Restless legs syndrome is associated with long-COVID in women
Sleep disturbance is common in long-COVID (LC). Restless legs syndrome (RLS) is characterized by sleep disturbance and has been reported after viral infections. Therefore, we evaluated RLS symptoms cross-sectionally in individuals with LC at both current and pre-coronavirus disease 2019 (pre-COVID-1...
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| Veröffentlicht in: | Journal of clinical sleep medicine 2022-05, Vol.18 (5), p.1413-1418 |
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| creator | Weinstock, Leonard B Brook, Jill B Walters, Arthur S Goris, Ashleigh Afrin, Lawrence B Molderings, Gerhard J |
| description | Sleep disturbance is common in long-COVID (LC). Restless legs syndrome (RLS) is characterized by sleep disturbance and has been reported after viral infections. Therefore, we evaluated RLS symptoms cross-sectionally in individuals with LC at both current and pre-coronavirus disease 2019 (pre-COVID-19) time points.
Adults on LC-focused Facebook pages were recruited for an online assessment of symptoms before COVID-19 infection and during their present LC state in a cross-sectional manner. The LC group documented baseline symptoms retrospectively. Questions were included about the presence/severity of RLS symptoms and assessments of fatigue, quality of life, and sleep apnea. A control group was recruited and included individuals ≥ 18 years of age who never had overt symptoms of COVID-19. Pregnancy was an exclusion criterion for both groups.
There were 136 participants with LC (89.7% females, age 46.9 ± 12.9 years) and 136 controls (65.4% females, age 49.2 ± 15.5). RLS prevalence in females with LC was 5.7% pre-COVID-19 and 14.8% post-COVID-19 (
< .01) vs 6.7% in control females. Severity of RLS was moderate in both groups. Logistic regression predicting post-COVID-19 RLS among females with LC failed to find significant effects of hospitalization, sleep apnea, neuropathic pain severity, or use of antihistamines and antidepressants.
The baseline prevalence of RLS in females with LC was similar to the general population group as well as to patients in epidemiological studies. The prevalence significantly increased in the LC state. Postinfectious immunological mechanisms may be at play in the production for RLS symptoms.
Weinstock LB, Brook JB, Walters AS, Goris A, Afrin LB, Molderings GJ. Restless legs syndrome is associated with long-COVID in women.
. 2022;18(5):1413-1418. |
| doi_str_mv | 10.5664/jcsm.9898 |
| format | Article |
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Adults on LC-focused Facebook pages were recruited for an online assessment of symptoms before COVID-19 infection and during their present LC state in a cross-sectional manner. The LC group documented baseline symptoms retrospectively. Questions were included about the presence/severity of RLS symptoms and assessments of fatigue, quality of life, and sleep apnea. A control group was recruited and included individuals ≥ 18 years of age who never had overt symptoms of COVID-19. Pregnancy was an exclusion criterion for both groups.
There were 136 participants with LC (89.7% females, age 46.9 ± 12.9 years) and 136 controls (65.4% females, age 49.2 ± 15.5). RLS prevalence in females with LC was 5.7% pre-COVID-19 and 14.8% post-COVID-19 (
< .01) vs 6.7% in control females. Severity of RLS was moderate in both groups. Logistic regression predicting post-COVID-19 RLS among females with LC failed to find significant effects of hospitalization, sleep apnea, neuropathic pain severity, or use of antihistamines and antidepressants.
The baseline prevalence of RLS in females with LC was similar to the general population group as well as to patients in epidemiological studies. The prevalence significantly increased in the LC state. Postinfectious immunological mechanisms may be at play in the production for RLS symptoms.
Weinstock LB, Brook JB, Walters AS, Goris A, Afrin LB, Molderings GJ. Restless legs syndrome is associated with long-COVID in women.
. 2022;18(5):1413-1418.</description><identifier>ISSN: 1550-9389</identifier><identifier>ISSN: 1550-9397</identifier><identifier>EISSN: 1550-9397</identifier><identifier>DOI: 10.5664/jcsm.9898</identifier><identifier>PMID: 35484639</identifier><language>eng</language><publisher>United States: American Academy of Sleep Medicine</publisher><subject>Adult ; COVID-19 - complications ; Cross-Sectional Studies ; Female ; Humans ; Middle Aged ; Post-Acute COVID-19 Syndrome ; Pregnancy ; Pregnancy Complications, Infectious ; Quality of Life ; Restless Legs Syndrome - complications ; Restless Legs Syndrome - diagnosis ; Restless Legs Syndrome - epidemiology ; Retrospective Studies ; Scientific Investigations ; Sleep Apnea Syndromes - complications ; Sleep Wake Disorders - complications ; Sleep Wake Disorders - epidemiology</subject><ispartof>Journal of clinical sleep medicine, 2022-05, Vol.18 (5), p.1413-1418</ispartof><rights>2022 American Academy of Sleep Medicine.</rights><rights>2022 American Academy of Sleep Medicine 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-38d9f9e9f20030602bfa000ef929d0cf5cfac4edb9d2e019d52cbad7d6d1b0aa3</citedby><cites>FETCH-LOGICAL-c375t-38d9f9e9f20030602bfa000ef929d0cf5cfac4edb9d2e019d52cbad7d6d1b0aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059584/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059584/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35484639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weinstock, Leonard B</creatorcontrib><creatorcontrib>Brook, Jill B</creatorcontrib><creatorcontrib>Walters, Arthur S</creatorcontrib><creatorcontrib>Goris, Ashleigh</creatorcontrib><creatorcontrib>Afrin, Lawrence B</creatorcontrib><creatorcontrib>Molderings, Gerhard J</creatorcontrib><title>Restless legs syndrome is associated with long-COVID in women</title><title>Journal of clinical sleep medicine</title><addtitle>J Clin Sleep Med</addtitle><description>Sleep disturbance is common in long-COVID (LC). Restless legs syndrome (RLS) is characterized by sleep disturbance and has been reported after viral infections. Therefore, we evaluated RLS symptoms cross-sectionally in individuals with LC at both current and pre-coronavirus disease 2019 (pre-COVID-19) time points.
Adults on LC-focused Facebook pages were recruited for an online assessment of symptoms before COVID-19 infection and during their present LC state in a cross-sectional manner. The LC group documented baseline symptoms retrospectively. Questions were included about the presence/severity of RLS symptoms and assessments of fatigue, quality of life, and sleep apnea. A control group was recruited and included individuals ≥ 18 years of age who never had overt symptoms of COVID-19. Pregnancy was an exclusion criterion for both groups.
There were 136 participants with LC (89.7% females, age 46.9 ± 12.9 years) and 136 controls (65.4% females, age 49.2 ± 15.5). RLS prevalence in females with LC was 5.7% pre-COVID-19 and 14.8% post-COVID-19 (
< .01) vs 6.7% in control females. Severity of RLS was moderate in both groups. Logistic regression predicting post-COVID-19 RLS among females with LC failed to find significant effects of hospitalization, sleep apnea, neuropathic pain severity, or use of antihistamines and antidepressants.
The baseline prevalence of RLS in females with LC was similar to the general population group as well as to patients in epidemiological studies. The prevalence significantly increased in the LC state. Postinfectious immunological mechanisms may be at play in the production for RLS symptoms.
Weinstock LB, Brook JB, Walters AS, Goris A, Afrin LB, Molderings GJ. Restless legs syndrome is associated with long-COVID in women.
. 2022;18(5):1413-1418.</description><subject>Adult</subject><subject>COVID-19 - complications</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Post-Acute COVID-19 Syndrome</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious</subject><subject>Quality of Life</subject><subject>Restless Legs Syndrome - complications</subject><subject>Restless Legs Syndrome - diagnosis</subject><subject>Restless Legs Syndrome - epidemiology</subject><subject>Retrospective Studies</subject><subject>Scientific Investigations</subject><subject>Sleep Apnea Syndromes - complications</subject><subject>Sleep Wake Disorders - complications</subject><subject>Sleep Wake Disorders - epidemiology</subject><issn>1550-9389</issn><issn>1550-9397</issn><issn>1550-9397</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1Lw0AQhhdRbK0e_AOyRz2kTnazSfagIPWrUCiIel02-9FuSbI1m1r6701pLXqagXl4Z-ZB6DKGIUvT5HahQjXkOc-PUD9mDCJOeXZ86HPeQ2chLAASwjJ2inqUJXmSUt5Hd28mtKUJAZdmFnDY1LrxlcEuYBmCV062RuO1a-e49PUsGk0_x4_Y1XjdUfU5OrGyDOZiXwfo4_npffQaTaYv49HDJFI0Y21Ec80tN9wSAAopkMJKADCWE65BWaasVInRBdfEQMw1I6qQOtOpjguQkg7Q_S53uSoqo5Wp20aWYtm4SjYb4aUT_ye1m4uZ_xYcGGd50gVc7wMa_7XqXhaVC8qUpayNXwVBUpYTSrM47dCbHaoaH0Jj7GFNDGKrW2x1i63ujr36e9eB_PVLfwArRn1H</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>Weinstock, Leonard B</creator><creator>Brook, Jill B</creator><creator>Walters, Arthur S</creator><creator>Goris, Ashleigh</creator><creator>Afrin, Lawrence B</creator><creator>Molderings, Gerhard J</creator><general>American Academy of Sleep Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220501</creationdate><title>Restless legs syndrome is associated with long-COVID in women</title><author>Weinstock, Leonard B ; Brook, Jill B ; Walters, Arthur S ; Goris, Ashleigh ; Afrin, Lawrence B ; Molderings, Gerhard J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-38d9f9e9f20030602bfa000ef929d0cf5cfac4edb9d2e019d52cbad7d6d1b0aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>COVID-19 - complications</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Post-Acute COVID-19 Syndrome</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious</topic><topic>Quality of Life</topic><topic>Restless Legs Syndrome - complications</topic><topic>Restless Legs Syndrome - diagnosis</topic><topic>Restless Legs Syndrome - epidemiology</topic><topic>Retrospective Studies</topic><topic>Scientific Investigations</topic><topic>Sleep Apnea Syndromes - complications</topic><topic>Sleep Wake Disorders - complications</topic><topic>Sleep Wake Disorders - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weinstock, Leonard B</creatorcontrib><creatorcontrib>Brook, Jill B</creatorcontrib><creatorcontrib>Walters, Arthur S</creatorcontrib><creatorcontrib>Goris, Ashleigh</creatorcontrib><creatorcontrib>Afrin, Lawrence B</creatorcontrib><creatorcontrib>Molderings, Gerhard J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical sleep medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weinstock, Leonard B</au><au>Brook, Jill B</au><au>Walters, Arthur S</au><au>Goris, Ashleigh</au><au>Afrin, Lawrence B</au><au>Molderings, Gerhard J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Restless legs syndrome is associated with long-COVID in women</atitle><jtitle>Journal of clinical sleep medicine</jtitle><addtitle>J Clin Sleep Med</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>18</volume><issue>5</issue><spage>1413</spage><epage>1418</epage><pages>1413-1418</pages><issn>1550-9389</issn><issn>1550-9397</issn><eissn>1550-9397</eissn><abstract>Sleep disturbance is common in long-COVID (LC). Restless legs syndrome (RLS) is characterized by sleep disturbance and has been reported after viral infections. Therefore, we evaluated RLS symptoms cross-sectionally in individuals with LC at both current and pre-coronavirus disease 2019 (pre-COVID-19) time points.
Adults on LC-focused Facebook pages were recruited for an online assessment of symptoms before COVID-19 infection and during their present LC state in a cross-sectional manner. The LC group documented baseline symptoms retrospectively. Questions were included about the presence/severity of RLS symptoms and assessments of fatigue, quality of life, and sleep apnea. A control group was recruited and included individuals ≥ 18 years of age who never had overt symptoms of COVID-19. Pregnancy was an exclusion criterion for both groups.
There were 136 participants with LC (89.7% females, age 46.9 ± 12.9 years) and 136 controls (65.4% females, age 49.2 ± 15.5). RLS prevalence in females with LC was 5.7% pre-COVID-19 and 14.8% post-COVID-19 (
< .01) vs 6.7% in control females. Severity of RLS was moderate in both groups. Logistic regression predicting post-COVID-19 RLS among females with LC failed to find significant effects of hospitalization, sleep apnea, neuropathic pain severity, or use of antihistamines and antidepressants.
The baseline prevalence of RLS in females with LC was similar to the general population group as well as to patients in epidemiological studies. The prevalence significantly increased in the LC state. Postinfectious immunological mechanisms may be at play in the production for RLS symptoms.
Weinstock LB, Brook JB, Walters AS, Goris A, Afrin LB, Molderings GJ. Restless legs syndrome is associated with long-COVID in women.
. 2022;18(5):1413-1418.</abstract><cop>United States</cop><pub>American Academy of Sleep Medicine</pub><pmid>35484639</pmid><doi>10.5664/jcsm.9898</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 1550-9389 1550-9397 1550-9397 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult COVID-19 - complications Cross-Sectional Studies Female Humans Middle Aged Post-Acute COVID-19 Syndrome Pregnancy Pregnancy Complications, Infectious Quality of Life Restless Legs Syndrome - complications Restless Legs Syndrome - diagnosis Restless Legs Syndrome - epidemiology Retrospective Studies Scientific Investigations Sleep Apnea Syndromes - complications Sleep Wake Disorders - complications Sleep Wake Disorders - epidemiology |
| title | Restless legs syndrome is associated with long-COVID in women |
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