Glomerular endothelial cell-podocyte stresses and crosstalk in structurally normal kidney transplants

Increased podocyte detachment begins immediately after kidney transplantation and is associated with long-term allograft failure. We hypothesized that cell-specific transcriptional changes in podocytes and glomerular endothelial cells after transplantation would offer mechanistic insights into the p...

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Veröffentlicht in:	Kidney international 2022-04, Vol.101 (4), p.779-792
Hauptverfasser:	Menon, Rajasree, Otto, Edgar A., Berthier, Celine C., Nair, Viji, Farkash, Evan A., Hodgin, Jeffrey B., Yang, Yingbao, Luo, Jinghui, Woodside, Kenneth J., Zamani, Haniyeh, Norman, Silas P., Wiggins, Roger C., Kretzler, Matthias, Naik, Abhijit S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Endothelial Cells Female Glomerular Basement Membrane - pathology glomerulosclerosis Humans Hypertrophy integrin Integrin alpha3 - metabolism Kidney Diseases - pathology kidney transplantation Kidney Transplantation - adverse effects Male podocytes Podocytes - pathology
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