Lithium attenuates blood–brain barrier damage and brain edema following intracerebral hemorrhage via an endothelial Wnt/β‐catenin signaling‐dependent mechanism in mice

Background Vasogenic cerebral edema resulting from blood–brain barrier (BBB) damage aggravates the devastating consequences of intracerebral hemorrhage (ICH). Although augmentation of endothelial Wnt/β‐catenin signaling substantially alleviates BBB breakdown in animals, no agents based on this mecha...

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Veröffentlicht in:	CNS neuroscience & therapeutics 2022-06, Vol.28 (6), p.862-872
Hauptverfasser:	Song, Dengpan, Ji, Ya‐Bin, Huang, Xiao‐Wen, Ma, Yin‐Zhong, Fang, Cheng, Qiu, Lin‐Hui, Tan, Xi‐Xi, Chen, Yi‐Man, Wang, Sheng‐Nan, Chang, Junlei, Guo, Fuyou
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies beta Catenin - metabolism Blood-brain barrier Blood-Brain Barrier - metabolism Brain Brain Edema - drug therapy Brain Edema - etiology Brain Edema - metabolism Brain injury Catenin Cerebral Hemorrhage - complications Cerebral Hemorrhage - drug therapy Cerebral Hemorrhage - metabolism Collagen Collagenase Edema Endothelium Extravasation Hematoma Hematoma - metabolism Hemorrhage Immunoglobulin G intracerebral hemorrhage Laboratory animals Lithium Lithium - metabolism Lithium - pharmacology Lithium - therapeutic use Mice Mice, Knockout Proteins Rodents Software Special Issue Statistical analysis tight junction Variance analysis Volumetric analysis Wnt protein Wnt Signaling Pathway - physiology Wnt/β‐catenin signaling
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