Inhibition of fumarate reductase in Leishmania major and L. donovani by chalcones

Our previous studies have shown that chalcones exhibit potent antileishmanial and antimalarial activities in vitro and in vivo. Preliminary studies showed that these compounds destroyed the ultrastructure of Leishmania parasite mitochondria and inhibited the respiration and the activity of mitochond...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2001-07, Vol.45 (7), p.2023-2029
Hauptverfasser:	MING CHEN, LIN ZHAI, CHRISTENSEN, Søren Brøgger, THEANDER, Thor G, KHARAZMI, Arsalan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Antiprotozoal Agents - pharmacology Biological and medical sciences chalcone Chalcone - analogs & derivatives Chalcone - pharmacology Chalcones Electron Transport - drug effects Enzyme Inhibitors - pharmacology Leishmania donovani Leishmania donovani - drug effects Leishmania donovani - enzymology Leishmania major Leishmania major - drug effects Leishmania major - enzymology Mechanisms of Action: Physiological Effects Medical sciences Mitochondria - drug effects Mitochondria - enzymology NADH Dehydrogenase - metabolism Permeability - drug effects Pharmacology. Drug treatments Phenylacetates - pharmacology Succinate Cytochrome c Oxidoreductase - metabolism Succinate Dehydrogenase - antagonists & inhibitors Succinate Dehydrogenase - drug effects Succinate Dehydrogenase - metabolism
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