Characterization of a vaccine-elicited human antibody with sequence homology to VRC01-class antibodies that binds the C1C2 gp120 domain

Broadly HIV-1-neutralizing VRC01-class antibodies bind the CD4-binding site of Env and contain V 1-2*02-derived heavy chains paired with light chains expressing five-amino acid-long CDRL3s. Their unmutated germline forms do not recognize HIV-1 Env, and their lack of elicitation in human clinical tri...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Science advances 2022-05, Vol.8 (18), p.eabm3948
Hauptverfasser:	Gray, Matthew D, Feng, Junli, Weidle, Connor E, Cohen, Kristen W, Ballweber-Fleming, Lamar, MacCamy, Anna J, Huynh, Crystal N, Trichka, Josephine J, Montefiori, David, Ferrari, Guido, Pancera, Marie, McElrath, M Juliana, Stamatatos, Leonidas
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Neutralizing Biomedicine and Life Sciences Broadly Neutralizing Antibodies Health and Medicine HIV Antibodies - chemistry HIV-1 Humans Immunology SciAdv r-articles Sequence Homology Vaccines
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!