The mechanism of activation of MEK1 by B-Raf and KSR1

MEK1 interactions with B-Raf and KSR1 are key steps in Ras/Raf/MEK/ERK signaling. Despite this, vital mechanistic details of how these execute signal transduction are still enigmatic. Among these is why, despite B-Raf and KSR1 kinase domains similarity, the B-Raf/MEK1 and KSR1/MEK1 complexes have di...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2022-05, Vol.79 (5), p.281-281, Article 281
Hauptverfasser:	Maloney, Ryan C., Zhang, Mingzhen, Liu, Yonglan, Jang, Hyunbum, Nussinov, Ruth
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Extracellular signal-regulated kinase Kinases Life Sciences MAP Kinase Kinase 1 - chemistry MAP Kinase Kinase 1 - metabolism Molecular dynamics Original Original Article Phosphorylation Protein kinase Protein Kinases - metabolism Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins B-raf - metabolism Proto-Oncogene Proteins c-raf - metabolism Raf protein Signal Transduction
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