Ligands with polyfluorophenyl moieties promote a local structural rearrangement in the Spinach2 and Broccoli aptamers that increases ligand affinities

The interaction of nucleic acids with their molecular targets often involves structural reorganization that may traverse a complex folding landscape. With the more recent recognition that many RNAs, both coding and noncoding, may regulate cellular activities by interacting with target molecules, it...

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Veröffentlicht in:	RNA (Cambridge) 2022-06, Vol.28 (6), p.865-877
Hauptverfasser:	Anisuzzaman, Sharif, Geraskin, Ivan M, Ilgu, Muslum, Bendickson, Lee, Kraus, George A, Nilsen-Hamilton, Marit
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Aptamers Aptamers, Nucleotide - chemistry Brassica Ligands Nucleic Acid Conformation Nucleic acids RNA - chemistry Vegetables
Online-Zugang:	Volltext
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