Narcolepsy-like symptoms triggered by lemborexant in the context of hyperactive delirium in a patient with bipolar depression: a case report

Lemborexant is a dual orexin antagonist and is considered a safe and effective hypnotic. Dual orexin antagonists induce physiological sleep by blocking orexin receptors. Although the blockade of orexin signaling has triggered narcolepsy-like symptoms in rodents, there is currently no evidence of lem...

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Veröffentlicht in:	Journal of clinical sleep medicine 2022-05, Vol.18 (5), p.1459-1462
Hauptverfasser:	Shibata, Shintaro, Oda, Yasunori, Ohki, Nozomi, Ikemizu, Yuki, Hayatsu, Ryunosuke, Hirose, Yuki, Iyo, Masaomi
Format:	Artikel
Sprache:	eng
Schlagworte:	Bipolar Disorder - complications Bipolar Disorder - drug therapy Case Reports Cataplexy Delirium - chemically induced Female Humans Narcolepsy - drug therapy Orexin Receptor Antagonists - adverse effects Orexins Pyridines Pyrimidines
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