Chemical composition and hepatoprotective effect of essential oil from Myrtus communis L. flowers against CCL4-induced acute hepatotoxicity in rats
Myrtus communis L. (Myrtle) is one of the most important aromatic and medicinal species from the Myrtaceae family. It is traditionally used as antiseptic, disinfectant drug and hypoglycemic agent. The aim of our study was to evaluate the protective effect of Myrtus communis essential oil ( Mc EO) on...
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| creator | Ben Hsouna, Anis Dhibi, Sabah Dhifi, Wissal Mnif, Wissem Ben Nasr, hmed Hfaiedh, Najla |
| description | Myrtus communis
L. (Myrtle) is one of the most important aromatic and medicinal species from the Myrtaceae family. It is traditionally used as antiseptic, disinfectant drug and hypoglycemic agent. The aim of our study was to evaluate the protective effect of
Myrtus communis
essential oil (
Mc
EO) on CCl
4
-induced hepatotoxicity in rat. Thirty two adult Wistar rats were divided into 4 groups of 8 each: (1) a control group; (2) was given a single dose of CCl
4
(1 mL kg
−1
in 1% olive oil. ip) on the 14
th
day (3) were given during 15 days a daily i.p. injection of
Mc
EO at 250 mL kg
−1
b.w (4) a group was pretreated with
Mc
EO and intoxicated with CCl
4
on the 14
th
day. The major components of
Mc
EO are α-pinene (35.20%), 1,8-cineole (17%), linalool (6.17%) and limonene (8.94%) which accounted for 67.31% of the whole oil. The antioxidant activity of
Mc
EO was evaluated using DPPH scavenging ability, β-carotene bleaching inhibition and hydroxyl radical-scavenging activity. Moreover, the effect of
Mc
EO (250 mg kg
−1
body weight BW) administrated for 14 consecutive days was evaluated in wistar rat. Administration of a single dose of CCl
4
caused hepatotoxicity as monitored by an increase in lipid peroxidation (thiobarbituric acid reactive substances) as well in protein carbonyl level but decreased in antioxidant markers in the liver tissue. The
Mc
EO pre-treatment significantly prevented the increased plasma levels of hepatic markers and lipid levels induced by CCl
4
in rats. Furthermore, this fraction improved biochemical and histological parameters as compared to CCl
4
-treated group. Our results suggest that
M. communis
contains promising substances to counteract the CCl
4
intoxication and which may be efficient in the prevention of hepatotoxicity complications.
Myrtus communis
L. (Myrtle) is one of the most important aromatic and medicinal species from the Myrtaceae family. |
| doi_str_mv | 10.1039/c8ra08204a |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9060237</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2661081777</sourcerecordid><originalsourceid>FETCH-LOGICAL-p249t-845f02bc5f6616c96e19b0c341f6cdfc938d6912291e3a1bf8b4fa0893d44633</originalsourceid><addsrcrecordid>eNp9kU1P3DAQQK1KqCDgwh3JVS9cAv5IvPEFqYragrSoF-6W44xZo8RObYeyv4M_XK9YFZUDvsxIfvNmxkbojJJLSri8Mm3UpGWk1p_QUQmiYkTIQ3Sa0iMpRzSUCfoZHfKmoS1p5RF66TYwOaNHbMI0h-SyCx5rP-ANzDqHOYYMJrsnwGBtyXCwGFICn10pCm7ENoYJ321jXtJOMi3eJby-xHYMfyAmrB-08ynjrlvXlfPDYmDA2iwZ9j1yeHbG5S12Hked0wk6sHpMcLqPx-j-x_f77qZa__p5231bVzOrZa7aurGE9aaxQlBhpAAqe2J4Ta0wgzWSt4OQlDFJgWva27avbXkfyYe6Fpwfo-tX7bz0EwymrBT1qOboJh23Kmin_r_xbqMewpOSRBDGV0VwsRfE8HuBlNXkkoFx1B7CkhQrc5GWrlY79Os79DEs0ZftFKOrppE7Y6G-vFIxmX9zvH2qmgdbmPOPGP4X0SikIg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2175596023</pqid></control><display><type>article</type><title>Chemical composition and hepatoprotective effect of essential oil from Myrtus communis L. flowers against CCL4-induced acute hepatotoxicity in rats</title><source>Open Access: PubMed Central</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>EZB Electronic Journals Library</source><creator>Ben Hsouna, Anis ; Dhibi, Sabah ; Dhifi, Wissal ; Mnif, Wissem ; Ben Nasr, hmed ; Hfaiedh, Najla</creator><creatorcontrib>Ben Hsouna, Anis ; Dhibi, Sabah ; Dhifi, Wissal ; Mnif, Wissem ; Ben Nasr, hmed ; Hfaiedh, Najla</creatorcontrib><description>Myrtus communis
L. (Myrtle) is one of the most important aromatic and medicinal species from the Myrtaceae family. It is traditionally used as antiseptic, disinfectant drug and hypoglycemic agent. The aim of our study was to evaluate the protective effect of
Myrtus communis
essential oil (
Mc
EO) on CCl
4
-induced hepatotoxicity in rat. Thirty two adult Wistar rats were divided into 4 groups of 8 each: (1) a control group; (2) was given a single dose of CCl
4
(1 mL kg
−1
in 1% olive oil. ip) on the 14
th
day (3) were given during 15 days a daily i.p. injection of
Mc
EO at 250 mL kg
−1
b.w (4) a group was pretreated with
Mc
EO and intoxicated with CCl
4
on the 14
th
day. The major components of
Mc
EO are α-pinene (35.20%), 1,8-cineole (17%), linalool (6.17%) and limonene (8.94%) which accounted for 67.31% of the whole oil. The antioxidant activity of
Mc
EO was evaluated using DPPH scavenging ability, β-carotene bleaching inhibition and hydroxyl radical-scavenging activity. Moreover, the effect of
Mc
EO (250 mg kg
−1
body weight BW) administrated for 14 consecutive days was evaluated in wistar rat. Administration of a single dose of CCl
4
caused hepatotoxicity as monitored by an increase in lipid peroxidation (thiobarbituric acid reactive substances) as well in protein carbonyl level but decreased in antioxidant markers in the liver tissue. The
Mc
EO pre-treatment significantly prevented the increased plasma levels of hepatic markers and lipid levels induced by CCl
4
in rats. Furthermore, this fraction improved biochemical and histological parameters as compared to CCl
4
-treated group. Our results suggest that
M. communis
contains promising substances to counteract the CCl
4
intoxication and which may be efficient in the prevention of hepatotoxicity complications.
Myrtus communis
L. (Myrtle) is one of the most important aromatic and medicinal species from the Myrtaceae family.</description><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/c8ra08204a</identifier><identifier>PMID: 35518089</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Antioxidants ; Bleaching ; Body weight ; Carbon tetrachloride ; Carbonyls ; Carotene ; Chemical composition ; Chemistry ; Composition effects ; Flowers ; Hydroxyl radicals ; Intoxication ; Lipids ; Liver ; Markers ; Oils & fats ; Olive oil ; Organic chemistry ; Pretreatment ; Proteins ; Scavenging ; Thiobarbituric acid</subject><ispartof>RSC advances, 2019-01, Vol.9 (7), p.3777-3787</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><rights>This journal is © The Royal Society of Chemistry 2019 The Royal Society of Chemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060237/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060237/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27915,27916,53782,53784</link.rule.ids></links><search><creatorcontrib>Ben Hsouna, Anis</creatorcontrib><creatorcontrib>Dhibi, Sabah</creatorcontrib><creatorcontrib>Dhifi, Wissal</creatorcontrib><creatorcontrib>Mnif, Wissem</creatorcontrib><creatorcontrib>Ben Nasr, hmed</creatorcontrib><creatorcontrib>Hfaiedh, Najla</creatorcontrib><title>Chemical composition and hepatoprotective effect of essential oil from Myrtus communis L. flowers against CCL4-induced acute hepatotoxicity in rats</title><title>RSC advances</title><description>Myrtus communis
L. (Myrtle) is one of the most important aromatic and medicinal species from the Myrtaceae family. It is traditionally used as antiseptic, disinfectant drug and hypoglycemic agent. The aim of our study was to evaluate the protective effect of
Myrtus communis
essential oil (
Mc
EO) on CCl
4
-induced hepatotoxicity in rat. Thirty two adult Wistar rats were divided into 4 groups of 8 each: (1) a control group; (2) was given a single dose of CCl
4
(1 mL kg
−1
in 1% olive oil. ip) on the 14
th
day (3) were given during 15 days a daily i.p. injection of
Mc
EO at 250 mL kg
−1
b.w (4) a group was pretreated with
Mc
EO and intoxicated with CCl
4
on the 14
th
day. The major components of
Mc
EO are α-pinene (35.20%), 1,8-cineole (17%), linalool (6.17%) and limonene (8.94%) which accounted for 67.31% of the whole oil. The antioxidant activity of
Mc
EO was evaluated using DPPH scavenging ability, β-carotene bleaching inhibition and hydroxyl radical-scavenging activity. Moreover, the effect of
Mc
EO (250 mg kg
−1
body weight BW) administrated for 14 consecutive days was evaluated in wistar rat. Administration of a single dose of CCl
4
caused hepatotoxicity as monitored by an increase in lipid peroxidation (thiobarbituric acid reactive substances) as well in protein carbonyl level but decreased in antioxidant markers in the liver tissue. The
Mc
EO pre-treatment significantly prevented the increased plasma levels of hepatic markers and lipid levels induced by CCl
4
in rats. Furthermore, this fraction improved biochemical and histological parameters as compared to CCl
4
-treated group. Our results suggest that
M. communis
contains promising substances to counteract the CCl
4
intoxication and which may be efficient in the prevention of hepatotoxicity complications.
Myrtus communis
L. (Myrtle) is one of the most important aromatic and medicinal species from the Myrtaceae family.</description><subject>Antioxidants</subject><subject>Bleaching</subject><subject>Body weight</subject><subject>Carbon tetrachloride</subject><subject>Carbonyls</subject><subject>Carotene</subject><subject>Chemical composition</subject><subject>Chemistry</subject><subject>Composition effects</subject><subject>Flowers</subject><subject>Hydroxyl radicals</subject><subject>Intoxication</subject><subject>Lipids</subject><subject>Liver</subject><subject>Markers</subject><subject>Oils & fats</subject><subject>Olive oil</subject><subject>Organic chemistry</subject><subject>Pretreatment</subject><subject>Proteins</subject><subject>Scavenging</subject><subject>Thiobarbituric acid</subject><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kU1P3DAQQK1KqCDgwh3JVS9cAv5IvPEFqYragrSoF-6W44xZo8RObYeyv4M_XK9YFZUDvsxIfvNmxkbojJJLSri8Mm3UpGWk1p_QUQmiYkTIQ3Sa0iMpRzSUCfoZHfKmoS1p5RF66TYwOaNHbMI0h-SyCx5rP-ANzDqHOYYMJrsnwGBtyXCwGFICn10pCm7ENoYJ321jXtJOMi3eJby-xHYMfyAmrB-08ynjrlvXlfPDYmDA2iwZ9j1yeHbG5S12Hked0wk6sHpMcLqPx-j-x_f77qZa__p5231bVzOrZa7aurGE9aaxQlBhpAAqe2J4Ta0wgzWSt4OQlDFJgWva27avbXkfyYe6Fpwfo-tX7bz0EwymrBT1qOboJh23Kmin_r_xbqMewpOSRBDGV0VwsRfE8HuBlNXkkoFx1B7CkhQrc5GWrlY79Os79DEs0ZftFKOrppE7Y6G-vFIxmX9zvH2qmgdbmPOPGP4X0SikIg</recordid><startdate>20190128</startdate><enddate>20190128</enddate><creator>Ben Hsouna, Anis</creator><creator>Dhibi, Sabah</creator><creator>Dhifi, Wissal</creator><creator>Mnif, Wissem</creator><creator>Ben Nasr, hmed</creator><creator>Hfaiedh, Najla</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190128</creationdate><title>Chemical composition and hepatoprotective effect of essential oil from Myrtus communis L. flowers against CCL4-induced acute hepatotoxicity in rats</title><author>Ben Hsouna, Anis ; Dhibi, Sabah ; Dhifi, Wissal ; Mnif, Wissem ; Ben Nasr, hmed ; Hfaiedh, Najla</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p249t-845f02bc5f6616c96e19b0c341f6cdfc938d6912291e3a1bf8b4fa0893d44633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Antioxidants</topic><topic>Bleaching</topic><topic>Body weight</topic><topic>Carbon tetrachloride</topic><topic>Carbonyls</topic><topic>Carotene</topic><topic>Chemical composition</topic><topic>Chemistry</topic><topic>Composition effects</topic><topic>Flowers</topic><topic>Hydroxyl radicals</topic><topic>Intoxication</topic><topic>Lipids</topic><topic>Liver</topic><topic>Markers</topic><topic>Oils & fats</topic><topic>Olive oil</topic><topic>Organic chemistry</topic><topic>Pretreatment</topic><topic>Proteins</topic><topic>Scavenging</topic><topic>Thiobarbituric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ben Hsouna, Anis</creatorcontrib><creatorcontrib>Dhibi, Sabah</creatorcontrib><creatorcontrib>Dhifi, Wissal</creatorcontrib><creatorcontrib>Mnif, Wissem</creatorcontrib><creatorcontrib>Ben Nasr, hmed</creatorcontrib><creatorcontrib>Hfaiedh, Najla</creatorcontrib><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ben Hsouna, Anis</au><au>Dhibi, Sabah</au><au>Dhifi, Wissal</au><au>Mnif, Wissem</au><au>Ben Nasr, hmed</au><au>Hfaiedh, Najla</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemical composition and hepatoprotective effect of essential oil from Myrtus communis L. flowers against CCL4-induced acute hepatotoxicity in rats</atitle><jtitle>RSC advances</jtitle><date>2019-01-28</date><risdate>2019</risdate><volume>9</volume><issue>7</issue><spage>3777</spage><epage>3787</epage><pages>3777-3787</pages><eissn>2046-2069</eissn><abstract>Myrtus communis
L. (Myrtle) is one of the most important aromatic and medicinal species from the Myrtaceae family. It is traditionally used as antiseptic, disinfectant drug and hypoglycemic agent. The aim of our study was to evaluate the protective effect of
Myrtus communis
essential oil (
Mc
EO) on CCl
4
-induced hepatotoxicity in rat. Thirty two adult Wistar rats were divided into 4 groups of 8 each: (1) a control group; (2) was given a single dose of CCl
4
(1 mL kg
−1
in 1% olive oil. ip) on the 14
th
day (3) were given during 15 days a daily i.p. injection of
Mc
EO at 250 mL kg
−1
b.w (4) a group was pretreated with
Mc
EO and intoxicated with CCl
4
on the 14
th
day. The major components of
Mc
EO are α-pinene (35.20%), 1,8-cineole (17%), linalool (6.17%) and limonene (8.94%) which accounted for 67.31% of the whole oil. The antioxidant activity of
Mc
EO was evaluated using DPPH scavenging ability, β-carotene bleaching inhibition and hydroxyl radical-scavenging activity. Moreover, the effect of
Mc
EO (250 mg kg
−1
body weight BW) administrated for 14 consecutive days was evaluated in wistar rat. Administration of a single dose of CCl
4
caused hepatotoxicity as monitored by an increase in lipid peroxidation (thiobarbituric acid reactive substances) as well in protein carbonyl level but decreased in antioxidant markers in the liver tissue. The
Mc
EO pre-treatment significantly prevented the increased plasma levels of hepatic markers and lipid levels induced by CCl
4
in rats. Furthermore, this fraction improved biochemical and histological parameters as compared to CCl
4
-treated group. Our results suggest that
M. communis
contains promising substances to counteract the CCl
4
intoxication and which may be efficient in the prevention of hepatotoxicity complications.
Myrtus communis
L. (Myrtle) is one of the most important aromatic and medicinal species from the Myrtaceae family.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><pmid>35518089</pmid><doi>10.1039/c8ra08204a</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 2046-2069 |
| ispartof | RSC advances, 2019-01, Vol.9 (7), p.3777-3787 |
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| language | eng |
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| source | Open Access: PubMed Central; DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB Electronic Journals Library |
| subjects | Antioxidants Bleaching Body weight Carbon tetrachloride Carbonyls Carotene Chemical composition Chemistry Composition effects Flowers Hydroxyl radicals Intoxication Lipids Liver Markers Oils & fats Olive oil Organic chemistry Pretreatment Proteins Scavenging Thiobarbituric acid |
| title | Chemical composition and hepatoprotective effect of essential oil from Myrtus communis L. flowers against CCL4-induced acute hepatotoxicity in rats |
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