Disturbed expression of vitamin D and retinoic acid‐related orphan receptors α and γ and of megalin in inflammatory skin diseases
The pathogenesis of inflammatory skin diseases is associated with the abnormal activity of keratinocytes and immune cells infiltrate. Vitamin D3 deficiency can correlate with the increased incidence, severity and duration of inflammatory skin disorders. The exact mechanism on how vitamin D3 influenc...
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| Veröffentlicht in: | Experimental dermatology 2022-05, Vol.31 (5), p.781-788 |
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| creator | Brożyna, Anna A. Żmijewski, Michał A. Linowiecka, Kinga Kim, Tae‐Kang Slominski, Radomir M. Slominski, Andrzej T. |
| description | The pathogenesis of inflammatory skin diseases is associated with the abnormal activity of keratinocytes and immune cells infiltrate. Vitamin D3 deficiency can correlate with the increased incidence, severity and duration of inflammatory skin disorders. The exact mechanism on how vitamin D3 influences inflammatory skin diseases still requires clarification. However, it can be associated with the disturbances in transmembrane glycoprotein—LRP2/megalin, which is implicated in vitamin D3 transport to the cell, and defects in vitamin D‐signalling through the nuclear receptors. Therefore, by using immunohistochemistry, we analysed the expression of LRP2/megalin, VDR, RORα and RORγ in allergic contact dermatitis, lichen simplex chronicus, sarcoidosis and psoriasis in comparison with the normal skin. We observed decreased expression of LRP2/megalin in all inflammatory lesions in comparison with the normal skin. Significant differences were also noticed in VDR, RORα and RORγ levels between inflammatory lesions and normal skin. Our research indicates disturbed expression of LRP2/megalin, VDR, RORα and RORγ in inflammatory skin lesions in comparison with normal skin. Therefore, we suggest that changes in the activity of these proteins may play role in pathogenesis of inflammatory skin disorders. Furthermore, we suggest that LRP2/megalin, VDR, RORα and RORy may serve as targets in therapy of these diseases. |
| doi_str_mv | 10.1111/exd.14521 |
| format | Article |
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Vitamin D3 deficiency can correlate with the increased incidence, severity and duration of inflammatory skin disorders. The exact mechanism on how vitamin D3 influences inflammatory skin diseases still requires clarification. However, it can be associated with the disturbances in transmembrane glycoprotein—LRP2/megalin, which is implicated in vitamin D3 transport to the cell, and defects in vitamin D‐signalling through the nuclear receptors. Therefore, by using immunohistochemistry, we analysed the expression of LRP2/megalin, VDR, RORα and RORγ in allergic contact dermatitis, lichen simplex chronicus, sarcoidosis and psoriasis in comparison with the normal skin. We observed decreased expression of LRP2/megalin in all inflammatory lesions in comparison with the normal skin. Significant differences were also noticed in VDR, RORα and RORγ levels between inflammatory lesions and normal skin. Our research indicates disturbed expression of LRP2/megalin, VDR, RORα and RORγ in inflammatory skin lesions in comparison with normal skin. Therefore, we suggest that changes in the activity of these proteins may play role in pathogenesis of inflammatory skin disorders. Furthermore, we suggest that LRP2/megalin, VDR, RORα and RORy may serve as targets in therapy of these diseases.</description><identifier>ISSN: 0906-6705</identifier><identifier>EISSN: 1600-0625</identifier><identifier>DOI: 10.1111/exd.14521</identifier><identifier>PMID: 34995387</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>allergic contact dermatitis ; Contact dermatitis ; Dermatitis ; Humans ; Immunohistochemistry ; Inflammatory diseases ; Keratinocytes ; lichen simplex chronicus ; Low Density Lipoprotein Receptor-Related Protein-2 ; LRP2 protein ; megalin ; Nuclear Receptor Subfamily 1, Group F, Member 1 ; Nuclear Receptor Subfamily 1, Group F, Member 3 ; Nuclear receptors ; Orphan receptors ; Pathogenesis ; Psoriasis ; Receptors, Calcitriol - metabolism ; Retinoic acid ; Retinoic Acid Receptor alpha ; Sarcoidosis ; Skin diseases ; Skin lesions ; Tretinoin ; Vitamin D ; Vitamin D - metabolism ; Vitamin D receptors ; Vitamin D3 ; Vitamin deficiency ; Vitamins</subject><ispartof>Experimental dermatology, 2022-05, Vol.31 (5), p.781-788</ispartof><rights>2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2022 John Wiley & Sons A/S. 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Vitamin D3 deficiency can correlate with the increased incidence, severity and duration of inflammatory skin disorders. The exact mechanism on how vitamin D3 influences inflammatory skin diseases still requires clarification. However, it can be associated with the disturbances in transmembrane glycoprotein—LRP2/megalin, which is implicated in vitamin D3 transport to the cell, and defects in vitamin D‐signalling through the nuclear receptors. Therefore, by using immunohistochemistry, we analysed the expression of LRP2/megalin, VDR, RORα and RORγ in allergic contact dermatitis, lichen simplex chronicus, sarcoidosis and psoriasis in comparison with the normal skin. We observed decreased expression of LRP2/megalin in all inflammatory lesions in comparison with the normal skin. Significant differences were also noticed in VDR, RORα and RORγ levels between inflammatory lesions and normal skin. Our research indicates disturbed expression of LRP2/megalin, VDR, RORα and RORγ in inflammatory skin lesions in comparison with normal skin. Therefore, we suggest that changes in the activity of these proteins may play role in pathogenesis of inflammatory skin disorders. Furthermore, we suggest that LRP2/megalin, VDR, RORα and RORy may serve as targets in therapy of these diseases.</description><subject>allergic contact dermatitis</subject><subject>Contact dermatitis</subject><subject>Dermatitis</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Inflammatory diseases</subject><subject>Keratinocytes</subject><subject>lichen simplex chronicus</subject><subject>Low Density Lipoprotein Receptor-Related Protein-2</subject><subject>LRP2 protein</subject><subject>megalin</subject><subject>Nuclear Receptor Subfamily 1, Group F, Member 1</subject><subject>Nuclear Receptor Subfamily 1, Group F, Member 3</subject><subject>Nuclear receptors</subject><subject>Orphan receptors</subject><subject>Pathogenesis</subject><subject>Psoriasis</subject><subject>Receptors, Calcitriol - metabolism</subject><subject>Retinoic acid</subject><subject>Retinoic Acid Receptor alpha</subject><subject>Sarcoidosis</subject><subject>Skin diseases</subject><subject>Skin lesions</subject><subject>Tretinoin</subject><subject>Vitamin D</subject><subject>Vitamin D - metabolism</subject><subject>Vitamin D receptors</subject><subject>Vitamin D3</subject><subject>Vitamin deficiency</subject><subject>Vitamins</subject><issn>0906-6705</issn><issn>1600-0625</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFqFTEUhoMo9lpd-AIScKOLaZOZJHNnI0hvrULBjYK7kMmctKkzyZjMtL27btz7KtL36EP4JB7vrUUFQ-BAznd-_pOfkKec7XE8-3DZ7XEhS36PLLhirGCqlPfJgjVMFapmcoc8yvmMMV5XtXxIdirRNLJa1gvydeXzNKcWOgqXY4KcfQw0OnruJzP4QFfUhI4mmHyI3lJjfffj6luC3kw4E9N4agK2LYxTTJnefN_wN9ebgjoDnJgedTbX9WYYDIJrmj_jS-czmAz5MXngTJ_hyW3dJR_fHH44eFscvz96d_D6uLBCVLxom2bJ21YK46STbSNqYUXrSiVMy6VramVdLSsBQrquU7gUV87gbG2gtFZUu-TVVnec2wE6C2FKptdj8oNJax2N1393gj_VJ_Fc40eKRnAUeHErkOKXGfKkB58t9L0JEOesS8WXZcXRLKLP_0HP4pwCroeUXHJ0JRqkXm4pm2LOCdydGc70r3A1hqs34SL77E_3d-TvNBHY3wIXvof1_5X04afVVvInNwWz3g</recordid><startdate>202205</startdate><enddate>202205</enddate><creator>Brożyna, Anna A.</creator><creator>Żmijewski, Michał A.</creator><creator>Linowiecka, Kinga</creator><creator>Kim, Tae‐Kang</creator><creator>Slominski, Radomir M.</creator><creator>Slominski, Andrzej T.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3195-9965</orcidid><orcidid>https://orcid.org/0000-0002-2929-1118</orcidid><orcidid>https://orcid.org/0000-0002-7029-2657</orcidid><orcidid>https://orcid.org/0000-0001-8963-3995</orcidid><orcidid>https://orcid.org/0000-0003-2206-3531</orcidid><orcidid>https://orcid.org/0000-0003-1394-4134</orcidid></search><sort><creationdate>202205</creationdate><title>Disturbed expression of vitamin D and retinoic acid‐related orphan receptors α and γ and of megalin in inflammatory skin diseases</title><author>Brożyna, Anna A. ; Żmijewski, Michał A. ; Linowiecka, Kinga ; Kim, Tae‐Kang ; Slominski, Radomir M. ; Slominski, Andrzej T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4431-b9981bb54af5f5b9474c4bf264ab15f976cf7534e45fdd6bed16fac447ae2cc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>allergic contact dermatitis</topic><topic>Contact dermatitis</topic><topic>Dermatitis</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Inflammatory diseases</topic><topic>Keratinocytes</topic><topic>lichen simplex chronicus</topic><topic>Low Density Lipoprotein Receptor-Related Protein-2</topic><topic>LRP2 protein</topic><topic>megalin</topic><topic>Nuclear Receptor Subfamily 1, Group F, Member 1</topic><topic>Nuclear Receptor Subfamily 1, Group F, Member 3</topic><topic>Nuclear receptors</topic><topic>Orphan receptors</topic><topic>Pathogenesis</topic><topic>Psoriasis</topic><topic>Receptors, Calcitriol - metabolism</topic><topic>Retinoic acid</topic><topic>Retinoic Acid Receptor alpha</topic><topic>Sarcoidosis</topic><topic>Skin diseases</topic><topic>Skin lesions</topic><topic>Tretinoin</topic><topic>Vitamin D</topic><topic>Vitamin D - metabolism</topic><topic>Vitamin D receptors</topic><topic>Vitamin D3</topic><topic>Vitamin deficiency</topic><topic>Vitamins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brożyna, Anna A.</creatorcontrib><creatorcontrib>Żmijewski, Michał A.</creatorcontrib><creatorcontrib>Linowiecka, Kinga</creatorcontrib><creatorcontrib>Kim, Tae‐Kang</creatorcontrib><creatorcontrib>Slominski, Radomir M.</creatorcontrib><creatorcontrib>Slominski, Andrzej T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brożyna, Anna A.</au><au>Żmijewski, Michał A.</au><au>Linowiecka, Kinga</au><au>Kim, Tae‐Kang</au><au>Slominski, Radomir M.</au><au>Slominski, Andrzej T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disturbed expression of vitamin D and retinoic acid‐related orphan receptors α and γ and of megalin in inflammatory skin diseases</atitle><jtitle>Experimental dermatology</jtitle><addtitle>Exp Dermatol</addtitle><date>2022-05</date><risdate>2022</risdate><volume>31</volume><issue>5</issue><spage>781</spage><epage>788</epage><pages>781-788</pages><issn>0906-6705</issn><eissn>1600-0625</eissn><abstract>The pathogenesis of inflammatory skin diseases is associated with the abnormal activity of keratinocytes and immune cells infiltrate. Vitamin D3 deficiency can correlate with the increased incidence, severity and duration of inflammatory skin disorders. The exact mechanism on how vitamin D3 influences inflammatory skin diseases still requires clarification. However, it can be associated with the disturbances in transmembrane glycoprotein—LRP2/megalin, which is implicated in vitamin D3 transport to the cell, and defects in vitamin D‐signalling through the nuclear receptors. Therefore, by using immunohistochemistry, we analysed the expression of LRP2/megalin, VDR, RORα and RORγ in allergic contact dermatitis, lichen simplex chronicus, sarcoidosis and psoriasis in comparison with the normal skin. We observed decreased expression of LRP2/megalin in all inflammatory lesions in comparison with the normal skin. Significant differences were also noticed in VDR, RORα and RORγ levels between inflammatory lesions and normal skin. Our research indicates disturbed expression of LRP2/megalin, VDR, RORα and RORγ in inflammatory skin lesions in comparison with normal skin. Therefore, we suggest that changes in the activity of these proteins may play role in pathogenesis of inflammatory skin disorders. Furthermore, we suggest that LRP2/megalin, VDR, RORα and RORy may serve as targets in therapy of these diseases.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34995387</pmid><doi>10.1111/exd.14521</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3195-9965</orcidid><orcidid>https://orcid.org/0000-0002-2929-1118</orcidid><orcidid>https://orcid.org/0000-0002-7029-2657</orcidid><orcidid>https://orcid.org/0000-0001-8963-3995</orcidid><orcidid>https://orcid.org/0000-0003-2206-3531</orcidid><orcidid>https://orcid.org/0000-0003-1394-4134</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Experimental dermatology, 2022-05, Vol.31 (5), p.781-788 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | allergic contact dermatitis Contact dermatitis Dermatitis Humans Immunohistochemistry Inflammatory diseases Keratinocytes lichen simplex chronicus Low Density Lipoprotein Receptor-Related Protein-2 LRP2 protein megalin Nuclear Receptor Subfamily 1, Group F, Member 1 Nuclear Receptor Subfamily 1, Group F, Member 3 Nuclear receptors Orphan receptors Pathogenesis Psoriasis Receptors, Calcitriol - metabolism Retinoic acid Retinoic Acid Receptor alpha Sarcoidosis Skin diseases Skin lesions Tretinoin Vitamin D Vitamin D - metabolism Vitamin D receptors Vitamin D3 Vitamin deficiency Vitamins |
| title | Disturbed expression of vitamin D and retinoic acid‐related orphan receptors α and γ and of megalin in inflammatory skin diseases |
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