Biological Effect of Quercetin in Repairing Brain Damage and Cerebral Changes in Rats: Molecular Docking and In Vivo Studies
This study examined the protective effect of quercetin against high-altitude-induced brain damage in rats. A molecular docking study was performed to investigate the potential effect of quercetin in reducing brain damages through its ability to target the oxidative stress enzymes. Biomarker assessme...
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| creator | Mehany, Ahmed B. M. Belal, Amany Santali, Eman Y. Shaaban, Salwa Abourehab, Mohammad A. S. El-Feky, Ola A. Diab, Mahmoud Abou Galala, Fawzy M. A. Elkaeed, Eslam B. Abdelhamid, Ghada |
| description | This study examined the protective effect of quercetin against high-altitude-induced brain damage in rats. A molecular docking study was performed to investigate the potential effect of quercetin in reducing brain damages through its ability to target the oxidative stress enzymes. Biomarker assessment screening assays were also performed then followed by in vivo studies. Three groups of rats were divided into the control group, an untreated animal model group with induced brain damage, and finally, the quercetin treated group that received quercetin dose equal to 20 mg/kg of their body weights. Molecular docking studies and biomarker assessment screening assays proved the potential effect of quercetin to affect the level of representative biomarkers glutathione (GSH), glutathione reductase (GR), glutathione-S-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA). Additionally, the protective effect of quercetin against high altitude, low pressure, and low oxygen was also investigated by exploring the brain histopathology of experimental rats. Brain damage was observed in the untreated animal model group. After treatment with quercetin, the cerebral edema in the brain tissues was improved significantly, confirming the protective effects of quercetin. Therefore, quercetin can be used as a natural food additive to protect from the highaltitude-induced brain damage. |
| doi_str_mv | 10.1155/2022/8962149 |
| format | Article |
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M. ; Belal, Amany ; Santali, Eman Y. ; Shaaban, Salwa ; Abourehab, Mohammad A. S. ; El-Feky, Ola A. ; Diab, Mahmoud ; Abou Galala, Fawzy M. A. ; Elkaeed, Eslam B. ; Abdelhamid, Ghada</creator><contributor>Husain, Kazim</contributor><creatorcontrib>Mehany, Ahmed B. M. ; Belal, Amany ; Santali, Eman Y. ; Shaaban, Salwa ; Abourehab, Mohammad A. S. ; El-Feky, Ola A. ; Diab, Mahmoud ; Abou Galala, Fawzy M. A. ; Elkaeed, Eslam B. ; Abdelhamid, Ghada ; Husain, Kazim</creatorcontrib><description>This study examined the protective effect of quercetin against high-altitude-induced brain damage in rats. A molecular docking study was performed to investigate the potential effect of quercetin in reducing brain damages through its ability to target the oxidative stress enzymes. Biomarker assessment screening assays were also performed then followed by in vivo studies. Three groups of rats were divided into the control group, an untreated animal model group with induced brain damage, and finally, the quercetin treated group that received quercetin dose equal to 20 mg/kg of their body weights. Molecular docking studies and biomarker assessment screening assays proved the potential effect of quercetin to affect the level of representative biomarkers glutathione (GSH), glutathione reductase (GR), glutathione-S-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA). Additionally, the protective effect of quercetin against high altitude, low pressure, and low oxygen was also investigated by exploring the brain histopathology of experimental rats. Brain damage was observed in the untreated animal model group. After treatment with quercetin, the cerebral edema in the brain tissues was improved significantly, confirming the protective effects of quercetin. Therefore, quercetin can be used as a natural food additive to protect from the highaltitude-induced brain damage.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2022/8962149</identifier><identifier>PMID: 35528172</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Altitude ; Alzheimer's disease ; Animal models ; Antioxidants ; Binding sites ; Biological effects ; Biomarkers ; Brain ; Brain damage ; Brain injury ; Brain research ; Care and treatment ; Catalase ; Cerebral edema ; Chemical properties ; Development and progression ; Edema ; Enzymes ; Food additives ; Free radicals ; Glutathione ; Glutathione peroxidase ; Glutathione reductase ; Glutathione transferase ; Health aspects ; High altitude ; High-altitude environments ; Histopathology ; Homogenization ; Hypoxia ; In vivo methods and tests ; Ligands ; Low pressure ; Molecular docking ; Natural & organic foods ; Natural products ; Neuroprotective agents ; Oxidative stress ; Peroxidase ; Pharmacology, Experimental ; Proteins ; Quercetin ; Reductases ; Screening ; Simulation ; Superoxide dismutase</subject><ispartof>BioMed research international, 2022, Vol.2022 (1), p.8962149-8962149</ispartof><rights>Copyright © 2022 Ahmed B. M. Mehany et al.</rights><rights>COPYRIGHT 2022 John Wiley & Sons, Inc.</rights><rights>Copyright © 2022 Ahmed B. M. Mehany et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Ahmed B. M. Mehany et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-531b745d1539602fff3d76b7c7a193b90d6335505a0f803f52cd878f8c9bdac83</citedby><cites>FETCH-LOGICAL-c406t-531b745d1539602fff3d76b7c7a193b90d6335505a0f803f52cd878f8c9bdac83</cites><orcidid>0000-0002-2546-8035 ; 0000-0002-9913-5380 ; 0000-0003-1348-6567 ; 0000-0003-1045-0163 ; 0000-0001-6269-806X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071882/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071882/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35528172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Husain, Kazim</contributor><creatorcontrib>Mehany, Ahmed B. M.</creatorcontrib><creatorcontrib>Belal, Amany</creatorcontrib><creatorcontrib>Santali, Eman Y.</creatorcontrib><creatorcontrib>Shaaban, Salwa</creatorcontrib><creatorcontrib>Abourehab, Mohammad A. S.</creatorcontrib><creatorcontrib>El-Feky, Ola A.</creatorcontrib><creatorcontrib>Diab, Mahmoud</creatorcontrib><creatorcontrib>Abou Galala, Fawzy M. A.</creatorcontrib><creatorcontrib>Elkaeed, Eslam B.</creatorcontrib><creatorcontrib>Abdelhamid, Ghada</creatorcontrib><title>Biological Effect of Quercetin in Repairing Brain Damage and Cerebral Changes in Rats: Molecular Docking and In Vivo Studies</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>This study examined the protective effect of quercetin against high-altitude-induced brain damage in rats. A molecular docking study was performed to investigate the potential effect of quercetin in reducing brain damages through its ability to target the oxidative stress enzymes. Biomarker assessment screening assays were also performed then followed by in vivo studies. Three groups of rats were divided into the control group, an untreated animal model group with induced brain damage, and finally, the quercetin treated group that received quercetin dose equal to 20 mg/kg of their body weights. Molecular docking studies and biomarker assessment screening assays proved the potential effect of quercetin to affect the level of representative biomarkers glutathione (GSH), glutathione reductase (GR), glutathione-S-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA). Additionally, the protective effect of quercetin against high altitude, low pressure, and low oxygen was also investigated by exploring the brain histopathology of experimental rats. Brain damage was observed in the untreated animal model group. After treatment with quercetin, the cerebral edema in the brain tissues was improved significantly, confirming the protective effects of quercetin. Therefore, quercetin can be used as a natural food additive to protect from the highaltitude-induced brain damage.</description><subject>Altitude</subject><subject>Alzheimer's disease</subject><subject>Animal models</subject><subject>Antioxidants</subject><subject>Binding sites</subject><subject>Biological effects</subject><subject>Biomarkers</subject><subject>Brain</subject><subject>Brain damage</subject><subject>Brain injury</subject><subject>Brain research</subject><subject>Care and treatment</subject><subject>Catalase</subject><subject>Cerebral edema</subject><subject>Chemical properties</subject><subject>Development and progression</subject><subject>Edema</subject><subject>Enzymes</subject><subject>Food additives</subject><subject>Free radicals</subject><subject>Glutathione</subject><subject>Glutathione peroxidase</subject><subject>Glutathione reductase</subject><subject>Glutathione transferase</subject><subject>Health aspects</subject><subject>High altitude</subject><subject>High-altitude environments</subject><subject>Histopathology</subject><subject>Homogenization</subject><subject>Hypoxia</subject><subject>In vivo methods and tests</subject><subject>Ligands</subject><subject>Low pressure</subject><subject>Molecular docking</subject><subject>Natural & organic foods</subject><subject>Natural products</subject><subject>Neuroprotective agents</subject><subject>Oxidative stress</subject><subject>Peroxidase</subject><subject>Pharmacology, Experimental</subject><subject>Proteins</subject><subject>Quercetin</subject><subject>Reductases</subject><subject>Screening</subject><subject>Simulation</subject><subject>Superoxide dismutase</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kdtrFDEYxYMottS--SwBXwRdm8skk_ggtNuqhYp4fQ2ZXGZTZ5M1makI_vFm3HWpPhgCScjvO_lODgAPMXqOMWMnBBFyIiQnuJF3wCGhuFlw3OC7-z2lB-C4lGtUh8AcSX4fHFDGiMAtOQQ_z0IaUh-MHuCF986MMHn4fnLZuDFEWOcHt9Ehh9jDs6zr-Vyvde-gjhYuXXZdrqXLlY69K79xPZYX8G0anJkGneF5Ml_n4pm_jPBLuEnw4zjZ4MoDcM_robjj3XoEPr-6-LR8s7h69_pyeXq1MA3i44JR3LUNs5hRyRHx3lPb8q41rcaSdhJZTqsjxDTyAlHPiLGiFV4Y2VltBD0CL7e6m6lbO2tcHGvTapPDWucfKumg_r6JYaX6dKMkarEQpAo82Qnk9G1yZVTrUIwbBh1dmooivH66aATCFX38D3qdphyrvZlCLWswu0X1enAqRJ_qu2YWVactIpJySmbq2ZYyOZWSnd-3jJGa81dz_mqXf8Uf3ba5h_-kXYGnW2AVotXfw__lfgEuF7Wf</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Mehany, Ahmed B. 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M. ; Belal, Amany ; Santali, Eman Y. ; Shaaban, Salwa ; Abourehab, Mohammad A. S. ; El-Feky, Ola A. ; Diab, Mahmoud ; Abou Galala, Fawzy M. 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M.</au><au>Belal, Amany</au><au>Santali, Eman Y.</au><au>Shaaban, Salwa</au><au>Abourehab, Mohammad A. S.</au><au>El-Feky, Ola A.</au><au>Diab, Mahmoud</au><au>Abou Galala, Fawzy M. A.</au><au>Elkaeed, Eslam B.</au><au>Abdelhamid, Ghada</au><au>Husain, Kazim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biological Effect of Quercetin in Repairing Brain Damage and Cerebral Changes in Rats: Molecular Docking and In Vivo Studies</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2022</date><risdate>2022</risdate><volume>2022</volume><issue>1</issue><spage>8962149</spage><epage>8962149</epage><pages>8962149-8962149</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>This study examined the protective effect of quercetin against high-altitude-induced brain damage in rats. A molecular docking study was performed to investigate the potential effect of quercetin in reducing brain damages through its ability to target the oxidative stress enzymes. Biomarker assessment screening assays were also performed then followed by in vivo studies. Three groups of rats were divided into the control group, an untreated animal model group with induced brain damage, and finally, the quercetin treated group that received quercetin dose equal to 20 mg/kg of their body weights. Molecular docking studies and biomarker assessment screening assays proved the potential effect of quercetin to affect the level of representative biomarkers glutathione (GSH), glutathione reductase (GR), glutathione-S-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA). Additionally, the protective effect of quercetin against high altitude, low pressure, and low oxygen was also investigated by exploring the brain histopathology of experimental rats. Brain damage was observed in the untreated animal model group. After treatment with quercetin, the cerebral edema in the brain tissues was improved significantly, confirming the protective effects of quercetin. Therefore, quercetin can be used as a natural food additive to protect from the highaltitude-induced brain damage.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>35528172</pmid><doi>10.1155/2022/8962149</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-2546-8035</orcidid><orcidid>https://orcid.org/0000-0002-9913-5380</orcidid><orcidid>https://orcid.org/0000-0003-1348-6567</orcidid><orcidid>https://orcid.org/0000-0003-1045-0163</orcidid><orcidid>https://orcid.org/0000-0001-6269-806X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Open Access; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Altitude Alzheimer's disease Animal models Antioxidants Binding sites Biological effects Biomarkers Brain Brain damage Brain injury Brain research Care and treatment Catalase Cerebral edema Chemical properties Development and progression Edema Enzymes Food additives Free radicals Glutathione Glutathione peroxidase Glutathione reductase Glutathione transferase Health aspects High altitude High-altitude environments Histopathology Homogenization Hypoxia In vivo methods and tests Ligands Low pressure Molecular docking Natural & organic foods Natural products Neuroprotective agents Oxidative stress Peroxidase Pharmacology, Experimental Proteins Quercetin Reductases Screening Simulation Superoxide dismutase |
| title | Biological Effect of Quercetin in Repairing Brain Damage and Cerebral Changes in Rats: Molecular Docking and In Vivo Studies |
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