Chemical metabolomics for investigating the protective effectiveness of Acanthopanax senticosus Harms leaf against acute promyelocytic leukemia
Recent advances in the study of high-throughput metabolomics combined with high-resolution mass spectrometry have accelerated our understanding of the efficacy, mechanisms, and application of natural products. In this study, we have used chemical metabolomics to investigate and discover small molecu...
Gespeichert in:
| Veröffentlicht in: | RSC advances 2018-01, Vol.8 (22), p.11983-11990 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 11990 |
|---|---|
| container_issue | 22 |
| container_start_page | 11983 |
| container_title | RSC advances |
| container_volume | 8 |
| creator | Han, Yue Zhang, Ai-Hua Zhang, Ying-Zhi Sun, Hui Meng, Xiang-Cai Wang, Xi-Jun |
| description | Recent advances in the study of high-throughput metabolomics combined with high-resolution mass spectrometry have accelerated our understanding of the efficacy, mechanisms, and application of natural products. In this study, we have used chemical metabolomics to investigate and discover small molecule metabolites for the potential mechanism of
Harms leaf (ASL) against acute promyelocytic leukemia (APL). Based on high-throughput metabolomics, the underlying biomarker was found by combining chromatography coupled with quadrupole time-of-flight mass spectrometry with multivariate data analysis. The protective effect of ASL was dissected using biochemical indicators, pathology sections, immunohistochemistry, and multivariate analysis. Furthermore, 13 potential biomarkers associated with the pathway of sugar metabolism, amino-acid metabolism, nucleotide metabolism, and the metabolism of arachidonic acid were identified from serum samples. This study would help to understand chemical metabolomics for investigating the anti-APL effectiveness of ASL. |
| doi_str_mv | 10.1039/c8ra01029c |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9079283</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2021475420</sourcerecordid><originalsourceid>FETCH-LOGICAL-c403t-60f7ece68f90d5922ccf54df94c3ca530c455b3eae31cd3487750efa502713313</originalsourceid><addsrcrecordid>eNqFkt9qFDEUxgdRbKm98QEk4I0Iq_k7M7kRlsFaoSCIXoez2ZPd1JlkTTJL9yl8ZdNuLdUbz805IT8-vnP4muYlo-8YFfq97RNQRrm2T5pTTmW74LTVTx_NJ815zte0VqsYb9nz5kQoJbTo2Gnza9ji5C2MZMICqzjG-srExUR82GMufgPFhw0pWyS7FAva4vdI0LnjFDBnEh1ZWghlG3cQ4IZkDMXbmOdMLiFNmYwIjsAGfMiFgJ3Lndh0wDHaQ0UrMP-oRuBF88zBmPH8vp813y8-fhsuF1dfPn0ellcLK6koi5a6Di22vdN0rTTn1jol105LKywoQa1UaiUQUDC7FrLvOkXRgaK8Y0IwcdZ8OOru5tWEa1sNJxjNLvkJ0sFE8Obvn-C3ZhP3RtNO815UgTf3Ain-nOuhzOSzxXGEgHHOhrctV1Jq1f0f5ZxRqfpWVfT1P-h1nFOolzCcciY7JTmt1NsjZVPMOaF78M2ouU2FGfqvy7tUDBV-9XjTB_RPBsRv-1G2Gw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2021475420</pqid></control><display><type>article</type><title>Chemical metabolomics for investigating the protective effectiveness of Acanthopanax senticosus Harms leaf against acute promyelocytic leukemia</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Han, Yue ; Zhang, Ai-Hua ; Zhang, Ying-Zhi ; Sun, Hui ; Meng, Xiang-Cai ; Wang, Xi-Jun</creator><creatorcontrib>Han, Yue ; Zhang, Ai-Hua ; Zhang, Ying-Zhi ; Sun, Hui ; Meng, Xiang-Cai ; Wang, Xi-Jun</creatorcontrib><description>Recent advances in the study of high-throughput metabolomics combined with high-resolution mass spectrometry have accelerated our understanding of the efficacy, mechanisms, and application of natural products. In this study, we have used chemical metabolomics to investigate and discover small molecule metabolites for the potential mechanism of
Harms leaf (ASL) against acute promyelocytic leukemia (APL). Based on high-throughput metabolomics, the underlying biomarker was found by combining chromatography coupled with quadrupole time-of-flight mass spectrometry with multivariate data analysis. The protective effect of ASL was dissected using biochemical indicators, pathology sections, immunohistochemistry, and multivariate analysis. Furthermore, 13 potential biomarkers associated with the pathway of sugar metabolism, amino-acid metabolism, nucleotide metabolism, and the metabolism of arachidonic acid were identified from serum samples. This study would help to understand chemical metabolomics for investigating the anti-APL effectiveness of ASL.</description><identifier>ISSN: 2046-2069</identifier><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/c8ra01029c</identifier><identifier>PMID: 35539371</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Amino acids ; Arachidonic acid ; Biomarkers ; blood serum ; Chemistry ; chromatography ; Data analysis ; Eleutherococcus senticosus ; immunohistochemistry ; leaves ; Leukemia ; Mass spectrometry ; Metabolism ; Metabolites ; metabolomics ; Multivariate analysis ; Natural products ; protective effect ; Quadrupoles ; Scientific imaging ; Spectroscopy ; sugars</subject><ispartof>RSC advances, 2018-01, Vol.8 (22), p.11983-11990</ispartof><rights>This journal is © The Royal Society of Chemistry.</rights><rights>Copyright Royal Society of Chemistry 2018</rights><rights>This journal is © The Royal Society of Chemistry 2018 The Royal Society of Chemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-60f7ece68f90d5922ccf54df94c3ca530c455b3eae31cd3487750efa502713313</citedby><cites>FETCH-LOGICAL-c403t-60f7ece68f90d5922ccf54df94c3ca530c455b3eae31cd3487750efa502713313</cites><orcidid>0000-0001-9375-8280</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079283/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079283/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35539371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, Yue</creatorcontrib><creatorcontrib>Zhang, Ai-Hua</creatorcontrib><creatorcontrib>Zhang, Ying-Zhi</creatorcontrib><creatorcontrib>Sun, Hui</creatorcontrib><creatorcontrib>Meng, Xiang-Cai</creatorcontrib><creatorcontrib>Wang, Xi-Jun</creatorcontrib><title>Chemical metabolomics for investigating the protective effectiveness of Acanthopanax senticosus Harms leaf against acute promyelocytic leukemia</title><title>RSC advances</title><addtitle>RSC Adv</addtitle><description>Recent advances in the study of high-throughput metabolomics combined with high-resolution mass spectrometry have accelerated our understanding of the efficacy, mechanisms, and application of natural products. In this study, we have used chemical metabolomics to investigate and discover small molecule metabolites for the potential mechanism of
Harms leaf (ASL) against acute promyelocytic leukemia (APL). Based on high-throughput metabolomics, the underlying biomarker was found by combining chromatography coupled with quadrupole time-of-flight mass spectrometry with multivariate data analysis. The protective effect of ASL was dissected using biochemical indicators, pathology sections, immunohistochemistry, and multivariate analysis. Furthermore, 13 potential biomarkers associated with the pathway of sugar metabolism, amino-acid metabolism, nucleotide metabolism, and the metabolism of arachidonic acid were identified from serum samples. This study would help to understand chemical metabolomics for investigating the anti-APL effectiveness of ASL.</description><subject>Amino acids</subject><subject>Arachidonic acid</subject><subject>Biomarkers</subject><subject>blood serum</subject><subject>Chemistry</subject><subject>chromatography</subject><subject>Data analysis</subject><subject>Eleutherococcus senticosus</subject><subject>immunohistochemistry</subject><subject>leaves</subject><subject>Leukemia</subject><subject>Mass spectrometry</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>metabolomics</subject><subject>Multivariate analysis</subject><subject>Natural products</subject><subject>protective effect</subject><subject>Quadrupoles</subject><subject>Scientific imaging</subject><subject>Spectroscopy</subject><subject>sugars</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFkt9qFDEUxgdRbKm98QEk4I0Iq_k7M7kRlsFaoSCIXoez2ZPd1JlkTTJL9yl8ZdNuLdUbz805IT8-vnP4muYlo-8YFfq97RNQRrm2T5pTTmW74LTVTx_NJ815zte0VqsYb9nz5kQoJbTo2Gnza9ji5C2MZMICqzjG-srExUR82GMufgPFhw0pWyS7FAva4vdI0LnjFDBnEh1ZWghlG3cQ4IZkDMXbmOdMLiFNmYwIjsAGfMiFgJ3Lndh0wDHaQ0UrMP-oRuBF88zBmPH8vp813y8-fhsuF1dfPn0ellcLK6koi5a6Di22vdN0rTTn1jol105LKywoQa1UaiUQUDC7FrLvOkXRgaK8Y0IwcdZ8OOru5tWEa1sNJxjNLvkJ0sFE8Obvn-C3ZhP3RtNO815UgTf3Ain-nOuhzOSzxXGEgHHOhrctV1Jq1f0f5ZxRqfpWVfT1P-h1nFOolzCcciY7JTmt1NsjZVPMOaF78M2ouU2FGfqvy7tUDBV-9XjTB_RPBsRv-1G2Gw</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Han, Yue</creator><creator>Zhang, Ai-Hua</creator><creator>Zhang, Ying-Zhi</creator><creator>Sun, Hui</creator><creator>Meng, Xiang-Cai</creator><creator>Wang, Xi-Jun</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7S9</scope><scope>L.6</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9375-8280</orcidid></search><sort><creationdate>20180101</creationdate><title>Chemical metabolomics for investigating the protective effectiveness of Acanthopanax senticosus Harms leaf against acute promyelocytic leukemia</title><author>Han, Yue ; Zhang, Ai-Hua ; Zhang, Ying-Zhi ; Sun, Hui ; Meng, Xiang-Cai ; Wang, Xi-Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-60f7ece68f90d5922ccf54df94c3ca530c455b3eae31cd3487750efa502713313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Amino acids</topic><topic>Arachidonic acid</topic><topic>Biomarkers</topic><topic>blood serum</topic><topic>Chemistry</topic><topic>chromatography</topic><topic>Data analysis</topic><topic>Eleutherococcus senticosus</topic><topic>immunohistochemistry</topic><topic>leaves</topic><topic>Leukemia</topic><topic>Mass spectrometry</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>metabolomics</topic><topic>Multivariate analysis</topic><topic>Natural products</topic><topic>protective effect</topic><topic>Quadrupoles</topic><topic>Scientific imaging</topic><topic>Spectroscopy</topic><topic>sugars</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, Yue</creatorcontrib><creatorcontrib>Zhang, Ai-Hua</creatorcontrib><creatorcontrib>Zhang, Ying-Zhi</creatorcontrib><creatorcontrib>Sun, Hui</creatorcontrib><creatorcontrib>Meng, Xiang-Cai</creatorcontrib><creatorcontrib>Wang, Xi-Jun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Yue</au><au>Zhang, Ai-Hua</au><au>Zhang, Ying-Zhi</au><au>Sun, Hui</au><au>Meng, Xiang-Cai</au><au>Wang, Xi-Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemical metabolomics for investigating the protective effectiveness of Acanthopanax senticosus Harms leaf against acute promyelocytic leukemia</atitle><jtitle>RSC advances</jtitle><addtitle>RSC Adv</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>8</volume><issue>22</issue><spage>11983</spage><epage>11990</epage><pages>11983-11990</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>Recent advances in the study of high-throughput metabolomics combined with high-resolution mass spectrometry have accelerated our understanding of the efficacy, mechanisms, and application of natural products. In this study, we have used chemical metabolomics to investigate and discover small molecule metabolites for the potential mechanism of
Harms leaf (ASL) against acute promyelocytic leukemia (APL). Based on high-throughput metabolomics, the underlying biomarker was found by combining chromatography coupled with quadrupole time-of-flight mass spectrometry with multivariate data analysis. The protective effect of ASL was dissected using biochemical indicators, pathology sections, immunohistochemistry, and multivariate analysis. Furthermore, 13 potential biomarkers associated with the pathway of sugar metabolism, amino-acid metabolism, nucleotide metabolism, and the metabolism of arachidonic acid were identified from serum samples. This study would help to understand chemical metabolomics for investigating the anti-APL effectiveness of ASL.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>35539371</pmid><doi>10.1039/c8ra01029c</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-9375-8280</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2046-2069 |
| ispartof | RSC advances, 2018-01, Vol.8 (22), p.11983-11990 |
| issn | 2046-2069 2046-2069 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9079283 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Amino acids Arachidonic acid Biomarkers blood serum Chemistry chromatography Data analysis Eleutherococcus senticosus immunohistochemistry leaves Leukemia Mass spectrometry Metabolism Metabolites metabolomics Multivariate analysis Natural products protective effect Quadrupoles Scientific imaging Spectroscopy sugars |
| title | Chemical metabolomics for investigating the protective effectiveness of Acanthopanax senticosus Harms leaf against acute promyelocytic leukemia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T10%3A20%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chemical%20metabolomics%20for%20investigating%20the%20protective%20effectiveness%20of%20Acanthopanax%20senticosus%20Harms%20leaf%20against%20acute%20promyelocytic%20leukemia&rft.jtitle=RSC%20advances&rft.au=Han,%20Yue&rft.date=2018-01-01&rft.volume=8&rft.issue=22&rft.spage=11983&rft.epage=11990&rft.pages=11983-11990&rft.issn=2046-2069&rft.eissn=2046-2069&rft_id=info:doi/10.1039/c8ra01029c&rft_dat=%3Cproquest_pubme%3E2021475420%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2021475420&rft_id=info:pmid/35539371&rfr_iscdi=true |