism Insulin Insulin - metabolism Internal Medicine Kidney - metabolism Kidneys Male Medicine Medicine & Public Health Metabolic Diseases Mice Na+/glucose cotransporter Obesity Obesity - genetics Obesity - metabolism Phenotypes Reabsorption Renal function Rodents Sodium-Glucose Transporter 2 - genetics Sodium-Glucose Transporter 2 - metabolism Transcription factors
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