Thymoquinone Induces Downregulation of BCR-ABL/JAK/STAT Pathway and Apoptosis in K562 Leukemia Cells

BCR ABL oncogene encodes the BCR-ABL chimeric protein, which is a constitutively activated non-receptor tyrosine kinase. The BCR-ABL oncoprotein is a key molecular basis for the pathogenesis of chronic myeloid leukemia (CML) via activation of several downstream signaling pathways including JAK/STAT...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Asian Pacific Journal of Cancer Prevention 2021-12, Vol.22 (12), p.3959-3965
Hauptverfasser:	Al-Rawashde, Futoon Abedrabbu, Wan Taib, Wan Rohani, Ismail, Imilia, Johan, Muhammad Farid, Al-Wajeeh, Abdullah Saleh, Al-Jamal, Hamid Ali Nagi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis - drug effects Benzoquinones - pharmacology Down-Regulation - drug effects Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - genetics Genes, abl - drug effects Humans Janus Kinase 2 - drug effects K562 Cells Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Signal Transduction - drug effects Signal Transduction - genetics STAT3 Transcription Factor - drug effects STAT5 Transcription Factor - drug effects Tumor Suppressor Proteins - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!