The diagnostic utility of unenhanced computed tomography of the brain and D-dimer levels in acute cerebral venous sinus thrombosis: A quantitative study
(1) To calculate the sensitivity and specificity of the Hounsfield Unit (HU), the HU to hematocrit (H:H) ratio, and the D-dimer level in the diagnosis of acute CVST. (2) To assess the D-dimer level's linear relationship with the HU and the H:H ratio. A single-center retrospective case-control s...
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| Veröffentlicht in: | Journal of clinical imaging science 2022, Vol.12, p.15-15 |
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| description | (1) To calculate the sensitivity and specificity of the Hounsfield Unit (HU), the HU to hematocrit (H:H) ratio, and the D-dimer level in the diagnosis of acute CVST. (2) To assess the D-dimer level's linear relationship with the HU and the H:H ratio.
A single-center retrospective case-control study was conducted from 2005 to 2020. The inclusion criteria for the thrombosed and control groups were specified. A region of interest (ROI) was plotted on the respective sinuses to calculate the HU. The H:H ratio was calculated by dividing the HU value by the hematocrit value. The receiver operating characteristic curve was used to calculate the sensitivity and specificity of the HU and the H:H ratio at different cutoff values. The Pearson correlation was used to assess the linear relationship between the D-dimer level and the HU and H:H ratio.
There were 19 patients in the thrombosed group and 28 patients in the control group. There were significant differences in the mean HU (71 ± 6.3 vs. 45 ± 4.8,
< 0.001) and the mean H:H ratio (2.11 ± 0.38 vs. 1.46 ± 0.63,
< 0.001). An optimal HU value of 56 yielded 100% sensitivity and specificity. An H:H value of 1.48 yielded a sensitivity of 100% and a specificity of 65%, an H:H ratio of 1.77 demonstrated a sensitivity of 85% and a specificity of 90%, and an H:H ratio of 1.88 yielded a sensitivity of 79% and a specificity of 93%. D-dimer levels had a 95% and 71% sensitivity and specificity, respectively. There was a significant moderately positive linear correlation between the D-dimer level and the HU (r = 0.52,
< 0.001) and the H:H ratio (r = 0.61,
< 0.001).
Unenhanced CT of the brain can be a valuable objective diagnostic tool for acute CVST diagnosis. Hounsfield blood density and its normalized ratio with hematocrit are positively correlated with D-dimer levels, which may indicate active blood coagulation in a cerebral venous sinus. |
| doi_str_mv | 10.25259/JCIS_76_2021 |
| format | Article |
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A single-center retrospective case-control study was conducted from 2005 to 2020. The inclusion criteria for the thrombosed and control groups were specified. A region of interest (ROI) was plotted on the respective sinuses to calculate the HU. The H:H ratio was calculated by dividing the HU value by the hematocrit value. The receiver operating characteristic curve was used to calculate the sensitivity and specificity of the HU and the H:H ratio at different cutoff values. The Pearson correlation was used to assess the linear relationship between the D-dimer level and the HU and H:H ratio.
There were 19 patients in the thrombosed group and 28 patients in the control group. There were significant differences in the mean HU (71 ± 6.3 vs. 45 ± 4.8,
< 0.001) and the mean H:H ratio (2.11 ± 0.38 vs. 1.46 ± 0.63,
< 0.001). An optimal HU value of 56 yielded 100% sensitivity and specificity. An H:H value of 1.48 yielded a sensitivity of 100% and a specificity of 65%, an H:H ratio of 1.77 demonstrated a sensitivity of 85% and a specificity of 90%, and an H:H ratio of 1.88 yielded a sensitivity of 79% and a specificity of 93%. D-dimer levels had a 95% and 71% sensitivity and specificity, respectively. There was a significant moderately positive linear correlation between the D-dimer level and the HU (r = 0.52,
< 0.001) and the H:H ratio (r = 0.61,
< 0.001).
Unenhanced CT of the brain can be a valuable objective diagnostic tool for acute CVST diagnosis. Hounsfield blood density and its normalized ratio with hematocrit are positively correlated with D-dimer levels, which may indicate active blood coagulation in a cerebral venous sinus.</description><identifier>ISSN: 2156-7514</identifier><identifier>EISSN: 2156-5597</identifier><identifier>DOI: 10.25259/JCIS_76_2021</identifier><identifier>PMID: 35510244</identifier><language>eng</language><publisher>United States: Scientific Scholar</publisher><subject>Neuroradiology/Head and Neck Imaging ; Original Research</subject><ispartof>Journal of clinical imaging science, 2022, Vol.12, p.15-15</ispartof><rights>2022 Published by Scientific Scholar on behalf of Journal of Clinical Imaging Science.</rights><rights>2022 Published by Scientific Scholar on behalf of Journal of Clinical Imaging Science 2022 Journal of Clinical Imaging Science</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1553-dcfa2ff6fb97575e66957cb759a1159866690c63e7d8aaef887da85e14c2a1133</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062933/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062933/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35510244$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alharbi, Omar Abdullah</creatorcontrib><creatorcontrib>Alahmadi, Khalid Omar</creatorcontrib><title>The diagnostic utility of unenhanced computed tomography of the brain and D-dimer levels in acute cerebral venous sinus thrombosis: A quantitative study</title><title>Journal of clinical imaging science</title><addtitle>J Clin Imaging Sci</addtitle><description>(1) To calculate the sensitivity and specificity of the Hounsfield Unit (HU), the HU to hematocrit (H:H) ratio, and the D-dimer level in the diagnosis of acute CVST. (2) To assess the D-dimer level's linear relationship with the HU and the H:H ratio.
A single-center retrospective case-control study was conducted from 2005 to 2020. The inclusion criteria for the thrombosed and control groups were specified. A region of interest (ROI) was plotted on the respective sinuses to calculate the HU. The H:H ratio was calculated by dividing the HU value by the hematocrit value. The receiver operating characteristic curve was used to calculate the sensitivity and specificity of the HU and the H:H ratio at different cutoff values. The Pearson correlation was used to assess the linear relationship between the D-dimer level and the HU and H:H ratio.
There were 19 patients in the thrombosed group and 28 patients in the control group. There were significant differences in the mean HU (71 ± 6.3 vs. 45 ± 4.8,
< 0.001) and the mean H:H ratio (2.11 ± 0.38 vs. 1.46 ± 0.63,
< 0.001). An optimal HU value of 56 yielded 100% sensitivity and specificity. An H:H value of 1.48 yielded a sensitivity of 100% and a specificity of 65%, an H:H ratio of 1.77 demonstrated a sensitivity of 85% and a specificity of 90%, and an H:H ratio of 1.88 yielded a sensitivity of 79% and a specificity of 93%. D-dimer levels had a 95% and 71% sensitivity and specificity, respectively. There was a significant moderately positive linear correlation between the D-dimer level and the HU (r = 0.52,
< 0.001) and the H:H ratio (r = 0.61,
< 0.001).
Unenhanced CT of the brain can be a valuable objective diagnostic tool for acute CVST diagnosis. Hounsfield blood density and its normalized ratio with hematocrit are positively correlated with D-dimer levels, which may indicate active blood coagulation in a cerebral venous sinus.</description><subject>Neuroradiology/Head and Neck Imaging</subject><subject>Original Research</subject><issn>2156-7514</issn><issn>2156-5597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpVUUtv1DAQthCIVqVHrshHLqGxk7FjDkjV8mirSj20nC3HnmyMEnsbOyvtP-Hn4sKC6BxmRjPffPMi5C2rP3DgoC5uNtf3WgrNa85ekFPOQFQASr48-hJYe0LOU_pRF2lVK2p4TU4aAFbztj0lPx9GpM6bbYgpe0vX7CefDzQOdA0YRhMsOmrjvFtzcXKc43Yxu_E3IpfafjE-UBMc_Vw5P-NCJ9zjlOhT1JYianHBgproHkNcE00-FJ3HJc59TD59pJf0cTUh-2yy3yNNeXWHN-TVYKaE50d7Rr5__fKwuapu775dby5vK8sAmsrZwfBhEEOvJEhAIRRI20tQhjFQnSiB2ooGpeuMwaHrpDMdIGstL4imOSOf_vDu1n5GZzHkMqveLX42y0FH4_XzTPCj3sa9VrXgqnkieH8kWOLjiinr2SeL02QClnU1F6IuxwalCvTd_73-Nfn7juYXVwuRzw</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Alharbi, Omar Abdullah</creator><creator>Alahmadi, Khalid Omar</creator><general>Scientific Scholar</general><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2022</creationdate><title>The diagnostic utility of unenhanced computed tomography of the brain and D-dimer levels in acute cerebral venous sinus thrombosis: A quantitative study</title><author>Alharbi, Omar Abdullah ; Alahmadi, Khalid Omar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1553-dcfa2ff6fb97575e66957cb759a1159866690c63e7d8aaef887da85e14c2a1133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Neuroradiology/Head and Neck Imaging</topic><topic>Original Research</topic><toplevel>online_resources</toplevel><creatorcontrib>Alharbi, Omar Abdullah</creatorcontrib><creatorcontrib>Alahmadi, Khalid Omar</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical imaging science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alharbi, Omar Abdullah</au><au>Alahmadi, Khalid Omar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The diagnostic utility of unenhanced computed tomography of the brain and D-dimer levels in acute cerebral venous sinus thrombosis: A quantitative study</atitle><jtitle>Journal of clinical imaging science</jtitle><addtitle>J Clin Imaging Sci</addtitle><date>2022</date><risdate>2022</risdate><volume>12</volume><spage>15</spage><epage>15</epage><pages>15-15</pages><issn>2156-7514</issn><eissn>2156-5597</eissn><abstract>(1) To calculate the sensitivity and specificity of the Hounsfield Unit (HU), the HU to hematocrit (H:H) ratio, and the D-dimer level in the diagnosis of acute CVST. (2) To assess the D-dimer level's linear relationship with the HU and the H:H ratio.
A single-center retrospective case-control study was conducted from 2005 to 2020. The inclusion criteria for the thrombosed and control groups were specified. A region of interest (ROI) was plotted on the respective sinuses to calculate the HU. The H:H ratio was calculated by dividing the HU value by the hematocrit value. The receiver operating characteristic curve was used to calculate the sensitivity and specificity of the HU and the H:H ratio at different cutoff values. The Pearson correlation was used to assess the linear relationship between the D-dimer level and the HU and H:H ratio.
There were 19 patients in the thrombosed group and 28 patients in the control group. There were significant differences in the mean HU (71 ± 6.3 vs. 45 ± 4.8,
< 0.001) and the mean H:H ratio (2.11 ± 0.38 vs. 1.46 ± 0.63,
< 0.001). An optimal HU value of 56 yielded 100% sensitivity and specificity. An H:H value of 1.48 yielded a sensitivity of 100% and a specificity of 65%, an H:H ratio of 1.77 demonstrated a sensitivity of 85% and a specificity of 90%, and an H:H ratio of 1.88 yielded a sensitivity of 79% and a specificity of 93%. D-dimer levels had a 95% and 71% sensitivity and specificity, respectively. There was a significant moderately positive linear correlation between the D-dimer level and the HU (r = 0.52,
< 0.001) and the H:H ratio (r = 0.61,
< 0.001).
Unenhanced CT of the brain can be a valuable objective diagnostic tool for acute CVST diagnosis. Hounsfield blood density and its normalized ratio with hematocrit are positively correlated with D-dimer levels, which may indicate active blood coagulation in a cerebral venous sinus.</abstract><cop>United States</cop><pub>Scientific Scholar</pub><pmid>35510244</pmid><doi>10.25259/JCIS_76_2021</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Neuroradiology/Head and Neck Imaging Original Research |
| title | The diagnostic utility of unenhanced computed tomography of the brain and D-dimer levels in acute cerebral venous sinus thrombosis: A quantitative study |
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