Thermoresponsive 2-hydroxy-3-isopropoxypropyl hydroxyethyl cellulose with tunable LCST for drug delivery
Thermoresponsive polymer 2-hydroxy-3-isopropoxypropyl hydroxyethyl celluloses (HIPECs) were successfully synthesized, characterized, and applied for thermoresponsive drug delivery. The lower critical solution temperature (LCST) of HIPEC could be easily tuned from 21.1 to 56.1 °C as the molar substit...
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| Veröffentlicht in: | RSC advances 2019-01, Vol.9 (4), p.2268-2276 |
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| creator | Tian, Ye Liu, Ying Ju, Benzhi Ren, Xiaozhong Dai, Mingyun |
| description | Thermoresponsive polymer 2-hydroxy-3-isopropoxypropyl hydroxyethyl celluloses (HIPECs) were successfully synthesized, characterized, and applied for thermoresponsive drug delivery. The lower critical solution temperature (LCST) of HIPEC could be easily tuned from 21.1 to 56.1 °C as the molar substitution (MS) increased from 1.21 to 2.88. Dynamic light scattering and transmission electron microscopy experiments revealed that HIPEC can self-assemble into nano-sized aggregates, and their size could be changed by variation in temperature. Additionally, the critical aggregation concentration (CAC) ranged from 0.101 to 0.805 g L
by changing MS of HIPEC.
drug delivery studies indicated that the amphotericin B (AmpB) release rate was much faster at temperatures above LCST; approximately 95% of the drug was released from aggregates in 40 h. MTT assays were conducted to evaluate the cytotoxicity of HIPEC, and the observation of the Hoechst 33342 living cell stain using confocal laser scanning microscopy confirmed the high cell viability as HIPECs were used. |
| doi_str_mv | 10.1039/C8RA09075K |
| format | Article |
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by changing MS of HIPEC.
drug delivery studies indicated that the amphotericin B (AmpB) release rate was much faster at temperatures above LCST; approximately 95% of the drug was released from aggregates in 40 h. MTT assays were conducted to evaluate the cytotoxicity of HIPEC, and the observation of the Hoechst 33342 living cell stain using confocal laser scanning microscopy confirmed the high cell viability as HIPECs were used.</description><identifier>ISSN: 2046-2069</identifier><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/C8RA09075K</identifier><identifier>PMID: 35516125</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Aggregates ; Chemical synthesis ; Chemistry ; Drug delivery systems ; Hydroxyethyl celluloses ; Microscopy ; Photon correlation spectroscopy ; Scanning microscopy ; Toxicity ; Transmission electron microscopy</subject><ispartof>RSC advances, 2019-01, Vol.9 (4), p.2268-2276</ispartof><rights>This journal is © The Royal Society of Chemistry.</rights><rights>Copyright Royal Society of Chemistry 2019</rights><rights>This journal is © The Royal Society of Chemistry 2019 The Royal Society of Chemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-c4df1d41abce8407906433785b99371eb506db83634c9935033315e0535c5ab33</citedby><cites>FETCH-LOGICAL-c406t-c4df1d41abce8407906433785b99371eb506db83634c9935033315e0535c5ab33</cites><orcidid>0000-0002-9750-7777</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059852/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059852/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35516125$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tian, Ye</creatorcontrib><creatorcontrib>Liu, Ying</creatorcontrib><creatorcontrib>Ju, Benzhi</creatorcontrib><creatorcontrib>Ren, Xiaozhong</creatorcontrib><creatorcontrib>Dai, Mingyun</creatorcontrib><title>Thermoresponsive 2-hydroxy-3-isopropoxypropyl hydroxyethyl cellulose with tunable LCST for drug delivery</title><title>RSC advances</title><addtitle>RSC Adv</addtitle><description>Thermoresponsive polymer 2-hydroxy-3-isopropoxypropyl hydroxyethyl celluloses (HIPECs) were successfully synthesized, characterized, and applied for thermoresponsive drug delivery. The lower critical solution temperature (LCST) of HIPEC could be easily tuned from 21.1 to 56.1 °C as the molar substitution (MS) increased from 1.21 to 2.88. Dynamic light scattering and transmission electron microscopy experiments revealed that HIPEC can self-assemble into nano-sized aggregates, and their size could be changed by variation in temperature. Additionally, the critical aggregation concentration (CAC) ranged from 0.101 to 0.805 g L
by changing MS of HIPEC.
drug delivery studies indicated that the amphotericin B (AmpB) release rate was much faster at temperatures above LCST; approximately 95% of the drug was released from aggregates in 40 h. MTT assays were conducted to evaluate the cytotoxicity of HIPEC, and the observation of the Hoechst 33342 living cell stain using confocal laser scanning microscopy confirmed the high cell viability as HIPECs were used.</description><subject>Aggregates</subject><subject>Chemical synthesis</subject><subject>Chemistry</subject><subject>Drug delivery systems</subject><subject>Hydroxyethyl celluloses</subject><subject>Microscopy</subject><subject>Photon correlation spectroscopy</subject><subject>Scanning microscopy</subject><subject>Toxicity</subject><subject>Transmission electron microscopy</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpdkV1LwzAUhoMobszd-AOk4I0I1Xw0aXMjSPELB4LO69CPs7Wja2rSTvvvzdic01zk5OQ8vLyHF6FTgq8IZvI6jl5vscQhfz5AQ4oD4VMs5OHee4DG1i6wO4ITKsgxGjDOiSCUD1ExLcAstQHb6NqWK_CoX_S50V-9z_zS6sboxjXr0lfedgRt4ZoMqqqrtAXvs2wLr-3qJK3Am8RvU2-mjZebbu7lUDlV05-go1lSWRhv6wi9399N40d_8vLwFN9O_CzAonV3PiN5QJI0gyjAocQiYCyMeColCwmkHIs8jZhgQeZ-OGaMEQ6YM57xJGVshG42uk2XLiHPoG5NUqnGlMvE9Eonpfo7qctCzfVKScxlxKkTuNgKGP3RgW3VsrTrVZMadGcVFYLgiNBQOvT8H7rQnandeooSETn_TIaOutxQmdHWGpjtzBCs1hmq3wwdfLZvf4f-JMa-AaRdl-M</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Tian, Ye</creator><creator>Liu, Ying</creator><creator>Ju, Benzhi</creator><creator>Ren, Xiaozhong</creator><creator>Dai, Mingyun</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9750-7777</orcidid></search><sort><creationdate>20190101</creationdate><title>Thermoresponsive 2-hydroxy-3-isopropoxypropyl hydroxyethyl cellulose with tunable LCST for drug delivery</title><author>Tian, Ye ; Liu, Ying ; Ju, Benzhi ; Ren, Xiaozhong ; Dai, Mingyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-c4df1d41abce8407906433785b99371eb506db83634c9935033315e0535c5ab33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aggregates</topic><topic>Chemical synthesis</topic><topic>Chemistry</topic><topic>Drug delivery systems</topic><topic>Hydroxyethyl celluloses</topic><topic>Microscopy</topic><topic>Photon correlation spectroscopy</topic><topic>Scanning microscopy</topic><topic>Toxicity</topic><topic>Transmission electron microscopy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tian, Ye</creatorcontrib><creatorcontrib>Liu, Ying</creatorcontrib><creatorcontrib>Ju, Benzhi</creatorcontrib><creatorcontrib>Ren, Xiaozhong</creatorcontrib><creatorcontrib>Dai, Mingyun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tian, Ye</au><au>Liu, Ying</au><au>Ju, Benzhi</au><au>Ren, Xiaozhong</au><au>Dai, Mingyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thermoresponsive 2-hydroxy-3-isopropoxypropyl hydroxyethyl cellulose with tunable LCST for drug delivery</atitle><jtitle>RSC advances</jtitle><addtitle>RSC Adv</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>9</volume><issue>4</issue><spage>2268</spage><epage>2276</epage><pages>2268-2276</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>Thermoresponsive polymer 2-hydroxy-3-isopropoxypropyl hydroxyethyl celluloses (HIPECs) were successfully synthesized, characterized, and applied for thermoresponsive drug delivery. The lower critical solution temperature (LCST) of HIPEC could be easily tuned from 21.1 to 56.1 °C as the molar substitution (MS) increased from 1.21 to 2.88. Dynamic light scattering and transmission electron microscopy experiments revealed that HIPEC can self-assemble into nano-sized aggregates, and their size could be changed by variation in temperature. Additionally, the critical aggregation concentration (CAC) ranged from 0.101 to 0.805 g L
by changing MS of HIPEC.
drug delivery studies indicated that the amphotericin B (AmpB) release rate was much faster at temperatures above LCST; approximately 95% of the drug was released from aggregates in 40 h. MTT assays were conducted to evaluate the cytotoxicity of HIPEC, and the observation of the Hoechst 33342 living cell stain using confocal laser scanning microscopy confirmed the high cell viability as HIPECs were used.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>35516125</pmid><doi>10.1039/C8RA09075K</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-9750-7777</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Aggregates Chemical synthesis Chemistry Drug delivery systems Hydroxyethyl celluloses Microscopy Photon correlation spectroscopy Scanning microscopy Toxicity Transmission electron microscopy |
| title | Thermoresponsive 2-hydroxy-3-isopropoxypropyl hydroxyethyl cellulose with tunable LCST for drug delivery |
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