Pancreatic islet reserve in type 1 diabetes

Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by pancreatic islet β cell loss and dysfunction resulting in insulin deficiency and hyperglycemia. During a presymptomatic phase of established β cell autoimmunity, β cell loss may first be evident through assessment of β cell secre...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2021-07, Vol.1495 (1), p.40-54
Hauptverfasser:	Flatt, Anneliese J. S., Greenbaum, Carla J., Shaw, James A. M., Rickels, Michael R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmune diseases Autoimmunity Beta cells Blood glucose Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - physiopathology Glucagon Glucagon - metabolism Glucose Glucose - metabolism Glucose tolerance Humans Hyperglycemia Hyperglycemia - pathology Immunological tolerance Insulin Insulin - biosynthesis Insulin - metabolism Insulin secretion Insulin Secretion - physiology Insulin-Secreting Cells - immunology Insulin-Secreting Cells - pathology Islet cells Pancreas pancreatic islet Pancreatic islet transplantation Peptides Reserve capacity Secretion Transplantation type 1 diabetes α cell β cell
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