Obviation of dyslipidemia by garlic oil and its organosulfur compound, diallyl disulphide, in experimental animals
Garlic and its number of preparations are known to be effective for treatment of dyslipidemia, but the data about the specific active constituents of the garlic on the possible therapeutic value is scarce. Therefore, the aim of this research was to evaluate the role of garlic oil (GO) and its active...
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creator | Mohammed Basheeruddin Asdaq, Syed Yasmin, Farhana Alsalman, Abdulkhaliq J. Al mohaini, Mohammed Kamal, Mehnaz Al Hawaj, Maitham A. Alsalman, Khaled J. Imran, Mohd Sreeharsha, Nagaraja |
description | Garlic and its number of preparations are known to be effective for treatment of dyslipidemia, but the data about the specific active constituents of the garlic on the possible therapeutic value is scarce. Therefore, the aim of this research was to evaluate the role of garlic oil (GO) and its active element, diallyl disulphide (DADS) for obviating dyslipidemia in animal model.
High fat diet (HFD) was given to animals to induce dyslipidemia. Animals of HFD groups were fed with atherogenic diet for 15 days prior to treatment. Animals in their respective groups received vehicle, GO (50 and 100 mg/kg), and DADS (4.47 and 8.94 mg/kg) for five consecutive days. Lipid profiles were estimated in serum, oxidant/antioxidant and liver profile were measured in liver tissue homogenate (LTH).
Animals fed on HFD developed significant increase in the serum levels of triglycerides (TG), total cholesterol (TC), lactate dehydrogenase (LDL), malondialdehyde (MDA), glutathione peroxidase (GSHPx), glutathione (GSH), and glutathione disulfide (GSSG) that reduced significantly in groups that received GO and DADS treatments. Additionally, significant elevation in serum high density lipoprotein (HDL) level was observed in animals that received GO and DADS. Moreover, hepatic markers such as alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine transferase (ALT), that were abnormally altered by high fat diet, were significantly restored to almost normal values with GO and DADS treatments. Also, antioxidants such as superoxide dismutase (SOD), catalase (CAT), ferric reducing antioxidant power (FRAP), and total thiol (SH) levels in LTH were increased significantly in GO and DADS treated groups. When compared to DADS, GO showed better therapeutic effectiveness in terms of antihyperlipidemic and antioxidant properties.
In hyperlipidemic rats, garlic and its principal active component, diallyl disulphide, were effective in avoiding dyslipidemia and neutralizing reactive free radicals induced by a high fat diet. It's an intriguing observation that GO has a larger therapeutic influence than its active constituent, DADS. These findings suggest that other constituents, in addition to GO's DADS, are involved in the compound's synergistic antihyperlipidemic and antioxidant activities. |
doi_str_mv | 10.1016/j.sjbs.2021.12.025 |
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High fat diet (HFD) was given to animals to induce dyslipidemia. Animals of HFD groups were fed with atherogenic diet for 15 days prior to treatment. Animals in their respective groups received vehicle, GO (50 and 100 mg/kg), and DADS (4.47 and 8.94 mg/kg) for five consecutive days. Lipid profiles were estimated in serum, oxidant/antioxidant and liver profile were measured in liver tissue homogenate (LTH).
Animals fed on HFD developed significant increase in the serum levels of triglycerides (TG), total cholesterol (TC), lactate dehydrogenase (LDL), malondialdehyde (MDA), glutathione peroxidase (GSHPx), glutathione (GSH), and glutathione disulfide (GSSG) that reduced significantly in groups that received GO and DADS treatments. Additionally, significant elevation in serum high density lipoprotein (HDL) level was observed in animals that received GO and DADS. Moreover, hepatic markers such as alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine transferase (ALT), that were abnormally altered by high fat diet, were significantly restored to almost normal values with GO and DADS treatments. Also, antioxidants such as superoxide dismutase (SOD), catalase (CAT), ferric reducing antioxidant power (FRAP), and total thiol (SH) levels in LTH were increased significantly in GO and DADS treated groups. When compared to DADS, GO showed better therapeutic effectiveness in terms of antihyperlipidemic and antioxidant properties.
In hyperlipidemic rats, garlic and its principal active component, diallyl disulphide, were effective in avoiding dyslipidemia and neutralizing reactive free radicals induced by a high fat diet. It's an intriguing observation that GO has a larger therapeutic influence than its active constituent, DADS. These findings suggest that other constituents, in addition to GO's DADS, are involved in the compound's synergistic antihyperlipidemic and antioxidant activities.</description><identifier>ISSN: 1319-562X</identifier><identifier>EISSN: 2213-7106</identifier><identifier>DOI: 10.1016/j.sjbs.2021.12.025</identifier><identifier>PMID: 35531198</identifier><language>eng</language><publisher>Saudi Arabia: Elsevier B.V</publisher><subject>Antihyperlipidemic ; Antioxidant ; Diallyl disulphide ; Garlic oil ; High fat diet ; Original</subject><ispartof>Saudi journal of biological sciences, 2022-04, Vol.29 (4), p.2520-2525</ispartof><rights>2021 The Author(s)</rights><rights>2021 The Author(s).</rights><rights>2021 The Author(s) 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-300291eca3a228399479fd4c5eff23f912c8bc82e10e778b2480a98029474c053</citedby><cites>FETCH-LOGICAL-c455t-300291eca3a228399479fd4c5eff23f912c8bc82e10e778b2480a98029474c053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072925/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1319562X21010585$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,3537,27901,27902,53766,53768,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35531198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohammed Basheeruddin Asdaq, Syed</creatorcontrib><creatorcontrib>Yasmin, Farhana</creatorcontrib><creatorcontrib>Alsalman, Abdulkhaliq J.</creatorcontrib><creatorcontrib>Al mohaini, Mohammed</creatorcontrib><creatorcontrib>Kamal, Mehnaz</creatorcontrib><creatorcontrib>Al Hawaj, Maitham A.</creatorcontrib><creatorcontrib>Alsalman, Khaled J.</creatorcontrib><creatorcontrib>Imran, Mohd</creatorcontrib><creatorcontrib>Sreeharsha, Nagaraja</creatorcontrib><title>Obviation of dyslipidemia by garlic oil and its organosulfur compound, diallyl disulphide, in experimental animals</title><title>Saudi journal of biological sciences</title><addtitle>Saudi J Biol Sci</addtitle><description>Garlic and its number of preparations are known to be effective for treatment of dyslipidemia, but the data about the specific active constituents of the garlic on the possible therapeutic value is scarce. Therefore, the aim of this research was to evaluate the role of garlic oil (GO) and its active element, diallyl disulphide (DADS) for obviating dyslipidemia in animal model.
High fat diet (HFD) was given to animals to induce dyslipidemia. Animals of HFD groups were fed with atherogenic diet for 15 days prior to treatment. Animals in their respective groups received vehicle, GO (50 and 100 mg/kg), and DADS (4.47 and 8.94 mg/kg) for five consecutive days. Lipid profiles were estimated in serum, oxidant/antioxidant and liver profile were measured in liver tissue homogenate (LTH).
Animals fed on HFD developed significant increase in the serum levels of triglycerides (TG), total cholesterol (TC), lactate dehydrogenase (LDL), malondialdehyde (MDA), glutathione peroxidase (GSHPx), glutathione (GSH), and glutathione disulfide (GSSG) that reduced significantly in groups that received GO and DADS treatments. Additionally, significant elevation in serum high density lipoprotein (HDL) level was observed in animals that received GO and DADS. Moreover, hepatic markers such as alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine transferase (ALT), that were abnormally altered by high fat diet, were significantly restored to almost normal values with GO and DADS treatments. Also, antioxidants such as superoxide dismutase (SOD), catalase (CAT), ferric reducing antioxidant power (FRAP), and total thiol (SH) levels in LTH were increased significantly in GO and DADS treated groups. When compared to DADS, GO showed better therapeutic effectiveness in terms of antihyperlipidemic and antioxidant properties.
In hyperlipidemic rats, garlic and its principal active component, diallyl disulphide, were effective in avoiding dyslipidemia and neutralizing reactive free radicals induced by a high fat diet. It's an intriguing observation that GO has a larger therapeutic influence than its active constituent, DADS. These findings suggest that other constituents, in addition to GO's DADS, are involved in the compound's synergistic antihyperlipidemic and antioxidant activities.</description><subject>Antihyperlipidemic</subject><subject>Antioxidant</subject><subject>Diallyl disulphide</subject><subject>Garlic oil</subject><subject>High fat diet</subject><subject>Original</subject><issn>1319-562X</issn><issn>2213-7106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kc2LFDEQxYMo7rj6D3iQHD1st0mlPxIQQRa_YGEvCt5COp2erSHdaZPuwfnvTTvrohdP71CvfvWoR8hLzkrOePPmUKZDl0pgwEsOJYP6EdkBcFG0nDWPyY4Lroq6ge8X5FlKB8YaKSR_Si5EXQvOldyReNsd0SwYJhoG2p-Sxxl7N6Kh3YnuTfRoaUBPzdRTXBINcW-mkFY_rJHaMM5hnfor2qPx_uSz5tF8lxFXFCfqfs4u4uimxWwIHI1Pz8mTIYt7ca-X5NvHD1-vPxc3t5--XL-_KWxV10shGAPFnTXCAEihVNWqoa9s7YYBxKA4WNlZCY4z17ayg0oyo2ReqtrKslpckndn7rx2o-ttDhGN13POY-JJB4P638mEd3ofjlqxFhRsgNf3gBh-rC4tesRknfdmcmFNGpqGV1IAl9kKZ6uNIaXohocznOmtLH3QW1l6K0tz0Ow3_9XfAR9W_rSTDW_PBpffdEQXdbLoJut6jM4uug_4P_4vSCmohg</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Mohammed Basheeruddin Asdaq, Syed</creator><creator>Yasmin, Farhana</creator><creator>Alsalman, Abdulkhaliq J.</creator><creator>Al mohaini, Mohammed</creator><creator>Kamal, Mehnaz</creator><creator>Al Hawaj, Maitham A.</creator><creator>Alsalman, Khaled J.</creator><creator>Imran, Mohd</creator><creator>Sreeharsha, Nagaraja</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220401</creationdate><title>Obviation of dyslipidemia by garlic oil and its organosulfur compound, diallyl disulphide, in experimental animals</title><author>Mohammed Basheeruddin Asdaq, Syed ; Yasmin, Farhana ; Alsalman, Abdulkhaliq J. ; Al mohaini, Mohammed ; Kamal, Mehnaz ; Al Hawaj, Maitham A. ; Alsalman, Khaled J. ; Imran, Mohd ; Sreeharsha, Nagaraja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-300291eca3a228399479fd4c5eff23f912c8bc82e10e778b2480a98029474c053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antihyperlipidemic</topic><topic>Antioxidant</topic><topic>Diallyl disulphide</topic><topic>Garlic oil</topic><topic>High fat diet</topic><topic>Original</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohammed Basheeruddin Asdaq, Syed</creatorcontrib><creatorcontrib>Yasmin, Farhana</creatorcontrib><creatorcontrib>Alsalman, Abdulkhaliq J.</creatorcontrib><creatorcontrib>Al mohaini, Mohammed</creatorcontrib><creatorcontrib>Kamal, Mehnaz</creatorcontrib><creatorcontrib>Al Hawaj, Maitham A.</creatorcontrib><creatorcontrib>Alsalman, Khaled J.</creatorcontrib><creatorcontrib>Imran, Mohd</creatorcontrib><creatorcontrib>Sreeharsha, Nagaraja</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Saudi journal of biological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohammed Basheeruddin Asdaq, Syed</au><au>Yasmin, Farhana</au><au>Alsalman, Abdulkhaliq J.</au><au>Al mohaini, Mohammed</au><au>Kamal, Mehnaz</au><au>Al Hawaj, Maitham A.</au><au>Alsalman, Khaled J.</au><au>Imran, Mohd</au><au>Sreeharsha, Nagaraja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obviation of dyslipidemia by garlic oil and its organosulfur compound, diallyl disulphide, in experimental animals</atitle><jtitle>Saudi journal of biological sciences</jtitle><addtitle>Saudi J Biol Sci</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>29</volume><issue>4</issue><spage>2520</spage><epage>2525</epage><pages>2520-2525</pages><issn>1319-562X</issn><eissn>2213-7106</eissn><abstract>Garlic and its number of preparations are known to be effective for treatment of dyslipidemia, but the data about the specific active constituents of the garlic on the possible therapeutic value is scarce. Therefore, the aim of this research was to evaluate the role of garlic oil (GO) and its active element, diallyl disulphide (DADS) for obviating dyslipidemia in animal model.
High fat diet (HFD) was given to animals to induce dyslipidemia. Animals of HFD groups were fed with atherogenic diet for 15 days prior to treatment. Animals in their respective groups received vehicle, GO (50 and 100 mg/kg), and DADS (4.47 and 8.94 mg/kg) for five consecutive days. Lipid profiles were estimated in serum, oxidant/antioxidant and liver profile were measured in liver tissue homogenate (LTH).
Animals fed on HFD developed significant increase in the serum levels of triglycerides (TG), total cholesterol (TC), lactate dehydrogenase (LDL), malondialdehyde (MDA), glutathione peroxidase (GSHPx), glutathione (GSH), and glutathione disulfide (GSSG) that reduced significantly in groups that received GO and DADS treatments. Additionally, significant elevation in serum high density lipoprotein (HDL) level was observed in animals that received GO and DADS. Moreover, hepatic markers such as alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine transferase (ALT), that were abnormally altered by high fat diet, were significantly restored to almost normal values with GO and DADS treatments. Also, antioxidants such as superoxide dismutase (SOD), catalase (CAT), ferric reducing antioxidant power (FRAP), and total thiol (SH) levels in LTH were increased significantly in GO and DADS treated groups. When compared to DADS, GO showed better therapeutic effectiveness in terms of antihyperlipidemic and antioxidant properties.
In hyperlipidemic rats, garlic and its principal active component, diallyl disulphide, were effective in avoiding dyslipidemia and neutralizing reactive free radicals induced by a high fat diet. It's an intriguing observation that GO has a larger therapeutic influence than its active constituent, DADS. These findings suggest that other constituents, in addition to GO's DADS, are involved in the compound's synergistic antihyperlipidemic and antioxidant activities.</abstract><cop>Saudi Arabia</cop><pub>Elsevier B.V</pub><pmid>35531198</pmid><doi>10.1016/j.sjbs.2021.12.025</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Antihyperlipidemic Antioxidant Diallyl disulphide Garlic oil High fat diet Original |
title | Obviation of dyslipidemia by garlic oil and its organosulfur compound, diallyl disulphide, in experimental animals |
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