Tumor Expression Quantitative Trait Methylation Screening Reveals Distinct CpG Panels for Deconvolving Cancer Immune Signatures

DNA methylation signatures in tumors could serve as reliable biomarkers that are accessible in archival tissues for tracking the epigenetic dynamics shaped by both cancer cells and the tumor microenvironment. However, given the ultrahigh dimensionality and noncollapsible nature of the data, it remai...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2022-05, Vol.82 (9), p.1724-1735
Hauptverfasser:	Yu, Xiaoqing, Cen, Ling, Chen, Y Ann, Markowitz, Joseph, Shaw, Timothy I, Tsai, Kenneth Y, Conejo-Garcia, Jose R, Wang, Xuefeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - genetics CpG Islands - genetics DNA Methylation Early Detection of Cancer Epigenomics Gene Expression Regulation, Neoplastic Humans Melanoma - genetics Melanoma - pathology Phenotype Prognosis Tumor Microenvironment - genetics
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