Engineering O -glycosylation in modified N -linked oligosaccharide (Man 12 GlcNAc 2 ∼Man 16 GlcNAc 2 ) Pichia pastoris strains

Yeast have been engineered for the production of therapeutic glycoproteins with humanized -linked oligosaccharides. Both - and -linked oligosaccharides engineered yeast have been attractive prospects, since yeast-specific -mannosylated proteins were reported to induce an aberrant immune response and...

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Veröffentlicht in:	RSC advances 2019-03, Vol.9 (15), p.8246-8252
Hauptverfasser:	Li, Siqiang, Sun, Peng, Gong, Xin, Chang, Shaohong, Li, Enzhong, Xu, Yuanhong, Wu, Jun, Liu, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Chemistry Degradation Deletion Disruption Genetic engineering Glycoproteins Immune system In vivo methods and tests Mannose Oligosaccharides Pharmacology Proteins Yeast
Online-Zugang:	Volltext
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